CRCGN012_HEPG2_24H:O13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclopentanone oxime 41.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN012_HEPG2_24H:O13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.71771
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.51867
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.5057
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.1226
E2F2 E2F transcription factor 2 3.09563
ADRB2 adrenoceptor beta 2, surface 3.0949
CSK c-src tyrosine kinase 3.00793
CHMP6 charged multivesicular body protein 6 3.0071
NOTCH1 notch 1 2.9507
CIAO3 cytosolic iron-sulfur assembly component 3 2.90123
MCOLN1 mucolipin 1 2.87457
CCNF cyclin F 2.8064
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.7937
CBR1 carbonyl reductase 1 2.68177
PMM2 phosphomannomutase 2 2.66863
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.62497
ATP11B ATPase, class VI, type 11B 2.52417
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.48687
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.3552
LCN2 lipocalin 2 2.30487
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.02803

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -6.51743
PCNA proliferating cell nuclear antigen -5.41557
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.6253
RFC2 replication factor C (activator 1) 2, 40kDa -3.75758
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.74227
ZMIZ1 zinc finger, MIZ-type containing 1 -3.70177
DNM1L dynamin 1-like -3.56657
ZNF586 zinc finger protein 586 -3.55057
TP53BP2 tumor protein p53 binding protein 2 -3.5176
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.39723
CCDC86 coiled-coil domain containing 86 -3.3752
MVP major vault protein -3.3421
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.30025
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.28857
EGF epidermal growth factor -3.17313
ADI1 acireductone dioxygenase 1 -3.1172
CDC20 cell division cycle 20 -3.11227
GDF15 growth differentiation factor 15 -3.09727
DERA deoxyribose-phosphate aldolase (putative) -3.07873
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.06327
CCNB2 cyclin B2 -2.97723
PLK1 polo-like kinase 1 -2.90117
COG7 component of oligomeric golgi complex 7 -2.88557
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.8698
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.82217
GNAS GNAS complex locus -2.61784
TLCD3A TLC domain containing 3A -2.55563
OXA1L oxidase (cytochrome c) assembly 1-like -2.52183
ITGB1BP1 integrin beta 1 binding protein 1 -2.34428
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.33797
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.3224
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.30235
MAP7 microtubule-associated protein 7 -2.30088
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.23087
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.15263
PEG10 paternally expressed 10 -2.07115
RGS2 regulator of G-protein signaling 2 -2.0423
WHRN whirlin -2.03772