CRCGN012_HEPG2_24H:L06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description l-ascorbic acid 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

89 genes differentially expressed following the CRCGN012_HEPG2_24H:L06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRR15L proline rich 15-like 6.14815
LCN2 lipocalin 2 5.06268
TIMP2 TIMP metallopeptidase inhibitor 2 5.01751
CHMP6 charged multivesicular body protein 6 4.9259
CSK c-src tyrosine kinase 4.74661
GPER1 G protein-coupled estrogen receptor 1 4.52722
STK10 serine/threonine kinase 10 4.42533
NOTCH1 notch 1 4.00855
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.84779
ZNF589 zinc finger protein 589 3.59214
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.45497
PTK2 protein tyrosine kinase 2 3.41103
PMM2 phosphomannomutase 2 3.40766
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.25621
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.09265
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.01736
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.00154
TESK1 testis-specific kinase 1 2.97033
CCL2 chemokine (C-C motif) ligand 2 2.93559
CYCS cytochrome c, somatic 2.79518
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.79382
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.7413
JRKL JRK-like 2.6355
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.59651
ADGRG1 adhesion G protein-coupled receptor G1 2.55138
GPATCH8 G patch domain containing 8 2.47517
HYOU1 hypoxia up-regulated 1 2.4501
CCNF cyclin F 2.30058
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase 2.24793
NOSIP nitric oxide synthase interacting protein 2.24515
CTSL cathepsin L 2.18717
CBR4 carbonyl reductase 4 2.128
PLSCR1 phospholipid scramblase 1 2.09204
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.07834
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 2.06751
ZNHIT6 zinc finger, HIT-type containing 6 2.04343
KIF18B kinesin family member 18B 2.04002
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 2.01509
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.01432
MSH2 mutS homolog 2 2.00542
HEBP1 heme binding protein 1 2.00405

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -5.91263
MAP7 microtubule-associated protein 7 -5.59717
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.5343
HSPB1 heat shock 27kDa protein 1 -5.17796
DSG2 desmoglein 2 -4.70413
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.63539
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.62577
HLA-DMA major histocompatibility complex, class II, DM alpha -4.50967
ISOC1 isochorismatase domain containing 1 -4.50416
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.00081
PCNA proliferating cell nuclear antigen -3.89437
GNAS GNAS complex locus -3.77207
CCDC86 coiled-coil domain containing 86 -3.74358
WASHC4 WASH complex subunit 4 -3.65386
EIF5 eukaryotic translation initiation factor 5 -3.56568
GDF15 growth differentiation factor 15 -3.45115
EGF epidermal growth factor -3.41451
OXA1L oxidase (cytochrome c) assembly 1-like -3.28719
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.17981
HEATR1 HEAT repeat containing 1 -3.16361
HMG20B high mobility group 20B -3.08395
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.07609
TM9SF3 transmembrane 9 superfamily member 3 -2.78561
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.74217
TOMM70 translocase of outer mitochondrial membrane 70 -2.71627
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.50775
SPAG4 sperm associated antigen 4 -2.50661
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.37086
ITGB1BP1 integrin beta 1 binding protein 1 -2.31429
GLOD4 glyoxalase domain containing 4 -2.25153
RWDD1 RWD domain containing 1 -2.24677
SSBP2 single-stranded DNA binding protein 2 -2.24193
SPX spexin hormone -2.20025
FBXL12 F-box and leucine-rich repeat protein 12 -2.17954
NPY neuropeptide Y -2.1739
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.13714
RRAGC Ras-related GTP binding C -2.12994
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 -2.09506
VPREB1 pre-B lymphocyte 1 -2.06545
FAM13A family with sequence similarity 13, member A -2.06221
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.05138
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.03802
TESMIN testis expressed metallothionein like protein -2.03073
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) -2.01829
RPS25 ribosomal protein S25 -2.01258
PACS1 phosphofurin acidic cluster sorting protein 1 -2.00819
VAT1 vesicle amine transport 1 -2.00633
MTUS2 microtubule associated tumor suppressor candidate 2 -2.00114