CRCGN012_HEPG2_24H:N13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description aroclor 1016 38.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN012_HEPG2_24H:N13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 8.42616
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 5.99316
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 5.38941
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.06418
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.85994
NOSIP nitric oxide synthase interacting protein 3.77453
GATA3 GATA binding protein 3 3.5484
TIAM1 T-cell lymphoma invasion and metastasis 1 3.11884
MEST mesoderm specific transcript 3.08791
GPER1 G protein-coupled estrogen receptor 1 3.0172
GRWD1 glutamate-rich WD repeat containing 1 2.90092
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.88212
ADGRG1 adhesion G protein-coupled receptor G1 2.61483
CARMIL1 capping protein regulator and myosin 1 linker 1 2.36349
ABHD4 abhydrolase domain containing 4 2.23422
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.13549
CEP57 centrosomal protein 57kDa 2.09815
ATAD2 ATPase family, AAA domain containing 2 2.08813
PMM2 phosphomannomutase 2 2.04912

decreased expression

Symbol Name Standardized Value
TRIB3 tribbles pseudokinase 3 -10.0
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -6.20747
CAB39 calcium binding protein 39 -5.30812
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.99397
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.98994
NT5DC2 5'-nucleotidase domain containing 2 -4.90515
LAP3 leucine aminopeptidase 3 -4.71813
MRPS2 mitochondrial ribosomal protein S2 -4.4388
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.91054
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.7537
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.59592
THAP11 THAP domain containing 11 -3.57477
FAIM Fas apoptotic inhibitory molecule -3.56329
TSPAN4 tetraspanin 4 -3.54058
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.4942
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.14536
CDC20 cell division cycle 20 -3.00679
VAT1 vesicle amine transport 1 -2.82094
MACF1 microtubule-actin crosslinking factor 1 -2.82091
CCNB1 cyclin B1 -2.81679
TGM3 transglutaminase 3 -2.45492
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.44799
SLC39A2 solute carrier family 39 (zinc transporter), member 2 -2.26709
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.22532
LINC02762 long intergenic non-protein coding RNA 2762 -2.17583
SLURP1 secreted LY6/PLAUR domain containing 1 -2.17031
GDF15 growth differentiation factor 15 -2.08315
RGS2 regulator of G-protein signaling 2 -2.06546
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.04851
S100A9 S100 calcium binding protein A9 -2.0148
LBR lamin B receptor -2.0086
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -2.00804