CRCGN012_HEPG2_24H:L05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description l-ascorbic acid 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN012_HEPG2_24H:L05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 5.78102
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.89697
PRR15L proline rich 15-like 4.79515
BLMH bleomycin hydrolase 4.61839
RPP38 ribonuclease P/MRP 38kDa subunit 4.47943
MYLK myosin light chain kinase 4.44568
ATP11B ATPase, class VI, type 11B 4.39159
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.33759
DYNLT3 dynein, light chain, Tctex-type 3 4.18564
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.15764
RPL39L ribosomal protein L39-like 4.0579
E2F2 E2F transcription factor 2 4.05438
CXCR4 chemokine (C-X-C motif) receptor 4 3.69777
CSK c-src tyrosine kinase 3.66638
VAV3 vav 3 guanine nucleotide exchange factor 3.43672
GPATCH8 G patch domain containing 8 3.39676
CCL2 chemokine (C-C motif) ligand 2 3.3286
GSTZ1 glutathione S-transferase zeta 1 3.28804
KDM5A lysine (K)-specific demethylase 5A 3.07803
TIAM1 T-cell lymphoma invasion and metastasis 1 2.8751
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.80777
ABHD6 abhydrolase domain containing 6 2.67362
RXYLT1 ribitol xylosyltransferase 1 2.67211
CARMIL1 capping protein regulator and myosin 1 linker 1 2.51265
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.29533
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.10422
GPER1 G protein-coupled estrogen receptor 1 2.09923
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.09176
KATNIP katanin interacting protein 2.02279

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -4.52517
MRPS2 mitochondrial ribosomal protein S2 -4.41158
ADI1 acireductone dioxygenase 1 -4.10363
CHMP4B charged multivesicular body protein 4B -3.8968
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.81505
PTPRK protein tyrosine phosphatase, receptor type, K -3.59296
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.28845
CCNB2 cyclin B2 -2.95531
CTSD cathepsin D -2.62498
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.29054
GDF15 growth differentiation factor 15 -2.22574
HMG20B high mobility group 20B -2.19865
RFC2 replication factor C (activator 1) 2, 40kDa -2.09853