CRCGN012_HEPG2_24H:M09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chloroform 9.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN012_HEPG2_24H:M09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BZW2 basic leucine zipper and W2 domains 2 9.01136
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.39981
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.71092
STAP2 signal transducing adaptor family member 2 4.57953
GPER1 G protein-coupled estrogen receptor 1 4.39515
CHMP6 charged multivesicular body protein 6 4.26336
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.22653
HOXA10 homeobox A10 3.94842
SNAP25 synaptosomal-associated protein, 25kDa 3.33527
VGLL4 vestigial-like family member 4 3.29552
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 3.28174
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.23412
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 3.18938
FZD7 frizzled class receptor 7 3.03155
DENND2D DENN/MADD domain containing 2D 2.75881
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.6855
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.62872
CCNF cyclin F 2.59881
ZNF589 zinc finger protein 589 2.59388
TIAM1 T-cell lymphoma invasion and metastasis 1 2.50725
LCN2 lipocalin 2 2.47965
CYCS cytochrome c, somatic 2.40358
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase 2.20146
ZNF91 zinc finger protein 91 2.19127
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.11295
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.11181
GSTT1 glutathione S-transferase theta 1 2.01642
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.00681

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -9.00793
ZMIZ1 zinc finger, MIZ-type containing 1 -5.70719
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.59179
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.93696
DNM1L dynamin 1-like -4.79587
LAP3 leucine aminopeptidase 3 -4.79426
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -4.77499
FASTKD5 FAST kinase domains 5 -4.63286
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -4.5984
VAT1 vesicle amine transport 1 -4.57064
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.56519
HAT1 histone acetyltransferase 1 -4.49281
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -4.48365
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -4.47088
GDF15 growth differentiation factor 15 -4.23729
TRIB3 tribbles pseudokinase 3 -4.23223
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.89879
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.87013
SLC35F2 solute carrier family 35, member F2 -3.85129
MAPK13 mitogen-activated protein kinase 13 -3.80925
SNX11 sorting nexin 11 -3.60085
MTA1 metastasis associated 1 -3.29036
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.63208
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.62027
SEM1 SEM1 26S proteasome subunit -2.54936
HLA-DMA major histocompatibility complex, class II, DM alpha -2.49731
TBCB tubulin folding cofactor B -2.45464
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -2.34993
XPO7 exportin 7 -2.32206
CCP110 centriolar coiled coil protein 110kDa -2.27162
CAPNS1 calpain, small subunit 1 -2.26849
TMEM147 transmembrane protein 147 -2.23164
TM9SF3 transmembrane 9 superfamily member 3 -2.20849
LIN37 lin-37 DREAM MuvB core complex component -2.18342
EGF epidermal growth factor -2.17695
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 -2.17532
KIAA0232 KIAA0232 -2.15685
MRPL18 mitochondrial ribosomal protein L18 -2.11038
PDCD5 programmed cell death 5 -2.09148
FKBP4 FK506 binding protein 4, 59kDa -2.05157
UFD1 ubiquitin recognition factor in ER associated degradation 1 -2.00802