CRCGN012_HEPG2_24H:P04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3',5,5'-tetrabromobisphenol a 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN012_HEPG2_24H:P04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CSK c-src tyrosine kinase 5.45353
STAP2 signal transducing adaptor family member 2 2.9219
VAV3 vav 3 guanine nucleotide exchange factor 2.69074
CISD1 CDGSH iron sulfur domain 1 2.60133
LOC122526780 uncharacterized LOC122526780 2.58937
TEX10 testis expressed 10 2.53951
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.51429
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.50729
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.49635
PLSCR3 phospholipid scramblase 3 2.39627
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.30844
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.15329
ZNF318 zinc finger protein 318 2.14376
HOXA10 homeobox A10 2.14049
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.13679
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.11117
BLMH bleomycin hydrolase 2.10837
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.10389
TLR4 toll-like receptor 4 2.0939
CCL2 chemokine (C-C motif) ligand 2 2.02589

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.45687
GNAS GNAS complex locus -4.73178
TSEN2 TSEN2 tRNA splicing endonuclease subunit -4.37274
UGDH UDP-glucose 6-dehydrogenase -3.69967
HSPB1 heat shock 27kDa protein 1 -3.61814
FBXL12 F-box and leucine-rich repeat protein 12 -3.58735
ITGB1BP1 integrin beta 1 binding protein 1 -3.50534
LOC124907782 dual specificity protein phosphatase 22 -3.11141
PCNA proliferating cell nuclear antigen -3.09625
CD320 CD320 molecule -2.91205
NT5DC2 5'-nucleotidase domain containing 2 -2.87894
LDHD lactate dehydrogenase D -2.86414
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.80725
REEP5 receptor accessory protein 5 -2.78773
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.65794
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.62856
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.62088
RFC2 replication factor C (activator 1) 2, 40kDa -2.38181
ZW10 zw10 kinetochore protein -2.37929
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.34967