CRCGN012_HEPG2_24H:M04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vinyl acetate 5.15 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN012_HEPG2_24H:M04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 8.70964
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 5.57185
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.30755
UBQLN2 ubiquilin 2 4.80443
MYLK myosin light chain kinase 4.68241
MOK MOK protein kinase 4.38995
SFTPB surfactant protein B 4.14724
CIAO3 cytosolic iron-sulfur assembly component 3 3.99395
CHN1 chimerin 1 3.69475
PPARG peroxisome proliferator-activated receptor gamma 3.46818
NMU neuromedin U 3.3523
ABHD6 abhydrolase domain containing 6 3.11452
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.89901
TBP TATA box binding protein 2.59459
LSR lipolysis stimulated lipoprotein receptor 2.49471
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.40294
MMP1 matrix metallopeptidase 1 2.37372
PRKCH protein kinase C, eta 2.26076
CCNA1 cyclin A1 2.19166
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.11875
BAMBI BMP and activin membrane-bound inhibitor 2.08129
MTARC1 mitochondrial amidoxime reducing component 1 2.06786

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -8.78004
ZNF586 zinc finger protein 586 -8.64002
CCNB2 cyclin B2 -5.79508
ZDHHC6 zinc finger, DHHC-type containing 6 -4.17168
PEG10 paternally expressed 10 -4.12102
OXA1L oxidase (cytochrome c) assembly 1-like -3.53496
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.52379
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.41837
EGF epidermal growth factor -3.12536
FGFR4 fibroblast growth factor receptor 4 -2.84945
ZNF134 zinc finger protein 134 -2.78455
SSBP2 single-stranded DNA binding protein 2 -2.56416
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.4957
ZNF304 zinc finger protein 304 -2.48281
CCNB1 cyclin B1 -2.40649
ZNF211 zinc finger protein 211 -2.23561
COL21A1 collagen, type XXI, alpha 1 -2.2083
ZNF350 zinc finger protein 350 -2.1879
TRPS1 trichorhinophalangeal syndrome I -2.15879
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -2.13393
ZNF197 zinc finger protein 197 -2.10007
GPRASP1 G protein-coupled receptor associated sorting protein 1 -2.08347
RPS5 ribosomal protein S5 -2.02028
BMP5 bone morphogenetic protein 5 -2.00925