CRCGN012_HEPG2_24H:O15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclopentanone oxime 10.3 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

63 genes differentially expressed following the CRCGN012_HEPG2_24H:O15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PEX11A peroxisomal biogenesis factor 11 alpha 6.8606
PPARG peroxisome proliferator-activated receptor gamma 5.42016
MYLK myosin light chain kinase 5.18795
MINDY1 MINDY lysine 48 deubiquitinase 1 4.51113
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.33437
GSTZ1 glutathione S-transferase zeta 1 4.29815
STK10 serine/threonine kinase 10 4.00408
GPER1 G protein-coupled estrogen receptor 1 3.99593
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.7933
CHMP6 charged multivesicular body protein 6 3.77587
RPL39L ribosomal protein L39-like 3.75969
LOC122526780 uncharacterized LOC122526780 3.5219
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.29402
LYN LYN proto-oncogene, Src family tyrosine kinase 3.15749
SOCS2 suppressor of cytokine signaling 2 3.00586
ADAM10 ADAM metallopeptidase domain 10 2.98384
ZNF589 zinc finger protein 589 2.78925
PTK2 protein tyrosine kinase 2 2.77305
DIPK1A divergent protein kinase domain 1A 2.72604
NPDC1 neural proliferation, differentiation and control, 1 2.63489
KIF5C kinesin family member 5C 2.47231
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.45813
NEK2 NIMA-related kinase 2 2.26738
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.23529
HOOK2 hook microtubule-tethering protein 2 2.22887
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.2213
NIT1 nitrilase 1 2.18123
INTS13 integrator complex subunit 13 2.14011
CHEK2 checkpoint kinase 2 2.11952
ZNF232 zinc finger protein 232 2.11805
PRPF39 pre-mRNA processing factor 39 2.06519
HSPA1A heat shock 70kDa protein 1A 2.04647
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.04023
ZMYM2 zinc finger, MYM-type 2 2.02881
EVL Enah/Vasp-like 2.02268
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 2.01097

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -7.33873
CCNB2 cyclin B2 -7.00308
LDHD lactate dehydrogenase D -5.83858
PECR peroxisomal trans-2-enoyl-CoA reductase -5.24306
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.22159
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -5.20843
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.97735
EGF epidermal growth factor -4.4716
WASHC4 WASH complex subunit 4 -4.29135
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.9007
MAPK13 mitogen-activated protein kinase 13 -3.78381
GTPBP8 GTP-binding protein 8 (putative) -3.64536
SNX11 sorting nexin 11 -3.50856
RPIA ribose 5-phosphate isomerase A -3.3693
GNAS GNAS complex locus -3.2831
ADI1 acireductone dioxygenase 1 -3.20228
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.19602
EIF5 eukaryotic translation initiation factor 5 -2.85694
GDF15 growth differentiation factor 15 -2.83906
CD58 CD58 molecule -2.83781
ICAM3 intercellular adhesion molecule 3 -2.56129
FBXL12 F-box and leucine-rich repeat protein 12 -2.44752
SH3GL1 SH3-domain GRB2-like 1 -2.13189
S100A12 S100 calcium binding protein A12 -2.12117
PRDM4 PR domain containing 4 -2.09861
FBRS fibrosin -2.046
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.02603