CRCGN012_HEPG2_24H:P06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3',5,5'-tetrabromobisphenol a 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN012_HEPG2_24H:P06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
JADE2 jade family PHD finger 2 4.48271
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 4.40445
STIMATE STIM activating enhancer 4.22091
NOTCH1 notch 1 3.78351
EPHB2 EPH receptor B2 3.5003
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.38332
ADRB2 adrenoceptor beta 2, surface 3.25262
CSK c-src tyrosine kinase 3.14218
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.13251
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.11511
MYLK myosin light chain kinase 3.04028
MOK MOK protein kinase 2.92937
E2F2 E2F transcription factor 2 2.91415
CGRRF1 cell growth regulator with ring finger domain 1 2.85546
STK10 serine/threonine kinase 10 2.84496
RAB21 RAB21, member RAS oncogene family 2.73295
CDK6 cyclin-dependent kinase 6 2.62885
ADGRE5 adhesion G protein-coupled receptor E5 2.61552
UBQLN2 ubiquilin 2 2.56552
HEBP1 heme binding protein 1 2.5572
LOC122526780 uncharacterized LOC122526780 2.546
EPN2 epsin 2 2.5018
PRKCH protein kinase C, eta 2.26451
GSTZ1 glutathione S-transferase zeta 1 2.17175
VGLL4 vestigial-like family member 4 2.13251
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.10094

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -6.94092
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -6.6593
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -6.61655
TARBP1 TAR (HIV-1) RNA binding protein 1 -6.04432
TRIB3 tribbles pseudokinase 3 -3.70424
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.61692
EGF epidermal growth factor -3.5937
RPS5 ribosomal protein S5 -3.44281
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.30367
ZNF586 zinc finger protein 586 -3.26
PCNA proliferating cell nuclear antigen -3.21798
ADI1 acireductone dioxygenase 1 -3.21145
GDF15 growth differentiation factor 15 -3.1639
TRAPPC3 trafficking protein particle complex 3 -2.67241
CCDC86 coiled-coil domain containing 86 -2.6629
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.55211
MAPK13 mitogen-activated protein kinase 13 -2.3341
CCNB2 cyclin B2 -2.07844
RHEB Ras homolog enriched in brain -2.00753