CRCGN012_HEPG2_24H:M18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,2',5,5'-tetrachlorobenzidine 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN012_HEPG2_24H:M18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PNKP polynucleotide kinase 3'-phosphatase 5.67365
NOSIP nitric oxide synthase interacting protein 4.57664
LAGE3 L antigen family, member 3 4.53661
E2F2 E2F transcription factor 2 4.32081
CIAO3 cytosolic iron-sulfur assembly component 3 4.07742
STIMATE STIM activating enhancer 4.06211
PPARG peroxisome proliferator-activated receptor gamma 4.04199
NOTCH1 notch 1 4.01622
AMDHD2 amidohydrolase domain containing 2 4.0011
UBQLN2 ubiquilin 2 3.96874
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.9682
ATP11B ATPase, class VI, type 11B 3.80883
TIAM1 T-cell lymphoma invasion and metastasis 1 3.6214
LYN LYN proto-oncogene, Src family tyrosine kinase 3.41771
ABHD6 abhydrolase domain containing 6 3.08008
LCN2 lipocalin 2 3.06556
EPN2 epsin 2 3.00297
IDE insulin-degrading enzyme 2.4796
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.46468
SATB1 SATB homeobox 1 2.45432
RB1 retinoblastoma 1 2.40512
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.38151
H2BC12 H2B clustered histone 12 2.34728
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.34634
TBXA2R thromboxane A2 receptor 2.18734
CEP57 centrosomal protein 57kDa 2.02802

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -5.91761
ADI1 acireductone dioxygenase 1 -5.61066
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.32485
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.27121
KDM3A lysine (K)-specific demethylase 3A -4.25101
GDF15 growth differentiation factor 15 -4.06929
VAT1 vesicle amine transport 1 -4.01244
SLC35F2 solute carrier family 35, member F2 -3.84282
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.77051
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.65759
PDHX pyruvate dehydrogenase complex, component X -3.50127
MAPK13 mitogen-activated protein kinase 13 -3.20015
MTA1 metastasis associated 1 -2.62772
DSG2 desmoglein 2 -2.60398
TLCD3A TLC domain containing 3A -2.59606
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.42885
ZMIZ1 zinc finger, MIZ-type containing 1 -2.27747
STMN1 stathmin 1 -2.25377
CD58 CD58 molecule -2.21352
HLA-DMA major histocompatibility complex, class II, DM alpha -2.10651
OXA1L oxidase (cytochrome c) assembly 1-like -2.07233
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.04628
CDC20 cell division cycle 20 -2.00189