CRCGN012_HEPG2_24H:N02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dibromoethane 19.6 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN012_HEPG2_24H:N02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYLK myosin light chain kinase 9.7526
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 8.10634
PPARG peroxisome proliferator-activated receptor gamma 5.91217
E2F2 E2F transcription factor 2 5.58253
CBR3 carbonyl reductase 3 5.04985
BACE2 beta-site APP-cleaving enzyme 2 4.90641
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.74553
ANO1 anoctamin 1, calcium activated chloride channel 4.67684
EPHA3 EPH receptor A3 4.55674
KLHL21 kelch-like family member 21 4.33901
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.67883
HOXA10 homeobox A10 3.58503
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.53707
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.29622
STXBP2 syntaxin binding protein 2 3.05082
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.04891
PEX11A peroxisomal biogenesis factor 11 alpha 3.04087
SNAP25 synaptosomal-associated protein, 25kDa 2.98794
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.8598
TIAM1 T-cell lymphoma invasion and metastasis 1 2.63698
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.60151
ABHD6 abhydrolase domain containing 6 2.58012
GATA3 GATA binding protein 3 2.51981
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.41842
SEMG2 semenogelin II 2.37371
TRMT9B tRNA methyltransferase 9B (putative) 2.34885
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.34116
PYGB phosphorylase, glycogen; brain 2.26158
DNASE2B deoxyribonuclease II beta 2.26076
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 2.24146
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 2.1202
ACKR2 atypical chemokine receptor 2 2.11203
CXCL2 chemokine (C-X-C motif) ligand 2 2.04151
JADE2 jade family PHD finger 2 2.03619
CCL7 chemokine (C-C motif) ligand 7 2.03378
SEMG1 semenogelin I 2.00922

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -4.50519
GTPBP8 GTP-binding protein 8 (putative) -3.93583
CCNB2 cyclin B2 -3.79165
FBXL12 F-box and leucine-rich repeat protein 12 -3.35052
GNAS GNAS complex locus -2.99884
OXA1L oxidase (cytochrome c) assembly 1-like -2.92916
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.84143
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.8285
SNX11 sorting nexin 11 -2.78235
SCAND1 SCAN domain containing 1 -2.64025
TCTN1 tectonic family member 1 -2.5101
FBXO7 F-box protein 7 -2.30694
TM9SF3 transmembrane 9 superfamily member 3 -2.27316
RAI14 retinoic acid induced 14 -2.09415
CHPF chondroitin polymerizing factor -2.07959
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.02829
MRPS2 mitochondrial ribosomal protein S2 -2.00819