CRCGN012_HEPG2_24H:L10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tryptophan 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

57 genes differentially expressed following the CRCGN012_HEPG2_24H:L10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PNKP polynucleotide kinase 3'-phosphatase 9.04067
E2F2 E2F transcription factor 2 5.79174
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.66365
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.65248
PEX11A peroxisomal biogenesis factor 11 alpha 4.57372
CHMP6 charged multivesicular body protein 6 4.55312
UBQLN2 ubiquilin 2 4.19707
LYN LYN proto-oncogene, Src family tyrosine kinase 4.18167
SMIM40 small integral membrane protein 40 4.14835
CBR3 carbonyl reductase 3 4.05432
HOXA10 homeobox A10 4.02589
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 3.97123
SIRT3 sirtuin 3 3.80224
CGRRF1 cell growth regulator with ring finger domain 1 3.39228
PTOV1 prostate tumor overexpressed 1 3.08178
SATB1 SATB homeobox 1 3.00882
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.93208
EVL Enah/Vasp-like 2.64937
RBBP9 retinoblastoma binding protein 9 2.60526
DEAF1 DEAF1 transcription factor 2.5839
CARMIL1 capping protein regulator and myosin 1 linker 1 2.4911
JADE2 jade family PHD finger 2 2.48784
TTLL1 tubulin tyrosine ligase-like family member 1 2.32224
PMM2 phosphomannomutase 2 2.32054
CCNA1 cyclin A1 2.29248
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.23111
PCNA proliferating cell nuclear antigen 2.18148
CENPU centromere protein U 2.14189
MOCS3 molybdenum cofactor synthesis 3 2.09691
AGGF1 angiogenic factor with G patch and FHA domains 1 2.09129
MRPL23 mitochondrial ribosomal protein L23 2.09034
CTSB cathepsin B 2.08789
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 2.08752
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2.07002
DNAAF2 dynein, axonemal, assembly factor 2 2.06155
MPV17L-BMERB1 MPV17L-BMERB1 readthrough 2.00905

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -8.83
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.55055
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.94067
GOLT1B golgi transport 1B -4.68883
ZNF586 zinc finger protein 586 -4.62195
ZDHHC6 zinc finger, DHHC-type containing 6 -4.54307
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.47456
KDM3A lysine (K)-specific demethylase 3A -4.26963
CDC20 cell division cycle 20 -4.18975
VDAC1 voltage-dependent anion channel 1 -3.09297
FNBP4 formin binding protein 4 -3.03747
FGFR4 fibroblast growth factor receptor 4 -3.03039
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.81149
PCDH17 protocadherin 17 -2.27956
CTNND1 catenin (cadherin-associated protein), delta 1 -2.25152
MXI1 MAX interactor 1, dimerization protein -2.23656
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 -2.15159
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.0741
SAP25 Sin3A-associated protein, 25kDa -2.04315
TDO2 tryptophan 2,3-dioxygenase -2.03244
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.02746