CRCGN012_HEPG2_24H:O20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-amino-2,4-dibromoanthraquinone 12.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN012_HEPG2_24H:O20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 7.33863
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.79215
GPER1 G protein-coupled estrogen receptor 1 5.98451
ABHD4 abhydrolase domain containing 4 4.60452
ATP11B ATPase, class VI, type 11B 4.05342
STIMATE STIM activating enhancer 3.8955
DYNLT3 dynein, light chain, Tctex-type 3 3.74627
CHN1 chimerin 1 3.44068
RPP38 ribonuclease P/MRP 38kDa subunit 3.18991
CCL2 chemokine (C-C motif) ligand 2 3.08778
STK10 serine/threonine kinase 10 3.0374
E2F2 E2F transcription factor 2 3.02736
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.96577
NFIL3 nuclear factor, interleukin 3 regulated 2.93692
NPDC1 neural proliferation, differentiation and control, 1 2.79286
CREG1 cellular repressor of E1A-stimulated genes 1 2.69681
STAP2 signal transducing adaptor family member 2 2.63864
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.54578
HSPA1A heat shock 70kDa protein 1A 2.52092
TXNRD1 thioredoxin reductase 1 2.51887
CBR3 carbonyl reductase 3 2.4645
TESK1 testis-specific kinase 1 2.37261
HEXB hexosaminidase B (beta polypeptide) 2.17213
ECM1 extracellular matrix protein 1 2.09792
MEST mesoderm specific transcript 2.05234

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.19532
ZNF586 zinc finger protein 586 -7.44811
LDHD lactate dehydrogenase D -6.52128
MRPS2 mitochondrial ribosomal protein S2 -5.58059
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.39035
LOC124907782 dual specificity protein phosphatase 22 -4.06326
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.03967
DNM1L dynamin 1-like -4.00768
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.67693
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.41081
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.40071
RFC2 replication factor C (activator 1) 2, 40kDa -3.07186
ADI1 acireductone dioxygenase 1 -3.03173
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.02795
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.94062
MAPK13 mitogen-activated protein kinase 13 -2.93638
PDLIM1 PDZ and LIM domain 1 -2.68641
ICAM3 intercellular adhesion molecule 3 -2.66114
C2CD5 C2 calcium-dependent domain containing 5 -2.6322
CXCL2 chemokine (C-X-C motif) ligand 2 -2.5937
HEATR1 HEAT repeat containing 1 -2.58289
PSRC1 proline/serine-rich coiled-coil 1 -2.50864
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.50011
ZNF134 zinc finger protein 134 -2.49883
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.45581
NRIP1 nuclear receptor interacting protein 1 -2.36361
ZNF551 zinc finger protein 551 -2.26738
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.18436
KIFAP3 kinesin-associated protein 3 -2.14461
LGMN legumain -2.11622
PMPCA peptidase (mitochondrial processing) alpha -2.04154
ZNF304 zinc finger protein 304 -2.03318