CRCGN012_HEPG2_24H:N05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dibromoethane 2.45 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN012_HEPG2_24H:N05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 6.51377
LCN2 lipocalin 2 4.17786
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.16032
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.9551
TIAM1 T-cell lymphoma invasion and metastasis 1 3.93801
GPATCH8 G patch domain containing 8 3.47504
CHMP6 charged multivesicular body protein 6 3.38615
LPAR2 lysophosphatidic acid receptor 2 3.29367
FCHO1 FCH domain only 1 3.26219
RRAGA Ras-related GTP binding A 3.14695
ALDOC aldolase C, fructose-bisphosphate 2.835
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.59761
ANO1 anoctamin 1, calcium activated chloride channel 2.55571
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.48678
GPER1 G protein-coupled estrogen receptor 1 2.46316
ARID4B AT rich interactive domain 4B (RBP1-like) 2.29751
CCL2 chemokine (C-C motif) ligand 2 2.23417
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.15729
SOCS2 suppressor of cytokine signaling 2 2.15683
BLMH bleomycin hydrolase 2.08531
MIDEAS mitotic deacetylase associated SANT domain protein 2.08448
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.06201
PLS1 plastin 1 2.0529
MEST mesoderm specific transcript 2.05014

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -7.7157
ARID5B AT rich interactive domain 5B (MRF1-like) -4.73107
UGDH UDP-glucose 6-dehydrogenase -4.21219
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.13268
OXA1L oxidase (cytochrome c) assembly 1-like -3.96172
ZMIZ1 zinc finger, MIZ-type containing 1 -3.90014
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.87867
GNAS GNAS complex locus -3.3424
NGRN neugrin, neurite outgrowth associated -3.28368
RFC2 replication factor C (activator 1) 2, 40kDa -3.24122
DUSP6 dual specificity phosphatase 6 -2.7208
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.71146
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.70563
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.63376
DERA deoxyribose-phosphate aldolase (putative) -2.44649
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.3795
RPL36A ribosomal protein L36a -2.34715
PTPRK protein tyrosine phosphatase, receptor type, K -2.25338
TRAPPC6A trafficking protein particle complex 6A -2.22524
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.06518
TES testin LIM domain protein -2.01412
RNF167 ring finger protein 167 -2.01048