| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 3,3',5,5'-tetrabromobisphenol a 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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127 genes differentially expressed following the CRCGN012_HEPG2_24H:P03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AMDHD2 | amidohydrolase domain containing 2 | 6.24508 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.2367 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 4.74908 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 4.73559 |
| STIMATE | STIM activating enhancer | 4.60872 |
| PLS1 | plastin 1 | 4.58397 |
| CSK | c-src tyrosine kinase | 4.31816 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 4.30897 |
| PRR15L | proline rich 15-like | 4.28872 |
| CTSL | cathepsin L | 3.93734 |
| KDM5A | lysine (K)-specific demethylase 5A | 3.54983 |
| SOCS2 | suppressor of cytokine signaling 2 | 3.49643 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | 3.36139 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 3.26689 |
| TBC1D31 | TBC1 domain family, member 31 | 3.26265 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | 3.255 |
| DIPK1A | divergent protein kinase domain 1A | 3.18302 |
| NNT | nicotinamide nucleotide transhydrogenase | 3.1065 |
| MKNK1 | MAP kinase interacting serine/threonine kinase 1 | 2.98126 |
| TENT4A | terminal nucleotidyltransferase 4A | 2.82753 |
| CCDC86 | coiled-coil domain containing 86 | 2.80344 |
| CREB1 | cAMP responsive element binding protein 1 | 2.75138 |
| JADE2 | jade family PHD finger 2 | 2.71005 |
| EVL | Enah/Vasp-like | 2.60045 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 2.56588 |
| PCNA | proliferating cell nuclear antigen | 2.49166 |
| ABCF1 | ATP-binding cassette, sub-family F (GCN20), member 1 | 2.38119 |
| COG2 | component of oligomeric golgi complex 2 | 2.33656 |
| ICE1 | interactor of little elongation complex ELL subunit 1 | 2.32517 |
| PEPD | peptidase D | 2.32046 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 2.29735 |
| GSTA4 | glutathione S-transferase alpha 4 | 2.25589 |
| PFKL | phosphofructokinase, liver | 2.25279 |
| SMAD3 | SMAD family member 3 | 2.23237 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 2.21887 |
| ANKRD10 | ankyrin repeat domain 10 | 2.1686 |
| FOXO3 | forkhead box O3 | 2.15944 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 2.14217 |
| CYCS | cytochrome c, somatic | 2.13914 |
| HMG20B | high mobility group 20B | 2.12166 |
| LOC122526780 | uncharacterized LOC122526780 | 2.11653 |
| CDK7 | cyclin-dependent kinase 7 | 2.10519 |
| BLCAP | bladder cancer associated protein | 2.09794 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 2.08087 |
| CHERP | calcium homeostasis endoplasmic reticulum protein | 2.07134 |
| DUSP14 | dual specificity phosphatase 14 | 2.07089 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 2.06162 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 2.03465 |
| STK38 | serine/threonine kinase 38 | 2.03262 |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta | 2.03163 |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | 2.0292 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 2.02842 |
| MBNL2 | muscleblind-like splicing regulator 2 | 2.02306 |
| HSPA2 | heat shock 70kDa protein 2 | 2.01892 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 2.01243 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 2.00676 |
| RNF43 | ring finger protein 43 | 2.00058 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC35F2 | solute carrier family 35, member F2 | -7.35731 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.44143 |
| NGRN | neugrin, neurite outgrowth associated | -5.18139 |
| ZNF586 | zinc finger protein 586 | -5.09171 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -4.94327 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | -4.46634 |
| LDHD | lactate dehydrogenase D | -4.44617 |
| ZW10 | zw10 kinetochore protein | -4.23673 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | -4.14733 |
| HAT1 | histone acetyltransferase 1 | -4.05002 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -3.99044 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | -3.79911 |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -3.71752 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | -3.51603 |
| TCTN1 | tectonic family member 1 | -3.51548 |
| SNX11 | sorting nexin 11 | -3.16261 |
| EAPP | E2F-associated phosphoprotein | -3.14874 |
| ENOPH1 | enolase-phosphatase 1 | -3.12922 |
| SCAND1 | SCAN domain containing 1 | -2.92606 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | -2.91853 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.90927 |
| EI24 | etoposide induced 2.4 | -2.88796 |
| CRYZ | crystallin, zeta (quinone reductase) | -2.86313 |
| PSMG1 | proteasome (prosome, macropain) assembly chaperone 1 | -2.81422 |
| ILK | integrin-linked kinase | -2.7579 |
| CHEK1 | checkpoint kinase 1 | -2.75399 |
| ACAA1 | acetyl-CoA acyltransferase 1 | -2.74065 |
| NUP93 | nucleoporin 93kDa | -2.70425 |
| LRRC41 | leucine rich repeat containing 41 | -2.6332 |
| PSME1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | -2.51804 |
| PPY | pancreatic polypeptide | -2.49087 |
| CAB39 | calcium binding protein 39 | -2.47171 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -2.45079 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -2.44193 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -2.42382 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -2.39337 |
| RGS2 | regulator of G-protein signaling 2 | -2.38822 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -2.3801 |
| DDIT4 | DNA-damage-inducible transcript 4 | -2.36493 |
| IPO13 | importin 13 | -2.35094 |
| UBE4A | ubiquitination factor E4A | -2.33901 |
| TBPL1 | TBP-like 1 | -2.32393 |
| MRPS16 | mitochondrial ribosomal protein S16 | -2.31704 |
| MMRN2 | multimerin 2 | -2.31586 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -2.30863 |
| THYN1 | thymocyte nuclear protein 1 | -2.28341 |
| RASL11B | RAS-like, family 11, member B | -2.23641 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.23036 |
| CHIT1 | chitinase 1 (chitotriosidase) | -2.21756 |
| USP22 | ubiquitin specific peptidase 22 | -2.21545 |
| SNX19 | sorting nexin 19 | -2.20025 |
| S100A13 | S100 calcium binding protein A13 | -2.16968 |
| ARCN1 | archain 1 | -2.16849 |
| SYN1 | synapsin I | -2.16531 |
| EPM2AIP1 | EPM2A (laforin) interacting protein 1 | -2.15915 |
| FAIM | Fas apoptotic inhibitory molecule | -2.15477 |
| EBNA1BP2 | EBNA1 binding protein 2 | -2.15098 |
| RHOG | ras homolog family member G | -2.14558 |
| ANXA7 | annexin A7 | -2.13447 |
| PRRG1 | proline rich Gla (G-carboxyglutamic acid) 1 | -2.11451 |
| SDHB | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | -2.11192 |
| GLOD4 | glyoxalase domain containing 4 | -2.11064 |
| NFU1 | NFU1 iron-sulfur cluster scaffold | -2.10815 |
| CDK4 | cyclin-dependent kinase 4 | -2.09664 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | -2.04746 |
| CAVIN3 | caveolae associated protein 3 | -2.02832 |
| DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial | -2.01703 |
| SCN3B | sodium channel, voltage gated, type III beta subunit | -2.01455 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | -2.01206 |
| LY75-CD302 | LY75-CD302 readthrough | -2.00619 |
