| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | hydrochlorothiazide 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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63 genes differentially expressed following the CRCGN012_HEPG2_24H:O12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ANO1 | anoctamin 1, calcium activated chloride channel | 4.43637 |
| H2BC12 | H2B clustered histone 12 | 4.41574 |
| NOSIP | nitric oxide synthase interacting protein | 4.3496 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.28719 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 4.18904 |
| CYCS | cytochrome c, somatic | 4.14817 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 3.83369 |
| PRR15L | proline rich 15-like | 3.54533 |
| RAB21 | RAB21, member RAS oncogene family | 3.46719 |
| NOTCH1 | notch 1 | 3.22409 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.19105 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.13187 |
| CCNF | cyclin F | 3.11612 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 3.07015 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.85553 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.75702 |
| PTK2 | protein tyrosine kinase 2 | 2.7418 |
| CHN1 | chimerin 1 | 2.70056 |
| PNKP | polynucleotide kinase 3'-phosphatase | 2.59642 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.57886 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.54061 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 2.48153 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.44552 |
| CCL2 | chemokine (C-C motif) ligand 2 | 2.39758 |
| HEBP1 | heme binding protein 1 | 2.36218 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.3449 |
| TLR4 | toll-like receptor 4 | 2.26369 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 2.20545 |
| MEST | mesoderm specific transcript | 2.17441 |
| PPARG | peroxisome proliferator-activated receptor gamma | 2.13545 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | 2.13321 |
| MRPL48 | mitochondrial ribosomal protein L48 | 2.06933 |
| JAG2 | jagged 2 | 2.03415 |
| HYOU1 | hypoxia up-regulated 1 | 2.01727 |
| NIT1 | nitrilase 1 | 2.00036 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB2 | cyclin B2 | -5.44692 |
| LDHD | lactate dehydrogenase D | -5.35716 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.17944 |
| UGDH | UDP-glucose 6-dehydrogenase | -4.71524 |
| GNAS | GNAS complex locus | -4.6052 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -4.55453 |
| ADI1 | acireductone dioxygenase 1 | -4.41192 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -4.31993 |
| PLK1 | polo-like kinase 1 | -3.80977 |
| EGF | epidermal growth factor | -3.40373 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -3.37999 |
| EIF5 | eukaryotic translation initiation factor 5 | -3.33997 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.31051 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -2.96108 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.92592 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.61897 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -2.61631 |
| PEG10 | paternally expressed 10 | -2.53909 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.36716 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.354 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -2.32982 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.24477 |
| MRPS2 | mitochondrial ribosomal protein S2 | -2.1787 |
| DDIT4 | DNA-damage-inducible transcript 4 | -2.12656 |
| ZNF586 | zinc finger protein 586 | -2.11877 |
| WASHC4 | WASH complex subunit 4 | -2.08914 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | -2.04768 |
| FNDC4 | fibronectin type III domain containing 4 | -2.04123 |
