| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | urea 42.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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57 genes differentially expressed following the CRCGN012_HEPG2_24H:L19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| E2F2 | E2F transcription factor 2 | 8.47796 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 6.55704 |
| MOK | MOK protein kinase | 6.53562 |
| PPARG | peroxisome proliferator-activated receptor gamma | 6.27951 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 6.08572 |
| CYCS | cytochrome c, somatic | 5.86913 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 5.19134 |
| NOTCH1 | notch 1 | 5.14233 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 5.06412 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 4.90767 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 4.77863 |
| PNKP | polynucleotide kinase 3'-phosphatase | 4.02302 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 4.00876 |
| TXNL4B | thioredoxin-like 4B | 3.42821 |
| PRKCH | protein kinase C, eta | 3.26391 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.25889 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 2.85352 |
| CCNF | cyclin F | 2.78933 |
| HDGFL3 | HDGF like 3 | 2.70437 |
| NOSIP | nitric oxide synthase interacting protein | 2.66296 |
| GSTM5 | glutathione S-transferase mu 5 | 2.65041 |
| EVL | Enah/Vasp-like | 2.49165 |
| DENND5B | DENN/MADD domain containing 5B | 2.48043 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 2.44273 |
| JADE3 | jade family PHD finger 3 | 2.43868 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.29044 |
| TBC1D12 | TBC1 domain family, member 12 | 2.233 |
| THSD7A | thrombospondin, type I, domain containing 7A | 2.13998 |
| SLC75A1 | solute carrier family 75 member 1 | 2.10263 |
| TBP | TATA box binding protein | 2.09557 |
| HOXC6 | homeobox C6 | 2.07967 |
| USP13 | ubiquitin specific peptidase 13 (isopeptidase T-3) | 2.04098 |
| MGAT4C | MGAT4 family, member C | 2.01261 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -8.52287 |
| LAP3 | leucine aminopeptidase 3 | -5.7777 |
| SMNDC1 | survival motor neuron domain containing 1 | -5.68111 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -5.36285 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -5.1702 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -5.06384 |
| ADI1 | acireductone dioxygenase 1 | -4.84327 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -4.80617 |
| KDM3A | lysine (K)-specific demethylase 3A | -4.7927 |
| PCNA | proliferating cell nuclear antigen | -3.76744 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.50916 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.01451 |
| CCNB2 | cyclin B2 | -2.9778 |
| LYPLA1 | lysophospholipase I | -2.96774 |
| CCNH | cyclin H | -2.64958 |
| VDAC1 | voltage-dependent anion channel 1 | -2.60484 |
| DERA | deoxyribose-phosphate aldolase (putative) | -2.56135 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -2.47634 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.31688 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.16977 |
| CRYZL1 | crystallin, zeta (quinone reductase)-like 1 | -2.07115 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.04633 |
| CPNE3 | copine III | -2.01162 |
| CLTC | clathrin, heavy chain (Hc) | -2.00147 |
