CRCGN012_HEPG2_24H:M12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chloroform 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN012_HEPG2_24H:M12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIAM1 T-cell lymphoma invasion and metastasis 1 6.59676
PPARG peroxisome proliferator-activated receptor gamma 5.97073
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.52731
GPATCH8 G patch domain containing 8 4.88345
EPHB2 EPH receptor B2 4.70515
MOK MOK protein kinase 4.50315
ATP11B ATPase, class VI, type 11B 4.36189
LCN2 lipocalin 2 4.23728
MYLK myosin light chain kinase 4.14828
CXCL2 chemokine (C-X-C motif) ligand 2 4.0375
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 3.8618
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.78813
LOC122526780 uncharacterized LOC122526780 3.73413
CYCS cytochrome c, somatic 3.48881
CBR3 carbonyl reductase 3 3.32494
TBP TATA box binding protein 3.27259
CCNA1 cyclin A1 3.13401
PMM2 phosphomannomutase 2 2.93002
ABHD4 abhydrolase domain containing 4 2.92276
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.66317
PFKL phosphofructokinase, liver 2.62365
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.6159
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.56942
BLMH bleomycin hydrolase 2.44029
EVL Enah/Vasp-like 2.41773
NECAB3 N-terminal EF-hand calcium binding protein 3 2.41047
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.10483
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.09112
CAAP1 caspase activity and apoptosis inhibitor 1 2.08783
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.05114
PNKP polynucleotide kinase 3'-phosphatase 2.04876
AUH AU RNA binding protein/enoyl-CoA hydratase 2.0385
LHFPL6 LHFPL tetraspan subfamily member 6 2.0183

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -7.90443
ZNF586 zinc finger protein 586 -4.26772
DUSP6 dual specificity phosphatase 6 -4.22978
KDM3A lysine (K)-specific demethylase 3A -3.87002
CDC20 cell division cycle 20 -3.75857
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.75412
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.75235
CCNB2 cyclin B2 -3.56695
CHMP4B charged multivesicular body protein 4B -3.25093
MAPK13 mitogen-activated protein kinase 13 -3.11654
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.91264
TBCB tubulin folding cofactor B -2.82137
PEG10 paternally expressed 10 -2.7983
HMG20B high mobility group 20B -2.66692
NR2C2 nuclear receptor subfamily 2, group C, member 2 -2.22669
ERCC1 excision repair cross-complementation group 1 -2.06817
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.0593
PTPRK protein tyrosine phosphatase, receptor type, K -2.04
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -2.02068
PTPRN protein tyrosine phosphatase, receptor type, N -2.00612