CRCGN012_HEPG2_24H:O23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-amino-2,4-dibromoanthraquinone 1.56 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN012_HEPG2_24H:O23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADRB2 adrenoceptor beta 2, surface 8.59823
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 8.39047
NOTCH1 notch 1 5.4323
MAMLD1 mastermind-like domain containing 1 4.74399
CARMIL1 capping protein regulator and myosin 1 linker 1 4.66767
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.62446
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.89826
MSRA methionine sulfoxide reductase A 3.77462
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.49666
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.48764
ATP11B ATPase, class VI, type 11B 3.23686
HSPA1A heat shock 70kDa protein 1A 3.07873
NOSIP nitric oxide synthase interacting protein 3.00807
ABHD6 abhydrolase domain containing 6 2.94261
E2F2 E2F transcription factor 2 2.8289
PLS1 plastin 1 2.68322
LCN2 lipocalin 2 2.58529
NVL nuclear VCP-like 2.51066
FPGS folylpolyglutamate synthase 2.49174
PMM2 phosphomannomutase 2 2.34786
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.28513
SAA2 serum amyloid A2 2.17272
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.11653
CCNH cyclin H 2.11648
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.05839
ACTN2 actinin, alpha 2 2.04988
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.03428
GYG2 glycogenin 2 2.01433
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.00887

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.02016
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.24545
LDHD lactate dehydrogenase D -4.95737
MAP7 microtubule-associated protein 7 -4.57814
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.44611
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.13857
PRPF4 pre-mRNA processing factor 4 -3.56133
SNX11 sorting nexin 11 -3.44168
FBXL12 F-box and leucine-rich repeat protein 12 -3.30544
DDIT4 DNA-damage-inducible transcript 4 -2.85151
SSBP2 single-stranded DNA binding protein 2 -2.82987
WASHC4 WASH complex subunit 4 -2.81411
MAPK13 mitogen-activated protein kinase 13 -2.68783
TM9SF3 transmembrane 9 superfamily member 3 -2.62514
FAT1 FAT atypical cadherin 1 -2.43289
PCNA proliferating cell nuclear antigen -2.08927