CRCGN012_HEPG2_24H:L16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description safrole 5.03 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN012_HEPG2_24H:L16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ANO1 anoctamin 1, calcium activated chloride channel 7.68411
STIMATE STIM activating enhancer 5.09305
MYLK myosin light chain kinase 4.70619
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.59785
ATP11B ATPase, class VI, type 11B 4.34379
PPARG peroxisome proliferator-activated receptor gamma 4.20704
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.1172
LOC122526780 uncharacterized LOC122526780 4.11002
CCNA1 cyclin A1 4.10722
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.08115
STK10 serine/threonine kinase 10 3.8835
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.46826
CBR3 carbonyl reductase 3 3.46396
CIAO3 cytosolic iron-sulfur assembly component 3 3.27128
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.04089
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.96267
BPHL biphenyl hydrolase-like (serine hydrolase) 2.88268
PHKG2 phosphorylase kinase, gamma 2 (testis) 2.79729
EVL Enah/Vasp-like 2.74667
RRAGA Ras-related GTP binding A 2.74375
WDTC1 WD and tetratricopeptide repeats 1 2.7344
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.66098
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.56202
PKN1 protein kinase N1 2.54484
SHB Src homology 2 domain containing adaptor protein B 2.47938
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.44553
MTERF3 mitochondrial transcription termination factor 3 2.41833
CYCS cytochrome c, somatic 2.27317
DYNLT3 dynein, light chain, Tctex-type 3 2.20166
SCUBE2 signal peptide, CUB domain, EGF-like 2 2.187
NPDC1 neural proliferation, differentiation and control, 1 2.07878
PLSCR1 phospholipid scramblase 1 2.01926

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.3537
KDM3A lysine (K)-specific demethylase 3A -4.29339
CDC20 cell division cycle 20 -4.02741
DNM1L dynamin 1-like -4.00517
GTPBP8 GTP-binding protein 8 (putative) -3.91119
ADI1 acireductone dioxygenase 1 -3.86603
LDHD lactate dehydrogenase D -3.66129
PCNA proliferating cell nuclear antigen -3.63327
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.45878
RFC2 replication factor C (activator 1) 2, 40kDa -3.41222
OXA1L oxidase (cytochrome c) assembly 1-like -2.93626
MAPK13 mitogen-activated protein kinase 13 -2.6669
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.55057
SNX11 sorting nexin 11 -2.49157
CCNB2 cyclin B2 -2.46852
SESN1 sestrin 1 -2.38614
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.25729
BIRC2 baculoviral IAP repeat containing 2 -2.15653
CCDC86 coiled-coil domain containing 86 -2.123
SETMAR SET domain and mariner transposase fusion gene -2.0025
NEUROD1 neuronal differentiation 1 -2.00056