CRCGN012_HEPG2_24H:L13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description safrole 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

627 genes differentially expressed following the CRCGN012_HEPG2_24H:L13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NR1H2 nuclear receptor subfamily 1, group H, member 2 10.0
BACE2 beta-site APP-cleaving enzyme 2 10.0
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 10.0
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 10.0
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 10.0
CSK c-src tyrosine kinase 9.3172
HOXA10 homeobox A10 7.67138
CBR1 carbonyl reductase 1 7.62085
OXCT1 3-oxoacid CoA transferase 1 6.84175
KIFBP kinesin family binding protein 6.8304
CCDC85B coiled-coil domain containing 85B 6.6249
GARRE1 granule associated Rac and RHOG effector 1 5.677
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.33725
STAP2 signal transducing adaptor family member 2 5.25105
PRAF2 PRA1 domain family, member 2 5.23345
KCNK1 potassium channel, two pore domain subfamily K, member 1 5.05105
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 5.01475
ANO1 anoctamin 1, calcium activated chloride channel 5.0
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.97135
SYNGR3 synaptogyrin 3 4.9518
MMP2 matrix metallopeptidase 2 4.83935
GSTZ1 glutathione S-transferase zeta 1 4.80945
E2F2 E2F transcription factor 2 4.7707
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.7467
TBC1D10C TBC1 domain family, member 10C 4.5274
BMX BMX non-receptor tyrosine kinase 4.5153
PRKCH protein kinase C, eta 4.48892
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 4.46805
DUSP4 dual specificity phosphatase 4 4.46222
ATP11B ATPase, class VI, type 11B 4.38095
MUC1 mucin 1, cell surface associated 4.3615
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 4.31313
KAT6A K(lysine) acetyltransferase 6A 4.19802
HSPA2 heat shock 70kDa protein 2 4.1334
TGFB3 transforming growth factor, beta 3 4.11335
LCN2 lipocalin 2 4.1108
MOK MOK protein kinase 4.09765
PPIE peptidylprolyl isomerase E (cyclophilin E) 4.07895
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 4.0738
MAP7 microtubule-associated protein 7 4.0335
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 4.0127
DENND2D DENN/MADD domain containing 2D 3.97775
PRKX protein kinase, X-linked 3.92055
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 3.90538
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 3.79402
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.77675
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.68595
SCYL2 SCY1-like 2 (S. cerevisiae) 3.6337
CCL2 chemokine (C-C motif) ligand 2 3.6107
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 3.50675
ESRP1 epithelial splicing regulatory protein 1 3.4926
MBOAT7 membrane bound O-acyltransferase domain containing 7 3.4666
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.4449
JADE2 jade family PHD finger 2 3.35385
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.30595
IDE insulin-degrading enzyme 3.28872
EXPH5 exophilin 5 3.27872
TWSG1 twisted gastrulation BMP signaling modulator 1 3.27785
KLHL9 kelch-like family member 9 3.2221
GMCL1 germ cell-less, spermatogenesis associated 1 3.20385
CA2 carbonic anhydrase II 3.17155
TNIP1 TNFAIP3 interacting protein 1 3.1254
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.11835
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 3.06035
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 3.03488
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 3.034
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.02688
STX3 syntaxin 3 3.02252
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 3.01869
CHN1 chimerin 1 3.00495
SCN1B sodium channel, voltage gated, type I beta subunit 2.97055
DRC11 dynein regulatory complex subunit 11 2.96265
SNX16 sorting nexin 16 2.93965
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 2.8848
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 2.86675
DCTN5 dynactin 5 (p25) 2.86293
TNFAIP8L2-SCNM1 TNFAIP8L2-SCNM1 readthrough 2.83575
TIAM1 T-cell lymphoma invasion and metastasis 1 2.818
KIF5A kinesin family member 5A 2.81115
APOLD1 apolipoprotein L domain containing 1 2.79545
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.7879
SHB Src homology 2 domain containing adaptor protein B 2.78715
RBM42 RNA binding motif protein 42 2.77355
E2F5 E2F transcription factor 5, p130-binding 2.77185
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 2.76595
FZD10 frizzled class receptor 10 2.75285
THNSL2 threonine synthase-like 2 (S. cerevisiae) 2.74365
GDE1 glycerophosphodiester phosphodiesterase 1 2.7423
UFD1 ubiquitin recognition factor in ER associated degradation 1 2.713
CEP70 centrosomal protein 70kDa 2.7075
GPR143 G protein-coupled receptor 143 2.6934
SPINT1 serine peptidase inhibitor, Kunitz type 1 2.6829
CYCS cytochrome c, somatic 2.6677
LOC122526780 uncharacterized LOC122526780 2.6676
ZBTB11 zinc finger and BTB domain containing 11 2.6464
PNPLA3 patatin-like phospholipase domain containing 3 2.64605
STXBP2 syntaxin binding protein 2 2.64575
SOX17 SRY (sex determining region Y)-box 17 2.64305
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.63632
SMAGP small cell adhesion glycoprotein 2.63515
STX17 syntaxin 17 2.62755
UBE2M ubiquitin-conjugating enzyme E2M 2.6229
SMIM41 small integral membrane protein 41 2.6188
HOXA11 homeobox A11 2.60715
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.60485
WFDC2 WAP four-disulfide core domain 2 2.6036
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.59835
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.59022
ELOVL4 ELOVL fatty acid elongase 4 2.58135
ZNF197 zinc finger protein 197 2.5804
CRTAP cartilage associated protein 2.5782
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 2.5751
EGLN1 egl-9 family hypoxia-inducible factor 1 2.56165
FRAS1 Fraser extracellular matrix complex subunit 1 2.55415
SPINK5 serine peptidase inhibitor, Kazal type 5 2.55245
SCAND1 SCAN domain containing 1 2.5464
CYTH2 cytohesin 2 2.5416
SCMH1 sex comb on midleg homolog 1 (Drosophila) 2.54115
ZNF324 zinc finger protein 324 2.537
FOSL2 FOS-like antigen 2 2.5319
IL24 interleukin 24 2.52635
LORICRIN loricrin cornified envelope precursor protein 2.5177
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 2.51648
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 2.513
AAMDC adipogenesis associated, Mth938 domain containing 2.51055
TRIM28 tripartite motif containing 28 2.4997
LOC128125814 uncharacterized LOC128125814 2.4978
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.49575
ZNF180 zinc finger protein 180 2.49135
PRR5L proline rich 5 like 2.4854
GRB10 growth factor receptor-bound protein 10 2.47502
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.47055
PRKD2 protein kinase D2 2.46673
OCRL oculocerebrorenal syndrome of Lowe 2.4636
EHF ets homologous factor 2.45875
VWF von Willebrand factor 2.4504
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 2.4453
FOXRED2 FAD-dependent oxidoreductase domain containing 2 2.4404
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 2.43165
IL20RA interleukin 20 receptor, alpha 2.43145
MLANA melan-A 2.4294
ZNF74 zinc finger protein 74 2.41985
ATP2A3 ATPase, Ca++ transporting, ubiquitous 2.4176
BTG2 BTG family, member 2 2.41145
ANO10 anoctamin 10 2.41
PLXDC1 plexin domain containing 1 2.40705
EVL Enah/Vasp-like 2.40625
ULK1 unc-51 like autophagy activating kinase 1 2.40555
MED9 mediator complex subunit 9 2.40185
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.4009
SLFN12 schlafen family member 12 2.40005
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.39905
TSPYL5 TSPY-like 5 2.39795
ZNF227 zinc finger protein 227 2.3968
STX5 syntaxin 5 2.3946
EMCN endomucin 2.39445
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.38857
GRWD1 glutamate-rich WD repeat containing 1 2.3852
TPPP tubulin polymerization promoting protein 2.38295
UNC13D unc-13 homolog D (C. elegans) 2.37705
MEF2A myocyte enhancer factor 2A 2.37122
LZTFL1 leucine zipper transcription factor-like 1 2.3665
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.35878
EDAR ectodysplasin A receptor 2.35815
UBE2S ubiquitin-conjugating enzyme E2S 2.34005
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 2.33965
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 2.3375
NOP2 NOP2 nucleolar protein 2.332
LTBP1 latent transforming growth factor beta binding protein 1 2.33122
LSM1 LSM1, U6 small nuclear RNA associated 2.323
IL1R1 interleukin 1 receptor, type I 2.32258
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 2.32228
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 2.32
RLN2 relaxin 2 2.3186
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.31
CDC50B cell division cycle 50 P4-ATPase accessory subunit B 2.30925
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 2.30285
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 2.2999
CYTH3 cytohesin 3 2.2915
RAB4A RAB4A, member RAS oncogene family 2.28958
WASF3 WAS protein family, member 3 2.28795
FLG filaggrin 2.2868
DZIP1 DAZ interacting zinc finger protein 1 2.28585
GMPR guanosine monophosphate reductase 2.28495
SYF2 SYF2 pre-mRNA-splicing factor 2.28305
SYNC syncoilin, intermediate filament protein 2.28145
CAPN3 calpain 3, (p94) 2.2775
RAB36 RAB36, member RAS oncogene family 2.27495
GAB2 GRB2-associated binding protein 2 2.27465
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 2.27402
DPY19L4 dpy-19-like 4 (C. elegans) 2.2739
NDNF neuron-derived neurotrophic factor 2.2675
NRIP3 nuclear receptor interacting protein 3 2.26455
SYT1 synaptotagmin I 2.2622
ZNF394 zinc finger protein 394 2.25825
PADI2 peptidyl arginine deiminase, type II 2.2531
TYRP1 tyrosinase-related protein 1 2.25075
EPHX3 epoxide hydrolase 3 2.25025
MPZL2 myelin protein zero-like 2 2.246
SKAP2 src kinase associated phosphoprotein 2 2.24568
PDGFRB platelet-derived growth factor receptor, beta polypeptide 2.2418
RNF216 ring finger protein 216 2.23723
ACSM3 acyl-CoA synthetase medium-chain family member 3 2.2358
CRYM crystallin, mu 2.23445
PLA2G12A phospholipase A2, group XIIA 2.23375
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.2326
DNM1L dynamin 1-like 2.2228
ACP3 acid phosphatase 3 2.2219
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.21615
PPP1R15A protein phosphatase 1, regulatory subunit 15A 2.2132
LRRC31 leucine rich repeat containing 31 2.2116
EXOC5 exocyst complex component 5 2.2114
CPZ carboxypeptidase Z 2.2044
SNX13 sorting nexin 13 2.20248
EPHB2 EPH receptor B2 2.20214
TUFM Tu translation elongation factor, mitochondrial 2.20145
CABIN1 calcineurin binding protein 1 2.19942
TSPYL1 TSPY-like 1 2.19795
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.19725
MGAM maltase-glucoamylase 2.19535
CXCR2 chemokine (C-X-C motif) receptor 2 2.1925
GPATCH3 G patch domain containing 3 2.1903
PRODH proline dehydrogenase (oxidase) 1 2.187
TPM3 tropomyosin 3 2.1756
PHC2 polyhomeotic homolog 2 (Drosophila) 2.1742
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.17095
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.1689
TBXA2R thromboxane A2 receptor 2.16409
UNC93B1 unc-93 homolog B1 (C. elegans) 2.16345
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 2.16198
ZNF165 zinc finger protein 165 2.1586
CLN3 ceroid-lipofuscinosis, neuronal 3 2.1581
POC1B-GALNT4 POC1B-GALNT4 readthrough 2.15735
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 2.15615
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.15213
BDNF brain-derived neurotrophic factor 2.14975
ST18 suppression of tumorigenicity 18, zinc finger 2.14905
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.14695
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.1422
SLCO4C1 solute carrier organic anion transporter family, member 4C1 2.14165
MCOLN3 mucolipin 3 2.1413
MRM2 mitochondrial rRNA methyltransferase 2 2.13935
GDF7 growth differentiation factor 7 2.1341
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 2.13325
ADAM21 ADAM metallopeptidase domain 21 2.12315
HEBP1 heme binding protein 1 2.12205
ACTN3 actinin, alpha 3 (gene/pseudogene) 2.11965
OSR2 odd-skipped related transciption factor 2 2.11025
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.11005
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 2.11
IPO8 importin 8 2.1076
PCDHB16 protocadherin beta 16 2.1065
TET3 tet methylcytosine dioxygenase 3 2.09985
SPAG1 sperm associated antigen 1 2.0957
USP18 ubiquitin specific peptidase 18 2.0954
FFAR2 free fatty acid receptor 2 2.09385
PSME4 proteasome (prosome, macropain) activator subunit 4 2.09075
JAG2 jagged 2 2.08597
TUFT1 tuftelin 1 2.0768
IGF1R insulin-like growth factor 1 receptor 2.06907
S100A12 S100 calcium binding protein A12 2.0689
SPRR1A small proline-rich protein 1A 2.06747
GRM6 glutamate receptor, metabotropic 6 2.0638
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.06262
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 2.0609
RLN1 relaxin 1 2.06015
SF3B2 splicing factor 3b, subunit 2, 145kDa 2.0592
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.05695
COL16A1 collagen, type XVI, alpha 1 2.05525
MFAP2 microfibrillar-associated protein 2 2.0547
TBC1D10B TBC1 domain family, member 10B 2.0525
OSBPL3 oxysterol binding protein-like 3 2.0525
ZNF780A zinc finger protein 780A 2.05225
LOC124906748 beta-defensin 4A 2.0511
IGF1 insulin-like growth factor 1 (somatomedin C) 2.04872
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2.047
ILF2 interleukin enhancer binding factor 2 2.04345
PKN1 protein kinase N1 2.04265
HABP2 hyaluronan binding protein 2 2.0423
OR1A1 olfactory receptor, family 1, subfamily A, member 1 2.0363
SPTBN2 spectrin, beta, non-erythrocytic 2 2.0354
CD34 CD34 molecule 2.03485
LMAN1 lectin, mannose-binding, 1 2.0276
SHROOM2 shroom family member 2 2.02705
WDFY3 WD repeat and FYVE domain containing 3 2.0267
ITPKB inositol-trisphosphate 3-kinase B 2.0238
LIMK2 LIM domain kinase 2 2.02035
VSNL1 visinin-like 1 2.02003
MAP7D1 MAP7 domain containing 1 2.01875
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.0152
CPTP ceramide-1-phosphate transfer protein 2.015
MOBP myelin-associated oligodendrocyte basic protein 2.01447
MAPK1 mitogen-activated protein kinase 1 2.01358
PYGM phosphorylase, glycogen, muscle 2.01135
CATSPERB catsper channel auxiliary subunit beta 2.01125
SELE selectin E 2.0071
PPP6R1 protein phosphatase 6, regulatory subunit 1 2.00525
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 2.00437
MTERF3 mitochondrial transcription termination factor 3 2.0025
RGPD2 RANBP2-like and GRIP domain containing 2 2.00165
GLI1 GLI family zinc finger 1 2.0

decreased expression

Symbol Name Standardized Value
LOC124907782 dual specificity protein phosphatase 22 -8.7534
MRPS2 mitochondrial ribosomal protein S2 -5.77455
ZDHHC6 zinc finger, DHHC-type containing 6 -5.67075
PGAM4 phosphoglycerate mutase family member 4 -5.46205
DERA deoxyribose-phosphate aldolase (putative) -5.0703
PCNA proliferating cell nuclear antigen -4.9354
UGDH UDP-glucose 6-dehydrogenase -4.8863
CASP3 caspase 3, apoptosis-related cysteine peptidase -4.8859
NUP85 nucleoporin 85kDa -4.87345
DYNLT3 dynein, light chain, Tctex-type 3 -4.85455
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.8327
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.74175
ACOT9 acyl-CoA thioesterase 9 -4.73315
GTPBP8 GTP-binding protein 8 (putative) -4.73165
SYNE2 spectrin repeat containing, nuclear envelope 2 -4.60545
LDHD lactate dehydrogenase D -4.5741
ETFB electron-transfer-flavoprotein, beta polypeptide -4.49475
MRPS16 mitochondrial ribosomal protein S16 -4.48385
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -4.39645
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.33615
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.30085
THAP11 THAP domain containing 11 -4.28685
CD58 CD58 molecule -4.28597
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -4.2577
PYCR1 pyrroline-5-carboxylate reductase 1 -4.20825
ZMIZ1 zinc finger, MIZ-type containing 1 -4.15705
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -4.03597
PDIA5 protein disulfide isomerase family A, member 5 -4.03475
DSG2 desmoglein 2 -3.99065
HSPB1 heat shock 27kDa protein 1 -3.9816
SNX11 sorting nexin 11 -3.97937
TXNDC15 thioredoxin domain containing 15 -3.97385
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -3.87065
RPIA ribose 5-phosphate isomerase A -3.75445
PRCP prolylcarboxypeptidase (angiotensinase C) -3.7198
FGFR4 fibroblast growth factor receptor 4 -3.70782
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -3.7015
MTA1 metastasis associated 1 -3.6806
FDXR ferredoxin reductase -3.56855
TMEM109 transmembrane protein 109 -3.54925
TM9SF3 transmembrane 9 superfamily member 3 -3.51315
GNAS GNAS complex locus -3.48324
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.45825
TOMM34 translocase of outer mitochondrial membrane 34 -3.4472
SSR1 signal sequence receptor, alpha -3.37924
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -3.30425
MRPL58 mitochondrial ribosomal protein L58 -3.29015
FUBP3 far upstream element (FUSE) binding protein 3 -3.2901
MRPS7 mitochondrial ribosomal protein S7 -3.27895
TENM3 teneurin transmembrane protein 3 -3.25555
TRADD TNFRSF1A-associated via death domain -3.2471
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough -3.21975
TMEM50A transmembrane protein 50A -3.2125
ANKRD10 ankyrin repeat domain 10 -3.2115
FOS FBJ murine osteosarcoma viral oncogene homolog -3.168
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -3.1637
CDHR2 cadherin-related family member 2 -3.1452
SPAG4 sperm associated antigen 4 -3.10215
GPC1 glypican 1 -3.05227
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 -3.04795
BICRAL BICRA like chromatin remodeling complex associated protein -3.01487
HEXB hexosaminidase B (beta polypeptide) -3.00865
NT5DC2 5'-nucleotidase domain containing 2 -3.0003
RABEPK Rab9 effector protein with kelch motifs -2.99105
JUN jun proto-oncogene -2.97838
SUMO4 small ubiquitin-like modifier 4 -2.96125
INHBE inhibin, beta E -2.93695
VKORC1 vitamin K epoxide reductase complex, subunit 1 -2.9055
CRYZ crystallin, zeta (quinone reductase) -2.8934
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -2.88825
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) -2.8755
PDLIM1 PDZ and LIM domain 1 -2.8516
PHOX2A paired-like homeobox 2a -2.8516
NOL11 nucleolar protein 11 -2.84275
NME3 NME/NM23 nucleoside diphosphate kinase 3 -2.8404
TMEM97 transmembrane protein 97 -2.82787
ISOC1 isochorismatase domain containing 1 -2.822
KANSL1 KAT8 regulatory NSL complex subunit 1 -2.8216
GMPPA GDP-mannose pyrophosphorylase A -2.8216
TK2 thymidine kinase 2, mitochondrial -2.82007
CIDEC cell death-inducing DFFA-like effector c -2.80185
ATF5 activating transcription factor 5 -2.7915
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -2.78805
PRKCD protein kinase C, delta -2.7832
GZMM granzyme M (lymphocyte met-ase 1) -2.771
GAST gastrin -2.76995
RBKS ribokinase -2.7677
OCEL1 occludin/ELL domain containing 1 -2.7673
JPT1 Jupiter microtubule associated homolog 1 -2.7658
RTN3 reticulon 3 -2.75575
NLGN3 neuroligin 3 -2.75205
BUB3 BUB3 mitotic checkpoint protein -2.75115
LYRM9 LYR motif containing 9 -2.74955
ANXA5 annexin A5 -2.74885
RPN1 ribophorin I -2.7436
NPM3 nucleophosmin/nucleoplasmin 3 -2.7432
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 -2.7387
ARID3A AT rich interactive domain 3A (BRIGHT-like) -2.73845
MSH5 mutS homolog 5 -2.7263
GAA glucosidase, alpha; acid -2.7237
SERF1A small EDRK-rich factor 1A (telomeric) -2.6933
OARD1 O-acyl-ADP-ribose deacylase 1 -2.68995
PTPN6 protein tyrosine phosphatase, non-receptor type 6 -2.68905
SNX15 sorting nexin 15 -2.66545
IL2RG interleukin 2 receptor, gamma -2.6637
IGFLR1 IGF-like family receptor 1 -2.65925
WBP1L WW domain binding protein 1-like -2.65475
GPN3 GPN-loop GTPase 3 -2.65445
ASDURF ASNSD1 upstream open reading frame -2.6522
MPPED2 metallophosphoesterase domain containing 2 -2.6471
SMG8 SMG8 nonsense mediated mRNA decay factor -2.63055
OSTM1 osteopetrosis associated transmembrane protein 1 -2.62285
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.62155
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.61688
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -2.6161
GAP43 growth associated protein 43 -2.6151
HAND1 heart and neural crest derivatives expressed 1 -2.6017
LYRM4 LYR motif containing 4 -2.60045
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.5997
HSPE1 heat shock 10kDa protein 1 -2.5884
PHF2 PHD finger protein 2 -2.57815
TBPL1 TBP-like 1 -2.56925
CLEC10A C-type lectin domain family 10, member A -2.56615
SFXN1 sideroflexin 1 -2.56295
PALLD palladin, cytoskeletal associated protein -2.5629
FOXB1 forkhead box B1 -2.5562
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.55548
SAP30 Sin3A-associated protein, 30kDa -2.5537
CCL23 chemokine (C-C motif) ligand 23 -2.55157
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -2.5455
MGST3 microsomal glutathione S-transferase 3 -2.5379
APOB apolipoprotein B -2.53465
TMEM74B transmembrane protein 74B -2.53325
NLRP4 NLR family, pyrin domain containing 4 -2.52595
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -2.5162
FAT1 FAT atypical cadherin 1 -2.5127
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 -2.50645
ACAA1 acetyl-CoA acyltransferase 1 -2.50362
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 -2.50255
CTSB cathepsin B -2.50185
UBE2O ubiquitin-conjugating enzyme E2O -2.49355
CLCN6 chloride channel, voltage-sensitive 6 -2.48705
APOC3 apolipoprotein C-III -2.4835
TM9SF2 transmembrane 9 superfamily member 2 -2.48295
SPEG SPEG complex locus -2.47095
C1GALT1C1 C1GALT1-specific chaperone 1 -2.46645
CENPT centromere protein T -2.4644
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.46035
RTN2 reticulon 2 -2.45677
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.45523
ASGR1 asialoglycoprotein receptor 1 -2.45415
FBP1 fructose-1,6-bisphosphatase 1 -2.4473
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.4444
PRDX4 peroxiredoxin 4 -2.4239
HOOK3 hook microtubule-tethering protein 3 -2.4219
TICAM1 toll-like receptor adaptor molecule 1 -2.42155
MUTYH mutY homolog -2.41745
IL32 interleukin 32 -2.41085
ATRAID all-trans retinoic acid-induced differentiation factor -2.4031
DOCK2 dedicator of cytokinesis 2 -2.39635
ANGPTL8 angiopoietin like 8 -2.38495
AGRP agouti related neuropeptide -2.3845
ZFR2 zinc finger RNA binding protein 2 -2.3815
TKFC triokinase/FMN cyclase -2.38005
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) -2.37965
SDC3 syndecan 3 -2.3775
ARHGAP29 Rho GTPase activating protein 29 -2.3766
FBXL8 F-box and leucine-rich repeat protein 8 -2.37505
TXNL4B thioredoxin-like 4B -2.37485
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like -2.3741
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -2.3728
EXOSC8 exosome component 8 -2.37275
A1CF APOBEC1 complementation factor -2.37105
IL17B interleukin 17B -2.36285
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -2.36145
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -2.36115
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -2.354
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -2.3498
ADGRB3 adhesion G protein-coupled receptor B3 -2.3455
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) -2.34345
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.34095
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.323
RAI14 retinoic acid induced 14 -2.3187
AURKA aurora kinase A -2.3169
DGAT1 diacylglycerol O-acyltransferase 1 -2.30705
ITGAV integrin, alpha V -2.3068
TMEM94 transmembrane protein 94 -2.3054
CEPT1 choline/ethanolamine phosphotransferase 1 -2.2949
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -2.29325
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 -2.29245
STX8 syntaxin 8 -2.28835
PFAS phosphoribosylformylglycinamidine synthase -2.2807
NECAP2 NECAP endocytosis associated 2 -2.2774
TMEM14B transmembrane protein 14B -2.27725
EIF3A eukaryotic translation initiation factor 3, subunit A -2.26802
MTA2 metastasis associated 1 family, member 2 -2.26685
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -2.26675
FRS3 fibroblast growth factor receptor substrate 3 -2.26525
SCAMP5 secretory carrier membrane protein 5 -2.2638
EVI2B ecotropic viral integration site 2B -2.25985
MAT2B methionine adenosyltransferase II, beta -2.2572
NPTN neuroplastin -2.2548
MED22 mediator complex subunit 22 -2.2537
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -2.25318
TNMD tenomodulin -2.25315
AP3B2 adaptor-related protein complex 3, beta 2 subunit -2.24965
SCG3 secretogranin III -2.248
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -2.24622
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -2.24375
RRAGA Ras-related GTP binding A -2.22895
RBMS3 RNA binding motif, single stranded interacting protein 3 -2.22385
IGF2R insulin-like growth factor 2 receptor -2.22365
SSTR5 somatostatin receptor 5 -2.2223
PRELID3B PRELI domain containing 3B -2.2222
WNT1 wingless-type MMTV integration site family, member 1 -2.2221
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 -2.22155
ATP5PD ATP synthase peripheral stalk subunit d -2.2127
KCTD3 potassium channel tetramerization domain containing 3 -2.2116
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide -2.20795
RNF13 ring finger protein 13 -2.20318
CCL17 chemokine (C-C motif) ligand 17 -2.19915
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit -2.196
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.19485
SELENOT selenoprotein T -2.1907
ASGR2 asialoglycoprotein receptor 2 -2.18985
RMI1 RecQ mediated genome instability 1 -2.1892
HTN3 histatin 3 -2.18835
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.1851
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.1798
BLM Bloom syndrome, RecQ helicase-like -2.17875
SLC35A5 solute carrier family 35, member A5 -2.1762
FPGT fucose-1-phosphate guanylyltransferase -2.17435
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.17405
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.17385
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -2.17325
PSKH1 protein serine kinase H1 -2.17065
TMEM59 transmembrane protein 59 -2.1683
TBCCD1 TBCC domain containing 1 -2.1645
GPR17 G protein-coupled receptor 17 -2.16342
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -2.15755
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 -2.15658
LBX1 ladybird homeobox 1 -2.1548
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.1548
UNC50 unc-50 homolog (C. elegans) -2.1531
GPR37L1 G protein-coupled receptor 37 like 1 -2.1524
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -2.1518
LRRC40 leucine rich repeat containing 40 -2.1494
ABAT 4-aminobutyrate aminotransferase -2.14818
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 -2.14705
TSPAN7 tetraspanin 7 -2.14335
CES2 carboxylesterase 2 -2.1419
TIMP1 TIMP metallopeptidase inhibitor 1 -2.1409
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.1405
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.14035
TMEM255A transmembrane protein 255A -2.1396
APOA1 apolipoprotein A-I -2.1394
NOL7 nucleolar protein 7, 27kDa -2.13677
GRB2 growth factor receptor-bound protein 2 -2.13375
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 -2.13348
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.12908
FNDC3B fibronectin type III domain containing 3B -2.126
ARHGAP6 Rho GTPase activating protein 6 -2.1244
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase -2.121
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -2.12027
ATP5MC1 ATP synthase membrane subunit c locus 1 -2.11545
MCOLN1 mucolipin 1 -2.109
FAM131B family with sequence similarity 131, member B -2.10805
RAB33A RAB33A, member RAS oncogene family -2.10475
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 -2.0927
STX11 syntaxin 11 -2.0922
TSPAN12 tetraspanin 12 -2.09215
CYB5R3 cytochrome b5 reductase 3 -2.0885
TMEM176A transmembrane protein 176A -2.08605
TFAM transcription factor A, mitochondrial -2.0857
RSAD1 radical S-adenosyl methionine domain containing 1 -2.08505
EIF4A2 eukaryotic translation initiation factor 4A2 -2.08495
GMEB2 glucocorticoid modulatory element binding protein 2 -2.08007
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) -2.07535
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -2.07055
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 -2.0666
RTL8C retrotransposon Gag like 8C -2.06505
SIX6 SIX homeobox 6 -2.06395
RAP1GAP RAP1 GTPase activating protein -2.06365
PA2G4 proliferation-associated 2G4, 38kDa -2.06312
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 -2.0628
FAM222B family with sequence similarity 222, member B -2.06155
ZNF706 zinc finger protein 706 -2.0608
LUC7L3 LUC7-like 3 (S. cerevisiae) -2.05975
ANAPC2 anaphase promoting complex subunit 2 -2.0591
RAI2 retinoic acid induced 2 -2.05765
HYOU1 hypoxia up-regulated 1 -2.05715
IL27RA interleukin 27 receptor, alpha -2.05355
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) -2.0502
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled -2.0498
CKLF-CMTM1 CKLF-CMTM1 readthrough -2.04722
ALG3 ALG3, alpha-1,3- mannosyltransferase -2.0469
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.0451
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -2.0436
CIAO2B cytosolic iron-sulfur assembly component 2B -2.0424
AUNIP aurora kinase A and ninein interacting protein -2.041
HELZ helicase with zinc finger -2.04065
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 -2.03415
CNPY2 canopy FGF signaling regulator 2 -2.03278
RFC4 replication factor C (activator 1) 4, 37kDa -2.02955
TBXAS1 thromboxane A synthase 1 (platelet) -2.02905
PRSS23 protease, serine, 23 -2.0285
TMEM208 transmembrane protein 208 -2.0283
BEGAIN brain-enriched guanylate kinase-associated -2.02695
LMBR1L limb development membrane protein 1-like -2.02465
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.0242
TMEM14A transmembrane protein 14A -2.0228
RUNDC3A RUN domain containing 3A -2.02143
TEX14 testis expressed 14 -2.0211
GLT8D1 glycosyltransferase 8 domain containing 1 -2.02105
BPTF bromodomain PHD finger transcription factor -2.01892
ORM2 orosomucoid 2 -2.01635
HTN1 histatin 1 -2.01405
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.01215
CAMK4 calcium/calmodulin-dependent protein kinase IV -2.01025
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 -2.00948
IFRD2 interferon-related developmental regulator 2 -2.0073
CHAD chondroadherin -2.00645
CTSA cathepsin A -2.0049
STAB2 stabilin 2 -2.00385
TMEM100 transmembrane protein 100 -2.0022
HNRNPR heterogeneous nuclear ribonucleoprotein R -2.001