CRCGN012_HEPG2_24H:L20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description urea 21.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN012_HEPG2_24H:L20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.83287
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.8286
DYNLT3 dynein, light chain, Tctex-type 3 4.60776
SYNE2 spectrin repeat containing, nuclear envelope 2 4.33347
AMDHD2 amidohydrolase domain containing 2 4.26728
ADRB2 adrenoceptor beta 2, surface 4.26136
PPARG peroxisome proliferator-activated receptor gamma 4.25455
UBQLN2 ubiquilin 2 4.17873
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.12676
CXCL2 chemokine (C-X-C motif) ligand 2 3.95025
CBR3 carbonyl reductase 3 3.92662
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.86881
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.8419
CHN1 chimerin 1 3.77915
PNKP polynucleotide kinase 3'-phosphatase 3.76233
STIMATE STIM activating enhancer 3.52054
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.32459
CYCS cytochrome c, somatic 2.81084
H2BC12 H2B clustered histone 12 2.79952
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.65718
JADE2 jade family PHD finger 2 2.33868
TIAM1 T-cell lymphoma invasion and metastasis 1 2.20933
NPDC1 neural proliferation, differentiation and control, 1 2.19162
ZFP36 ZFP36 ring finger protein 2.05515
CCNF cyclin F 2.02353

decreased expression

Symbol Name Standardized Value
FBXL12 F-box and leucine-rich repeat protein 12 -7.56295
FGFR4 fibroblast growth factor receptor 4 -4.49063
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.40111
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.36395
ADI1 acireductone dioxygenase 1 -4.14642
TRIB3 tribbles pseudokinase 3 -3.88098
SPAG4 sperm associated antigen 4 -3.23813
TLCD3A TLC domain containing 3A -2.84494
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.82235
ICAM3 intercellular adhesion molecule 3 -2.72287
RPS5 ribosomal protein S5 -2.48669
LOC124907782 dual specificity protein phosphatase 22 -2.48619
MACF1 microtubule-actin crosslinking factor 1 -2.48431
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.42249
DENND2B DENN domain containing 2B -2.36233
STAT5A signal transducer and activator of transcription 5A -2.16187
GDF15 growth differentiation factor 15 -2.16035
KLHL21 kelch-like family member 21 -2.1502