CRCGN012_HEPG2_24H:M07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chloroform 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN012_HEPG2_24H:M07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 5.02726
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 4.72825
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.99351
CHMP6 charged multivesicular body protein 6 3.93214
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.6334
RXYLT1 ribitol xylosyltransferase 1 3.25982
PFKL phosphofructokinase, liver 3.06849
JADE2 jade family PHD finger 2 2.69388
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.65825
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.62487
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.57326
MICALL1 MICAL-like 1 2.35559
CEP57 centrosomal protein 57kDa 2.27795
LOC122526780 uncharacterized LOC122526780 2.22241
PMM2 phosphomannomutase 2 2.14088
PIH1D1 PIH1 domain containing 1 2.08515
CPT1B carnitine palmitoyltransferase 1B (muscle) 2.00695
FRG1 FSHD region gene 1 2.00625
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 2.00002

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -9.35509
RPS4Y1 ribosomal protein S4, Y-linked 1 -5.32006
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -5.1541
LDHD lactate dehydrogenase D -5.1132
GTPBP8 GTP-binding protein 8 (putative) -4.95168
ADI1 acireductone dioxygenase 1 -4.92685
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.90603
PCNA proliferating cell nuclear antigen -4.90216
ZDHHC6 zinc finger, DHHC-type containing 6 -4.69596
ZMIZ1 zinc finger, MIZ-type containing 1 -4.67802
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.40538
MRPS2 mitochondrial ribosomal protein S2 -4.22717
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.92377
TLCD3A TLC domain containing 3A -3.58474
DERA deoxyribose-phosphate aldolase (putative) -3.23793
MAPK13 mitogen-activated protein kinase 13 -3.15354
FGFR4 fibroblast growth factor receptor 4 -3.06218
EIF5 eukaryotic translation initiation factor 5 -2.93905
CCNB1 cyclin B1 -2.86564
FAT1 FAT atypical cadherin 1 -2.50635
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.4416
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.43868
GNAS GNAS complex locus -2.35863
XPO7 exportin 7 -2.29341
KEAP1 kelch-like ECH-associated protein 1 -2.17802
PRELP proline/arginine-rich end leucine-rich repeat protein -2.14998
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.12573
F5 coagulation factor V (proaccelerin, labile factor) -2.09996
ZNF706 zinc finger protein 706 -2.09965
THBS2 thrombospondin 2 -2.0718
NLGN4Y neuroligin 4, Y-linked -2.06406
OR1E2 olfactory receptor, family 1, subfamily E, member 2 -2.03982
OR7A17 olfactory receptor, family 7, subfamily A, member 17 -2.03942
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 -2.01324
SV2C synaptic vesicle glycoprotein 2C -2.00464