CRCGN012_HEPG2_24H:O17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyclopentanone oxime 2.57 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

85 genes differentially expressed following the CRCGN012_HEPG2_24H:O17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 7.06315
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.15323
AMDHD2 amidohydrolase domain containing 2 4.8228
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.66727
BACE2 beta-site APP-cleaving enzyme 2 4.48334
STIMATE STIM activating enhancer 3.93533
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.17718
CYCS cytochrome c, somatic 3.10795
LPAR2 lysophosphatidic acid receptor 2 3.03346
SIRT3 sirtuin 3 2.99748
TLR4 toll-like receptor 4 2.77268
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.75395
EVL Enah/Vasp-like 2.73394
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.66929
C2CD2 C2 calcium-dependent domain containing 2 2.66702
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.56713
PCDHA2 protocadherin alpha 2 2.49844
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.49238
PRR15L proline rich 15-like 2.39544
DPF3 D4, zinc and double PHD fingers, family 3 2.35771
CHRM5 cholinergic receptor, muscarinic 5 2.34814
E2F2 E2F transcription factor 2 2.31929
EBLN2 endogenous Bornavirus-like nucleoprotein 2 2.30745
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.27406
TAS2R16 taste receptor, type 2, member 16 2.25316
FSTL4 follistatin-like 4 2.2269
PNKP polynucleotide kinase 3'-phosphatase 2.21602
TEX13A testis expressed 13A 2.21599
CTSL cathepsin L 2.21379
CD101 CD101 molecule 2.20009
GSTCD glutathione S-transferase, C-terminal domain containing 2.19179
VGLL4 vestigial-like family member 4 2.18891
G6PC2 glucose-6-phosphatase, catalytic, 2 2.18538
ACTN3 actinin, alpha 3 (gene/pseudogene) 2.18493
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.17498
SIGLEC9 sialic acid binding Ig-like lectin 9 2.17008
OR12D3 olfactory receptor, family 12, subfamily D, member 3 2.15129
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 2.12989
HOXD12 homeobox D12 2.10629
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.10552
OR1G1 olfactory receptor, family 1, subfamily G, member 1 2.10085
PCDHB1 protocadherin beta 1 2.09839
ZNF549 zinc finger protein 549 2.09447
PHKG1 phosphorylase kinase, gamma 1 (muscle) 2.08469
PLSCR1 phospholipid scramblase 1 2.08403
KRTAP2-3 keratin associated protein 2-3 2.08065
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa 2.07418
LGALS12 lectin, galactoside-binding, soluble, 12 2.06795
ZNF613 zinc finger protein 613 2.06602
ADRB1 adrenoceptor beta 1 2.06199
CFAP46 cilia and flagella associated protein 46 2.061
CLUL1 clusterin-like 1 (retinal) 2.05307
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.04627
PAX7 paired box 7 2.03629
FSD1 fibronectin type III and SPRY domain containing 1 2.03305
GUCY2F guanylate cyclase 2F, retinal 2.033
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.03208
MTNR1A melatonin receptor 1A 2.02742
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.02659
PSG11 pregnancy specific beta-1-glycoprotein 11 2.02481
OTUD7B OTU deubiquitinase 7B 2.02474
SLC66A3 solute carrier family 66 member 3 2.02396
DCHS2 dachsous cadherin-related 2 2.01866
TPD52L2 tumor protein D52-like 2 2.01384
LATS1 large tumor suppressor kinase 1 2.01369
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.01045
BMP15 bone morphogenetic protein 15 2.00673
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.00061

decreased expression

Symbol Name Standardized Value
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -7.03815
LDHD lactate dehydrogenase D -6.94702
CCNB2 cyclin B2 -6.30734
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.18881
VAT1 vesicle amine transport 1 -5.0208
UBE3C ubiquitin protein ligase E3C -4.93301
TLCD3A TLC domain containing 3A -4.61432
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -4.17487
TM9SF3 transmembrane 9 superfamily member 3 -3.52298
RFC2 replication factor C (activator 1) 2, 40kDa -3.50901
KDM3A lysine (K)-specific demethylase 3A -3.37987
MAPK13 mitogen-activated protein kinase 13 -2.52209
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.2151
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.20365
CLIP2 CAP-GLY domain containing linker protein 2 -2.1515
GPSM2 G-protein signaling modulator 2 -2.0754
USP6NL USP6 N-terminal like -2.00596