| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | pregnenolone 0.66 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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61 genes differentially expressed following the CRCGN012_HEPG2_24H:M24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PPARG | peroxisome proliferator-activated receptor gamma | 5.76714 |
| HOXA10 | homeobox A10 | 4.72391 |
| PRR15L | proline rich 15-like | 4.04913 |
| CCNF | cyclin F | 3.50248 |
| LCN2 | lipocalin 2 | 3.46127 |
| STK10 | serine/threonine kinase 10 | 3.33704 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | 3.07637 |
| AMDHD2 | amidohydrolase domain containing 2 | 2.90323 |
| CSK | c-src tyrosine kinase | 2.76522 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 2.74623 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.7386 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 2.68655 |
| E2F2 | E2F transcription factor 2 | 2.64834 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 2.56003 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.55096 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.48516 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 2.48284 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 2.40425 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 2.39026 |
| SUPV3L1 | suppressor of var1, 3-like 1 (S. cerevisiae) | 2.38099 |
| ABHD6 | abhydrolase domain containing 6 | 2.37944 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.36246 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 2.35812 |
| SKIC2 | SKI2 subunit of superkiller complex | 2.21968 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) | 2.1816 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | 2.1512 |
| HEBP1 | heme binding protein 1 | 2.09278 |
| MTREX | Mtr4 exosome RNA helicase | 2.06905 |
| AAR2 | AAR2 splicing factor homolog (S. cerevisiae) | 2.05389 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.04979 |
| PIH1D1 | PIH1 domain containing 1 | 2.04728 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 2.00257 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -6.03852 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -4.45129 |
| ISOC1 | isochorismatase domain containing 1 | -3.9575 |
| TLCD3A | TLC domain containing 3A | -3.81865 |
| KDM3A | lysine (K)-specific demethylase 3A | -3.81801 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.64856 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -3.54373 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.50669 |
| CCNB1 | cyclin B1 | -3.42869 |
| VDAC1 | voltage-dependent anion channel 1 | -3.30549 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -3.29582 |
| COG2 | component of oligomeric golgi complex 2 | -3.19569 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -3.18221 |
| MTA1 | metastasis associated 1 | -3.14728 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -3.05982 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -3.04276 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.03716 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -2.99849 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | -2.67522 |
| MAP7 | microtubule-associated protein 7 | -2.66272 |
| ZW10 | zw10 kinetochore protein | -2.58421 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.40344 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -2.33662 |
| URGCP | upregulator of cell proliferation | -2.22833 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -2.1994 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.17057 |
| PRPF4 | pre-mRNA processing factor 4 | -2.15436 |
| SNX11 | sorting nexin 11 | -2.15398 |
| HMG20B | high mobility group 20B | -2.02023 |
