| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | curcumin 10.32 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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58 genes differentially expressed following the CRCGN012_HEPG2_24H:N20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 6.88986 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 4.21793 |
| GPER1 | G protein-coupled estrogen receptor 1 | 4.15218 |
| E2F2 | E2F transcription factor 2 | 4.08145 |
| UBQLN2 | ubiquilin 2 | 3.97056 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 3.60879 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.55261 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 3.30816 |
| PPARG | peroxisome proliferator-activated receptor gamma | 3.09994 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.03309 |
| PRR15L | proline rich 15-like | 2.98007 |
| UGDH | UDP-glucose 6-dehydrogenase | 2.94035 |
| KLHL9 | kelch-like family member 9 | 2.85876 |
| LCN2 | lipocalin 2 | 2.77714 |
| TXNRD1 | thioredoxin reductase 1 | 2.70008 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 2.67093 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.62918 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 2.43227 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 2.42337 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.40967 |
| CIDEC | cell death-inducing DFFA-like effector c | 2.25387 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 2.13786 |
| TBC1D10C | TBC1 domain family, member 10C | 2.04293 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | 2.03892 |
| CCNA1 | cyclin A1 | 2.03046 |
| H2BC12 | H2B clustered histone 12 | 2.01504 |
| SQSTM1 | sequestosome 1 | 2.00583 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -9.58794 |
| ADI1 | acireductone dioxygenase 1 | -6.01091 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -5.43678 |
| MAPK13 | mitogen-activated protein kinase 13 | -4.16968 |
| HMG20B | high mobility group 20B | -3.61075 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.51561 |
| CCNB2 | cyclin B2 | -3.45475 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -3.43116 |
| ZNF586 | zinc finger protein 586 | -3.42242 |
| TRIB3 | tribbles pseudokinase 3 | -3.22372 |
| LDHD | lactate dehydrogenase D | -3.15328 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -3.15304 |
| CCNB1 | cyclin B1 | -3.09426 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.07899 |
| VDAC1 | voltage-dependent anion channel 1 | -2.88994 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.81447 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.79125 |
| GDF15 | growth differentiation factor 15 | -2.59714 |
| DDIT4 | DNA-damage-inducible transcript 4 | -2.52045 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -2.49127 |
| PLK1 | polo-like kinase 1 | -2.48425 |
| RHEB | Ras homolog enriched in brain | -2.29322 |
| TLCD3A | TLC domain containing 3A | -2.26858 |
| CD58 | CD58 molecule | -2.26633 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -2.1965 |
| SOAT2 | sterol O-acyltransferase 2 | -2.18294 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -2.12921 |
| S100A4 | S100 calcium binding protein A4 | -2.12267 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -2.11599 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.05675 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -2.05524 |
