CRCGN012_HEPG2_24H:O08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description hydrochlorothiazide 19.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN012_HEPG2_24H:O08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF589 zinc finger protein 589 5.55375
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 4.8984
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.26992
UBQLN2 ubiquilin 2 3.8921
CHN1 chimerin 1 3.79958
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.78155
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.68817
SOCS2 suppressor of cytokine signaling 2 3.60721
PNKP polynucleotide kinase 3'-phosphatase 3.50073
CCL2 chemokine (C-C motif) ligand 2 3.47051
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.44523
MYLK myosin light chain kinase 3.35467
EPHA3 EPH receptor A3 3.25037
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.24994
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.15051
CIAO3 cytosolic iron-sulfur assembly component 3 3.01781
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.00714
SNAP25 synaptosomal-associated protein, 25kDa 2.9695
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.85418
HSPA1A heat shock 70kDa protein 1A 2.74374
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.56747
PRR15L proline rich 15-like 2.5101
NOTCH1 notch 1 2.47895
TLR4 toll-like receptor 4 2.45564
AMDHD2 amidohydrolase domain containing 2 2.45469
GPER1 G protein-coupled estrogen receptor 1 2.43584
WDTC1 WD and tetratricopeptide repeats 1 2.31458
JADE2 jade family PHD finger 2 2.31124
DDR2 discoidin domain receptor tyrosine kinase 2 2.26676
MOK MOK protein kinase 2.23928
BMX BMX non-receptor tyrosine kinase 2.23854
PRRX1 paired related homeobox 1 2.21272
PMM2 phosphomannomutase 2 2.18936
NLRP2 NLR family, pyrin domain containing 2 2.1668
E2F2 E2F transcription factor 2 2.16634
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.10444
CNN3 calponin 3, acidic 2.07304
IRF2 interferon regulatory factor 2 2.03615

decreased expression

Symbol Name Standardized Value
CASP7 caspase 7, apoptosis-related cysteine peptidase -6.51831
MRPS2 mitochondrial ribosomal protein S2 -5.96715
GOLT1B golgi transport 1B -4.78446
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.06674
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.05512
KDM3A lysine (K)-specific demethylase 3A -4.01853
CDC20 cell division cycle 20 -3.58498
ADI1 acireductone dioxygenase 1 -3.46534
OXA1L oxidase (cytochrome c) assembly 1-like -3.26355
EIF5 eukaryotic translation initiation factor 5 -3.11719
NT5DC2 5'-nucleotidase domain containing 2 -3.05835
GNAS GNAS complex locus -2.98213
HLA-DMA major histocompatibility complex, class II, DM alpha -2.69744
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.62173
FBXL12 F-box and leucine-rich repeat protein 12 -2.51314
TLCD3A TLC domain containing 3A -2.40981
CCNB1 cyclin B1 -2.37867
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.30642
ITGB1BP1 integrin beta 1 binding protein 1 -2.2602
MKRN2 makorin ring finger protein 2 -2.24858
TM9SF3 transmembrane 9 superfamily member 3 -2.14306
SEC13 SEC13 homolog (S. cerevisiae) -2.09558
ACOT9 acyl-CoA thioesterase 9 -2.02646
NUP85 nucleoporin 85kDa -2.01928