| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | pregnenolone 21.26 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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67 genes differentially expressed following the CRCGN012_HEPG2_24H:M19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMIM40 | small integral membrane protein 40 | 5.956 |
| CHMP6 | charged multivesicular body protein 6 | 5.72567 |
| GSTZ1 | glutathione S-transferase zeta 1 | 5.24732 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 4.37567 |
| STIMATE | STIM activating enhancer | 3.6645 |
| LCN2 | lipocalin 2 | 3.53453 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 3.53036 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 3.48979 |
| JADE2 | jade family PHD finger 2 | 3.44265 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | 3.29324 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 3.17727 |
| NOTCH1 | notch 1 | 3.14793 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.11035 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 3.00406 |
| GPATCH8 | G patch domain containing 8 | 3.00021 |
| MYLK | myosin light chain kinase | 2.68744 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.65653 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.56531 |
| ABHD4 | abhydrolase domain containing 4 | 2.53038 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 2.47267 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 2.46837 |
| PMM2 | phosphomannomutase 2 | 2.43153 |
| WDTC1 | WD and tetratricopeptide repeats 1 | 2.35998 |
| KDM5A | lysine (K)-specific demethylase 5A | 2.34701 |
| PRODH | proline dehydrogenase (oxidase) 1 | 2.28364 |
| MAP7 | microtubule-associated protein 7 | 2.21667 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 2.20104 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.17127 |
| ECD | ecdysoneless homolog (Drosophila) | 2.16053 |
| UGDH | UDP-glucose 6-dehydrogenase | 2.14351 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 2.10865 |
| KCNK5 | potassium channel, two pore domain subfamily K, member 5 | 2.08593 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.06336 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 2.06093 |
| SQSTM1 | sequestosome 1 | 2.05468 |
| FEM1C | fem-1 homolog c (C. elegans) | 2.00015 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDC20 | cell division cycle 20 | -7.30534 |
| LDHD | lactate dehydrogenase D | -6.33181 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -6.15933 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -6.08728 |
| GNAS | GNAS complex locus | -5.27558 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -4.26835 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -4.12093 |
| MRPS16 | mitochondrial ribosomal protein S16 | -3.45276 |
| CCDC86 | coiled-coil domain containing 86 | -3.28737 |
| DNM1L | dynamin 1-like | -3.26955 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -3.04648 |
| ADI1 | acireductone dioxygenase 1 | -3.04485 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | -3.00178 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.85322 |
| CCNB1 | cyclin B1 | -2.81964 |
| SLC35F2 | solute carrier family 35, member F2 | -2.78291 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -2.7504 |
| HEATR1 | HEAT repeat containing 1 | -2.72629 |
| CCNB2 | cyclin B2 | -2.50949 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.48648 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.42591 |
| PDHX | pyruvate dehydrogenase complex, component X | -2.37355 |
| AURKA | aurora kinase A | -2.30448 |
| LEP | leptin | -2.25496 |
| CHMP4B | charged multivesicular body protein 4B | -2.24564 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -2.23616 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -2.19636 |
| TIMM10 | translocase of inner mitochondrial membrane 10 homolog (yeast) | -2.07759 |
| TES | testin LIM domain protein | -2.05224 |
| PCNA | proliferating cell nuclear antigen | -2.0257 |
| NAT10 | N-acetyltransferase 10 (GCN5-related) | -2.01057 |
