CRCGN012_HEPG2_24H:L21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description urea 10.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

64 genes differentially expressed following the CRCGN012_HEPG2_24H:L21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 10.0
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 8.66219
TIAM1 T-cell lymphoma invasion and metastasis 1 5.86146
PNKP polynucleotide kinase 3'-phosphatase 5.50655
MCOLN1 mucolipin 1 4.5836
CHMP6 charged multivesicular body protein 6 4.39338
CSK c-src tyrosine kinase 3.97939
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.8094
GSTZ1 glutathione S-transferase zeta 1 3.56562
RPP38 ribonuclease P/MRP 38kDa subunit 3.44434
JADE2 jade family PHD finger 2 3.41281
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.10962
CYCS cytochrome c, somatic 2.9456
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.86616
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.73573
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.68787
NOSIP nitric oxide synthase interacting protein 2.64311
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.43254
ABHD6 abhydrolase domain containing 6 2.41382
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.40278
CBR3 carbonyl reductase 3 2.40076
IL5 interleukin 5 2.38344
CCNF cyclin F 2.34775
FZD7 frizzled class receptor 7 2.24814
CCL2 chemokine (C-C motif) ligand 2 2.24793
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.22146
RAB21 RAB21, member RAS oncogene family 2.21908
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.20137
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.19375
XYLT1 xylosyltransferase I 2.16083
LUZP2 leucine zipper protein 2 2.1479
PON3 paraoxonase 3 2.13619
ATP5F1C ATP synthase F1 subunit gamma 2.13535
TRAPPC12 trafficking protein particle complex 12 2.07947
IFNA13 interferon, alpha 13 2.06656
KIF20A kinesin family member 20A 2.04246
TLR4 toll-like receptor 4 2.03931
LMCD1 LIM and cysteine-rich domains 1 2.02242
IL6 interleukin 6 2.00308

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -8.2198
CCNB2 cyclin B2 -6.05082
SLC35F2 solute carrier family 35, member F2 -4.95822
LDHD lactate dehydrogenase D -4.81865
MRPS2 mitochondrial ribosomal protein S2 -4.67375
TM9SF3 transmembrane 9 superfamily member 3 -4.40943
HMG20B high mobility group 20B -4.28519
NGRN neugrin, neurite outgrowth associated -3.91348
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.8973
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.4183
CD320 CD320 molecule -3.32556
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.078
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.04986
CCNB1 cyclin B1 -2.53564
EIF5 eukaryotic translation initiation factor 5 -2.47185
NRIP1 nuclear receptor interacting protein 1 -2.42154
RFC2 replication factor C (activator 1) 2, 40kDa -2.32077
IRF1 interferon regulatory factor 1 -2.28935
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha -2.21925
CHMP4B charged multivesicular body protein 4B -2.15515
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -2.12437
FCGBP Fc fragment of IgG binding protein -2.05143
CA2 carbonic anhydrase II -2.03312
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.01428
TSPAN12 tetraspanin 12 -2.0035