CRCGN012_HEPG2_24H:N03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dibromoethane 9.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN012_HEPG2_24H:N03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 7.22858
ADRB2 adrenoceptor beta 2, surface 3.79356
DYNLT3 dynein, light chain, Tctex-type 3 3.28781
CSK c-src tyrosine kinase 3.27317
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.25809
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.19799
EPN2 epsin 2 3.19226
PRR15L proline rich 15-like 3.11225
ADGRE5 adhesion G protein-coupled receptor E5 2.9924
AMDHD2 amidohydrolase domain containing 2 2.9009
PPARG peroxisome proliferator-activated receptor gamma 2.88831
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.83928
CEP57 centrosomal protein 57kDa 2.73948
ABHD4 abhydrolase domain containing 4 2.73565
PLS1 plastin 1 2.6747
ABHD6 abhydrolase domain containing 6 2.59022
TBXA2R thromboxane A2 receptor 2.54259
SFTPB surfactant protein B 2.52529
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.42518
ATL2 atlastin GTPase 2 2.02762
LPAR2 lysophosphatidic acid receptor 2 2.00475

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.83829
ADI1 acireductone dioxygenase 1 -4.23382
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.83001
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.6739
PRPF4 pre-mRNA processing factor 4 -3.59392
KDM3A lysine (K)-specific demethylase 3A -3.58096
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.43802
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.36739
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.31056
MAPK13 mitogen-activated protein kinase 13 -3.24044
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.02539
CCNB2 cyclin B2 -3.01035
RPN1 ribophorin I -2.97705
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.80459
LOC124907782 dual specificity protein phosphatase 22 -2.79221
C2CD5 C2 calcium-dependent domain containing 5 -2.71183
LDHD lactate dehydrogenase D -2.5736
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.40329
FGFR4 fibroblast growth factor receptor 4 -2.26174
FBXO7 F-box protein 7 -2.18435
TM9SF3 transmembrane 9 superfamily member 3 -2.10785
MVP major vault protein -2.02878