| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 3,3',5,5'-tetrabromobisphenol a 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
| Downloads & Tools |
80 genes differentially expressed following the CRCGN012_HEPG2_24H:P01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PPARG | peroxisome proliferator-activated receptor gamma | 6.81488 |
| CSK | c-src tyrosine kinase | 6.39834 |
| GPATCH8 | G patch domain containing 8 | 4.13181 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.07174 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 4.01617 |
| ABHD4 | abhydrolase domain containing 4 | 3.92395 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 3.80389 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.63772 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 3.59263 |
| UGDH | UDP-glucose 6-dehydrogenase | 3.50534 |
| MYLK | myosin light chain kinase | 3.43902 |
| UBQLN2 | ubiquilin 2 | 3.37278 |
| GPER1 | G protein-coupled estrogen receptor 1 | 3.24017 |
| PRR15L | proline rich 15-like | 3.23079 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 2.8419 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.81012 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.80235 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.79125 |
| TXNRD1 | thioredoxin reductase 1 | 2.76594 |
| MVP | major vault protein | 2.74196 |
| NOSIP | nitric oxide synthase interacting protein | 2.72784 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 2.71046 |
| TRIB3 | tribbles pseudokinase 3 | 2.69156 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.63823 |
| E2F2 | E2F transcription factor 2 | 2.62328 |
| NOTCH1 | notch 1 | 2.57268 |
| PLSCR3 | phospholipid scramblase 3 | 2.43578 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.43257 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 2.3569 |
| STX4 | syntaxin 4 | 2.31272 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.24508 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 2.23907 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.22095 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.16414 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | 2.16342 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 2.09222 |
| ZFP36 | ZFP36 ring finger protein | 2.06535 |
| INPP1 | inositol polyphosphate-1-phosphatase | 2.06255 |
| IMPDH1 | IMP (inosine 5'-monophosphate) dehydrogenase 1 | 2.0618 |
| LSR | lipolysis stimulated lipoprotein receptor | 2.0369 |
| PPFIBP2 | PTPRF interacting protein, binding protein 2 (liprin beta 2) | 2.03366 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ADI1 | acireductone dioxygenase 1 | -7.09914 |
| TCTN1 | tectonic family member 1 | -6.68598 |
| CCNB2 | cyclin B2 | -5.81469 |
| GNAS | GNAS complex locus | -5.44419 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -4.40062 |
| EGF | epidermal growth factor | -4.06604 |
| AURKB | aurora kinase B | -3.94673 |
| NGRN | neugrin, neurite outgrowth associated | -3.94341 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -3.88158 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.4431 |
| CDC20 | cell division cycle 20 | -3.311 |
| PLK1 | polo-like kinase 1 | -3.19612 |
| PCNA | proliferating cell nuclear antigen | -3.12726 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.00633 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.7732 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -2.77037 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | -2.67761 |
| MELK | maternal embryonic leucine zipper kinase | -2.60033 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.53327 |
| HAT1 | histone acetyltransferase 1 | -2.49511 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -2.46983 |
| ISOC1 | isochorismatase domain containing 1 | -2.41718 |
| LBR | lamin B receptor | -2.39282 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.36153 |
| TCERG1 | transcription elongation regulator 1 | -2.3566 |
| COPS7A | COP9 signalosome subunit 7A | -2.34599 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.32605 |
| MYL9 | myosin, light chain 9, regulatory | -2.30949 |
| RPS5 | ribosomal protein S5 | -2.27903 |
| FBXL12 | F-box and leucine-rich repeat protein 12 | -2.25129 |
| GLRB | glycine receptor, beta | -2.2416 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -2.21611 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.19105 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -2.1256 |
| MLF1 | myeloid leukemia factor 1 | -2.09712 |
| LOC112694756 | uncharaterized LOC112694756 | -2.08215 |
| SMC4 | structural maintenance of chromosomes 4 | -2.055 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -2.00495 |
| FBXO5 | F-box protein 5 | -2.00065 |
