CRCGN012_HEPG2_24H:M15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,2',5,5'-tetrachlorobenzidine 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

207 genes differentially expressed following the CRCGN012_HEPG2_24H:M15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIMP2 TIMP metallopeptidase inhibitor 2 9.28391
MVP major vault protein 6.59216
ACOT9 acyl-CoA thioesterase 9 5.63206
FOSL1 FOS-like antigen 1 5.30979
GRB10 growth factor receptor-bound protein 10 4.79574
CNPY3 canopy FGF signaling regulator 3 4.65216
KIFBP kinesin family binding protein 4.46406
DSG2 desmoglein 2 4.23302
PLS1 plastin 1 4.12409
SQOR sulfide quinone oxidoreductase 4.03242
ZW10 zw10 kinetochore protein 3.96122
CXCR4 chemokine (C-X-C motif) receptor 4 3.96107
LCN2 lipocalin 2 3.95998
TOMM34 translocase of outer mitochondrial membrane 34 3.95821
LRP10 low density lipoprotein receptor-related protein 10 3.8242
CAB39 calcium binding protein 39 3.72569
MPC2 mitochondrial pyruvate carrier 2 3.62881
UBE2L6 ubiquitin-conjugating enzyme E2L 6 3.62462
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.61021
INPP1 inositol polyphosphate-1-phosphatase 3.59907
CCDC92 coiled-coil domain containing 92 3.5651
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.47211
TUBB6 tubulin, beta 6 class V 3.46914
SYNE2 spectrin repeat containing, nuclear envelope 2 3.43923
GPER1 G protein-coupled estrogen receptor 1 3.43721
SOCS2 suppressor of cytokine signaling 2 3.42197
STX1A syntaxin 1A (brain) 3.39221
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 3.39048
PNKP polynucleotide kinase 3'-phosphatase 3.38129
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.36891
ZNF586 zinc finger protein 586 3.35039
H2BC12 H2B clustered histone 12 3.32246
ATP11B ATPase, class VI, type 11B 3.32018
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 3.31283
NPDC1 neural proliferation, differentiation and control, 1 3.26463
RALB v-ral simian leukemia viral oncogene homolog B 3.26316
VAT1 vesicle amine transport 1 3.2487
S100A4 S100 calcium binding protein A4 3.2122
STIMATE STIM activating enhancer 3.18363
IL4R interleukin 4 receptor 3.16451
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.14902
FASTKD5 FAST kinase domains 5 3.10529
H2BC21 H2B clustered histone 21 3.07701
EPHB2 EPH receptor B2 3.05819
PRKCQ protein kinase C, theta 2.94442
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.94118
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.93259
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.7666
EDN1 endothelin 1 2.73784
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.71108
COG7 component of oligomeric golgi complex 7 2.70544
CFLAR CASP8 and FADD-like apoptosis regulator 2.65842
SFTPB surfactant protein B 2.65117
IER3 immediate early response 3 2.64973
HSPA1A heat shock 70kDa protein 1A 2.63292
CDPF1 cysteine-rich, DPF motif domain containing 1 2.62848
ANO1 anoctamin 1, calcium activated chloride channel 2.59606
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.58493
SQSTM1 sequestosome 1 2.57979
TEX10 testis expressed 10 2.55698
MICALL1 MICAL-like 1 2.52875
CLTB clathrin, light chain B 2.51619
SLC35F2 solute carrier family 35, member F2 2.51326
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.50364
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.49501
BACE2 beta-site APP-cleaving enzyme 2 2.4843
PRR15L proline rich 15-like 2.3686
SMIM40 small integral membrane protein 40 2.3473
OSBPL3 oxysterol binding protein-like 3 2.34452
LAMC2 laminin, gamma 2 2.33878
MYLK myosin light chain kinase 2.32034
LOC122526780 uncharacterized LOC122526780 2.30707
RPP38 ribonuclease P/MRP 38kDa subunit 2.29608
DYNLT3 dynein, light chain, Tctex-type 3 2.29602
CCDC85B coiled-coil domain containing 85B 2.29575
CEMIP2 cell migration inducing hyaluronidase 2 2.28383
BYSL bystin-like 2.25978
GADD45A growth arrest and DNA-damage-inducible, alpha 2.24274
TXNRD1 thioredoxin reductase 1 2.24084
SOX4 SRY (sex determining region Y)-box 4 2.21777
KLHL21 kelch-like family member 21 2.18593
LSR lipolysis stimulated lipoprotein receptor 2.17711
BAMBI BMP and activin membrane-bound inhibitor 2.17495
KDR kinase insert domain receptor 2.17356
SLC75A1 solute carrier family 75 member 1 2.17132
HTRA1 HtrA serine peptidase 1 2.16114
CBR3 carbonyl reductase 3 2.16044
GPN2 GPN-loop GTPase 2 2.14172
AXL AXL receptor tyrosine kinase 2.13934
TRAK2 trafficking protein, kinesin binding 2 2.13854
PLEK2 pleckstrin 2 2.13479
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.12993
CDC45 cell division cycle 45 2.09719
DYSF dysferlin 2.08872
H2BC9 H2B clustered histone 9 2.08686
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.06759
NUP93 nucleoporin 93kDa 2.06704
JOSD1 Josephin domain containing 1 2.0245
MTMR6 myotubularin related protein 6 2.02091
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.01614
ANXA3 annexin A3 2.01436
VGLL4 vestigial-like family member 4 2.0124
CTSL cathepsin L 2.00672
AOC1 amine oxidase, copper containing 1 2.00263

decreased expression

Symbol Name Standardized Value
ISOC1 isochorismatase domain containing 1 -7.64602
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -6.517
KDM3A lysine (K)-specific demethylase 3A -5.89078
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.83878
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -5.82859
B4GAT1 beta-1,4-glucuronyltransferase 1 -5.72894
PGM1 phosphoglucomutase 1 -5.40905
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.34444
PECR peroxisomal trans-2-enoyl-CoA reductase -5.2326
UGDH UDP-glucose 6-dehydrogenase -5.20053
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -5.06894
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.79727
TOP2A topoisomerase (DNA) II alpha 170kDa -4.76475
HMGA2 high mobility group AT-hook 2 -4.54869
RPS4Y1 ribosomal protein S4, Y-linked 1 -4.54127
KLHDC2 kelch domain containing 2 -4.45413
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.24015
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -4.22091
MELK maternal embryonic leucine zipper kinase -4.19233
ZMIZ1 zinc finger, MIZ-type containing 1 -4.0572
GTPBP8 GTP-binding protein 8 (putative) -3.84283
ICAM3 intercellular adhesion molecule 3 -3.74961
CDK1 cyclin-dependent kinase 1 -3.7488
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.69146
HMOX1 heme oxygenase 1 -3.63099
THAP11 THAP domain containing 11 -3.59467
CD320 CD320 molecule -3.5323
AURKB aurora kinase B -3.51463
CHEK2 checkpoint kinase 2 -3.48114
FGFR4 fibroblast growth factor receptor 4 -3.40259
USP6NL USP6 N-terminal like -3.39196
HADH hydroxyacyl-CoA dehydrogenase -3.37528
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -3.31621
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.30599
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.30416
CCNB2 cyclin B2 -3.18952
STAT1 signal transducer and activator of transcription 1, 91kDa -3.05647
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.03787
COPS7A COP9 signalosome subunit 7A -2.96529
TCTN1 tectonic family member 1 -2.9457
PCCB propionyl CoA carboxylase, beta polypeptide -2.93926
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.87274
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.86544
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.85094
REEP5 receptor accessory protein 5 -2.83321
UBE2C ubiquitin-conjugating enzyme E2C -2.8035
ALG6 ALG6, alpha-1,3-glucosyltransferase -2.66204
CCS copper chaperone for superoxide dismutase -2.64359
AGMAT agmatine ureohydrolase (agmatinase) -2.61417
USP1 ubiquitin specific peptidase 1 -2.58078
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 -2.57452
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.53713
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.51423
INTS3 integrator complex subunit 3 -2.51203
EGF epidermal growth factor -2.49555
APOM apolipoprotein M -2.48618
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.46624
C2CD5 C2 calcium-dependent domain containing 5 -2.44639
MAT1A methionine adenosyltransferase I, alpha -2.44178
TBC1D10C TBC1 domain family, member 10C -2.4277
BRIX1 BRX1, biogenesis of ribosomes -2.42411
CDC25B cell division cycle 25B -2.41877
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.39922
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.3886
ALDOC aldolase C, fructose-bisphosphate -2.38243
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.36567
TMEM135 transmembrane protein 135 -2.34707
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.34194
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -2.33201
ETFB electron-transfer-flavoprotein, beta polypeptide -2.32912
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 -2.32346
PHGDH phosphoglycerate dehydrogenase -2.31508
GLDC glycine dehydrogenase (decarboxylating) -2.29952
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.29338
NUCB2 nucleobindin 2 -2.25994
COG2 component of oligomeric golgi complex 2 -2.25969
CDK6 cyclin-dependent kinase 6 -2.24432
MBL2 mannose-binding lectin (protein C) 2, soluble -2.24337
WASHC4 WASH complex subunit 4 -2.23424
CCNA2 cyclin A2 -2.22773
CLTC clathrin, heavy chain (Hc) -2.22389
BCAS3 breast carcinoma amplified sequence 3 -2.21074
TMEM267 transmembrane protein 267 -2.20604
CRTAP cartilage associated protein -2.19182
GALK1 galactokinase 1 -2.17397
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 -2.16544
DCP2 decapping mRNA 2 -2.15753
AMBP alpha-1-microglobulin/bikunin precursor -2.14524
ASGR1 asialoglycoprotein receptor 1 -2.1439
EAPP E2F-associated phosphoprotein -2.12841
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.11973
MBNL3 muscleblind-like splicing regulator 3 -2.10396
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.08518
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.06379
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.05434
TOMM70 translocase of outer mitochondrial membrane 70 -2.04745
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.03897
KHK ketohexokinase (fructokinase) -2.03682
FBXO5 F-box protein 5 -2.01975
ACOT2 acyl-CoA thioesterase 2 -2.01854
ANKRD10 ankyrin repeat domain 10 -2.0098
SCAND1 SCAN domain containing 1 -2.00711
ACBD4 acyl-CoA binding domain containing 4 -2.00149