CRCGN012_HEPG2_24H:M16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,2',5,5'-tetrachlorobenzidine 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

133 genes differentially expressed following the CRCGN012_HEPG2_24H:M16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 6.79438
UBQLN2 ubiquilin 2 6.10651
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.44898
H2BC12 H2B clustered histone 12 5.23242
GATA3 GATA binding protein 3 4.40749
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.06516
ZW10 zw10 kinetochore protein 4.058
ATP11B ATPase, class VI, type 11B 3.99928
NOTCH1 notch 1 3.94886
GRWD1 glutamate-rich WD repeat containing 1 3.89408
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.74949
CYCS cytochrome c, somatic 3.70548
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.63087
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.53969
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.48975
TESK1 testis-specific kinase 1 3.35913
ZNF589 zinc finger protein 589 3.35297
FOSL1 FOS-like antigen 1 3.32293
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.26882
ABHD6 abhydrolase domain containing 6 3.23667
TIMP2 TIMP metallopeptidase inhibitor 2 3.07765
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.07753
H2BC21 H2B clustered histone 21 2.93458
NMU neuromedin U 2.8942
STIMATE STIM activating enhancer 2.87007
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.7848
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 2.78324
GADD45A growth arrest and DNA-damage-inducible, alpha 2.77019
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.71408
RAB21 RAB21, member RAS oncogene family 2.66521
THAP11 THAP domain containing 11 2.59213
SMIM40 small integral membrane protein 40 2.57368
BAX BCL2-associated X protein 2.52847
PRKCD protein kinase C, delta 2.51384
NPDC1 neural proliferation, differentiation and control, 1 2.48253
CEP57 centrosomal protein 57kDa 2.46316
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.42473
PLK1 polo-like kinase 1 2.39288
EBNA1BP2 EBNA1 binding protein 2 2.35791
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.33119
CCDC51 coiled-coil domain containing 51 2.30358
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 2.26388
CHN1 chimerin 1 2.26078
CDC20 cell division cycle 20 2.20826
SETD1A SET domain containing 1A 2.20231
TERF2IP telomeric repeat binding factor 2, interacting protein 2.17932
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.16863
CCDC57 coiled-coil domain containing 57 2.15
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.1308
NFU1 NFU1 iron-sulfur cluster scaffold 2.12216
FAM234B family with sequence similarity 234 member B 2.12131
FAM53C family with sequence similarity 53, member C 2.10719
ELAC2 elaC ribonuclease Z 2 2.09596
PELI1 pellino E3 ubiquitin protein ligase 1 2.09324
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.08261
AGO1 argonaute RISC catalytic component 1 2.0661
FJX1 four jointed box 1 (Drosophila) 2.03925
PTDSS1 phosphatidylserine synthase 1 2.03503
CCP110 centriolar coiled coil protein 110kDa 2.01966

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -6.79607
MELK maternal embryonic leucine zipper kinase -5.58684
CDK1 cyclin-dependent kinase 1 -5.26008
UBE2C ubiquitin-conjugating enzyme E2C -5.03854
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.71497
TOP2A topoisomerase (DNA) II alpha 170kDa -4.39702
HMGA2 high mobility group AT-hook 2 -4.39595
TRIB3 tribbles pseudokinase 3 -4.10778
UGDH UDP-glucose 6-dehydrogenase -4.02352
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.02258
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.94245
PGM1 phosphoglucomutase 1 -3.86362
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.64096
CRELD2 cysteine-rich with EGF-like domains 2 -3.62066
RFC2 replication factor C (activator 1) 2, 40kDa -3.49152
ISOC1 isochorismatase domain containing 1 -3.44122
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.34852
PCNA proliferating cell nuclear antigen -3.31549
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.27898
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -3.18328
TCTN1 tectonic family member 1 -3.17232
NISCH nischarin -3.16374
DERA deoxyribose-phosphate aldolase (putative) -3.10967
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.92902
VAT1 vesicle amine transport 1 -2.81954
RGS2 regulator of G-protein signaling 2 -2.74521
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) -2.73926
STAT1 signal transducer and activator of transcription 1, 91kDa -2.73886
USP6NL USP6 N-terminal like -2.70593
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.60145
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.56482
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.5555
FGFR4 fibroblast growth factor receptor 4 -2.55358
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.52189
GNAS GNAS complex locus -2.51135
NFIL3 nuclear factor, interleukin 3 regulated -2.49314
ALDOC aldolase C, fructose-bisphosphate -2.4758
DDIT4 DNA-damage-inducible transcript 4 -2.45591
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.44593
ICAM3 intercellular adhesion molecule 3 -2.43424
SLC35F2 solute carrier family 35, member F2 -2.43308
WASHC4 WASH complex subunit 4 -2.38316
USP1 ubiquitin specific peptidase 1 -2.38263
NNT nicotinamide nucleotide transhydrogenase -2.37151
EAPP E2F-associated phosphoprotein -2.3581
NAGK N-acetylglucosamine kinase -2.32858
GALE UDP-galactose-4-epimerase -2.2895
UBE3C ubiquitin protein ligase E3C -2.27646
MAPK13 mitogen-activated protein kinase 13 -2.27535
AMDHD2 amidohydrolase domain containing 2 -2.25996
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.23243
PDS5A PDS5 cohesin associated factor A -2.2323
TMEM97 transmembrane protein 97 -2.22621
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.22189
NRIP1 nuclear receptor interacting protein 1 -2.18765
CHEK2 checkpoint kinase 2 -2.17593
HEATR1 HEAT repeat containing 1 -2.16639
LOC124907782 dual specificity protein phosphatase 22 -2.16631
AKAP11 A kinase (PRKA) anchor protein 11 -2.16494
BEAN1 brain expressed, associated with NEDD4, 1 -2.16465
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.14528
CDK4 cyclin-dependent kinase 4 -2.13101
PECR peroxisomal trans-2-enoyl-CoA reductase -2.12235
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.11367
FBXL12 F-box and leucine-rich repeat protein 12 -2.10352
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.09484
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -2.08332
PHF11 PHD finger protein 11 -2.07587
CLTC clathrin, heavy chain (Hc) -2.07512
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.07187
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.05451
HMOX1 heme oxygenase 1 -2.02123
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.00724
FBXO7 F-box protein 7 -2.00663