CRCGN012_HEPG2_24H:L07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tryptophan 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN012_HEPG2_24H:L07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 4.10441
PHKG2 phosphorylase kinase, gamma 2 (testis) 3.95249
STAP2 signal transducing adaptor family member 2 3.87383
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.71183
SQOR sulfide quinone oxidoreductase 3.70781
LCN2 lipocalin 2 3.63002
CIAO3 cytosolic iron-sulfur assembly component 3 3.54274
WDTC1 WD and tetratricopeptide repeats 1 3.51531
VAT1 vesicle amine transport 1 3.47298
E2F2 E2F transcription factor 2 3.27408
ADGRE5 adhesion G protein-coupled receptor E5 3.23521
ATP11B ATPase, class VI, type 11B 3.19982
STIMATE STIM activating enhancer 3.18215
KLHL21 kelch-like family member 21 3.15385
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.95874
CCDC85B coiled-coil domain containing 85B 2.9429
SOCS2 suppressor of cytokine signaling 2 2.87307
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.86907
PRR15L proline rich 15-like 2.79793
EPHB2 EPH receptor B2 2.76988
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.74898
MVP major vault protein 2.73946
AXIN1 axin 1 2.66109
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.64573
TXNRD1 thioredoxin reductase 1 2.63878
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.62963
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.60763
CDX1 caudal type homeobox 1 2.37797
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.34655
CCL24 chemokine (C-C motif) ligand 24 2.33861
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.31369
RNF186 ring finger protein 186 2.18525
NOX1 NADPH oxidase 1 2.17532
MUC4 mucin 4, cell surface associated 2.153
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.12867
ABHD6 abhydrolase domain containing 6 2.11721
DERA deoxyribose-phosphate aldolase (putative) 2.02987
KDM5A lysine (K)-specific demethylase 5A 2.02357

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -6.51849
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.94416
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.5967
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -4.02746
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.92958
ITGB1BP1 integrin beta 1 binding protein 1 -3.62234
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.34512
DNM1L dynamin 1-like -3.30724
CDC20 cell division cycle 20 -3.1716
USP6NL USP6 N-terminal like -3.09005
SLC35F2 solute carrier family 35, member F2 -3.07323
ADI1 acireductone dioxygenase 1 -3.03427
CCNB2 cyclin B2 -2.89072
LOC124907782 dual specificity protein phosphatase 22 -2.88564
GNAS GNAS complex locus -2.88228
TCEAL4 transcription elongation factor A (SII)-like 4 -2.73457
PSRC1 proline/serine-rich coiled-coil 1 -2.73008
ZNF586 zinc finger protein 586 -2.64303
UGDH UDP-glucose 6-dehydrogenase -2.55536
PCNA proliferating cell nuclear antigen -2.32726
RNF167 ring finger protein 167 -2.07468
ANKRD10 ankyrin repeat domain 10 -2.05434
EIF5 eukaryotic translation initiation factor 5 -2.04373
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.02887
YME1L1 YME1-like 1 ATPase -2.00504