CRCGN012_HEPG2_24H:P07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(1-naphthyl)ethylenediamine.2hcl 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

300 genes differentially expressed following the CRCGN012_HEPG2_24H:P07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 7.05468
UBE2L6 ubiquitin-conjugating enzyme E2L 6 6.5219
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 6.18921
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 6.11561
NSDHL NAD(P) dependent steroid dehydrogenase-like 5.12833
TIMP2 TIMP metallopeptidase inhibitor 2 5.08663
ATP11B ATPase, class VI, type 11B 4.95663
CIAO3 cytosolic iron-sulfur assembly component 3 4.94838
ELOVL6 ELOVL fatty acid elongase 6 4.71204
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 4.67338
TRIB3 tribbles pseudokinase 3 4.51421
ALDOC aldolase C, fructose-bisphosphate 4.46479
ECH1 enoyl CoA hydratase 1, peroxisomal 4.43909
STAP2 signal transducing adaptor family member 2 4.38074
UBQLN2 ubiquilin 2 4.37674
TENT4A terminal nucleotidyltransferase 4A 4.29696
MTERF3 mitochondrial transcription termination factor 3 4.21096
SOAT2 sterol O-acyltransferase 2 4.03589
STXBP1 syntaxin binding protein 1 3.96722
VAT1 vesicle amine transport 1 3.91452
LOC122526780 uncharacterized LOC122526780 3.89826
TCTN1 tectonic family member 1 3.84396
SFTPB surfactant protein B 3.82378
MVP major vault protein 3.75685
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.7005
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 3.69864
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.62696
ALAS1 5'-aminolevulinate synthase 1 3.57639
WDR7 WD repeat domain 7 3.57052
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 3.54638
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.473
FDFT1 farnesyl-diphosphate farnesyltransferase 1 3.46117
IPO13 importin 13 3.44833
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 3.44673
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.41374
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 3.3831
MYLK myosin light chain kinase 3.35273
ZNF589 zinc finger protein 589 3.34343
H2BC12 H2B clustered histone 12 3.30339
CHEK2 checkpoint kinase 2 3.30293
VAV3 vav 3 guanine nucleotide exchange factor 3.25949
E2F2 E2F transcription factor 2 3.24539
PLP2 proteolipid protein 2 (colonic epithelium-enriched) 3.21671
STIMATE STIM activating enhancer 3.19708
RAP1GAP RAP1 GTPase activating protein 3.15457
WFS1 Wolfram syndrome 1 (wolframin) 3.11229
CDC45 cell division cycle 45 3.08064
MEST mesoderm specific transcript 3.06727
SNX7 sorting nexin 7 3.0373
PPARG peroxisome proliferator-activated receptor gamma 2.99026
SQSTM1 sequestosome 1 2.9738
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.94481
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 2.9386
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.92582
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.8788
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.87699
TXNRD1 thioredoxin reductase 1 2.87009
KIAA0930 KIAA0930 2.82119
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.81432
H2BC21 H2B clustered histone 21 2.78968
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 2.75866
PTK2 protein tyrosine kinase 2 2.754
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.73227
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 2.73
MMP2 matrix metallopeptidase 2 2.71309
STX4 syntaxin 4 2.71291
ZFP36 ZFP36 ring finger protein 2.66783
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.65464
TMEM97 transmembrane protein 97 2.65175
SCD stearoyl-CoA desaturase (delta-9-desaturase) 2.60891
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.60366
CHN1 chimerin 1 2.57623
CHMP6 charged multivesicular body protein 6 2.57014
TRIM2 tripartite motif containing 2 2.5254
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 2.51382
UGDH UDP-glucose 6-dehydrogenase 2.48102
MAP7 microtubule-associated protein 7 2.47592
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.47321
GPER1 G protein-coupled estrogen receptor 1 2.44391
AMACR alpha-methylacyl-CoA racemase 2.44029
LPAR2 lysophosphatidic acid receptor 2 2.40372
EPN3 epsin 3 2.362
NLGN4Y neuroligin 4, Y-linked 2.34088
KCTD5 potassium channel tetramerization domain containing 5 2.3389
EED embryonic ectoderm development 2.31703
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.31251
NVL nuclear VCP-like 2.2949
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.28536
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.28532
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 2.26336
CARMIL1 capping protein regulator and myosin 1 linker 1 2.25401
CREG1 cellular repressor of E1A-stimulated genes 1 2.25382
TMEM109 transmembrane protein 109 2.25346
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.2379
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 2.23698
ETFB electron-transfer-flavoprotein, beta polypeptide 2.23497
GADD45A growth arrest and DNA-damage-inducible, alpha 2.22244
PRELP proline/arginine-rich end leucine-rich repeat protein 2.21527
CCDC92 coiled-coil domain containing 92 2.2086
TPSG1 tryptase gamma 1 2.17281
PGRMC1 progesterone receptor membrane component 1 2.16855
STX3 syntaxin 3 2.16747
ADGRG1 adhesion G protein-coupled receptor G1 2.15877
PHGDH phosphoglycerate dehydrogenase 2.15738
FZD1 frizzled class receptor 1 2.15677
MMP27 matrix metallopeptidase 27 2.15501
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.15372
MTM1 myotubularin 1 2.15191
KLHDC2 kelch domain containing 2 2.14467
TLR4 toll-like receptor 4 2.14058
TRAPPC6A trafficking protein particle complex 6A 2.13268
CEP72 centrosomal protein 72kDa 2.12891
SMIM40 small integral membrane protein 40 2.10497
PSG2 pregnancy specific beta-1-glycoprotein 2 2.09896
FILIP1L filamin A interacting protein 1-like 2.0977
TEX10 testis expressed 10 2.08185
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.07704
MINDY1 MINDY lysine 48 deubiquitinase 1 2.06501
LMBR1 limb development membrane protein 1 2.05919
HMOX1 heme oxygenase 1 2.05529
PLA2G2F phospholipase A2, group IIF 2.05092
PYGB phosphorylase, glycogen; brain 2.05027
ADAM15 ADAM metallopeptidase domain 15 2.0485
NIT1 nitrilase 1 2.04094
FGFR2 fibroblast growth factor receptor 2 2.0339
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 2.0311
PRDM14 PR domain containing 14 2.02948
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.02842
AMDHD2 amidohydrolase domain containing 2 2.022
SREBF2 sterol regulatory element binding transcription factor 2 2.02138
APOL3 apolipoprotein L, 3 2.02082
SQLE squalene epoxidase 2.01902
TEX2 testis expressed 2 2.01738
LRRC31 leucine rich repeat containing 31 2.0106
GRK3 G protein-coupled receptor kinase 3 2.00895
TECPR2 tectonin beta-propeller repeat containing 2 2.00859
CRYBG1 crystallin beta-gamma domain containing 1 2.00674
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.00532
ANXA4 annexin A4 2.00216
HTRA1 HtrA serine peptidase 1 2.00102
DCLK1 doublecortin-like kinase 1 2.00052
RRAGC Ras-related GTP binding C 2.0004

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -10.0
CDC20 cell division cycle 20 -7.14396
ZNF586 zinc finger protein 586 -6.93159
PLK1 polo-like kinase 1 -6.52553
IER3 immediate early response 3 -5.7827
ZDHHC6 zinc finger, DHHC-type containing 6 -5.09262
GOLT1B golgi transport 1B -5.04494
KDM3A lysine (K)-specific demethylase 3A -4.98496
CDK1 cyclin-dependent kinase 1 -4.88985
PGAM4 phosphoglycerate mutase family member 4 -4.60939
FASTKD5 FAST kinase domains 5 -4.57851
DNM1L dynamin 1-like -4.53993
PCCB propionyl CoA carboxylase, beta polypeptide -4.45797
MELK maternal embryonic leucine zipper kinase -4.41615
PSRC1 proline/serine-rich coiled-coil 1 -4.04669
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.92241
MRPS16 mitochondrial ribosomal protein S16 -3.86873
CD320 CD320 molecule -3.86391
GTF2A2 general transcription factor IIA, 2, 12kDa -3.85442
TCERG1 transcription elongation regulator 1 -3.82462
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.66309
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.61834
TOP2A topoisomerase (DNA) II alpha 170kDa -3.55615
PYCR1 pyrroline-5-carboxylate reductase 1 -3.53181
SLC35B1 solute carrier family 35, member B1 -3.52631
RNASE7 ribonuclease, RNase A family, 7 -3.40524
HAT1 histone acetyltransferase 1 -3.393
ADI1 acireductone dioxygenase 1 -3.39204
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.37193
UBE2C ubiquitin-conjugating enzyme E2C -3.30126
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.24232
CCNA2 cyclin A2 -3.21288
ISOC1 isochorismatase domain containing 1 -3.14371
BIRC5 baculoviral IAP repeat containing 5 -3.1178
DPH2 DPH2 homolog (S. cerevisiae) -3.0949
USP6NL USP6 N-terminal like -3.06976
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.05151
NCAPD2 non-SMC condensin I complex, subunit D2 -3.00532
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.98656
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.96482
ZNF134 zinc finger protein 134 -2.95503
MYCBP MYC binding protein -2.94026
NUP85 nucleoporin 85kDa -2.87997
S100A9 S100 calcium binding protein A9 -2.85971
COPS7A COP9 signalosome subunit 7A -2.85021
MED21 mediator complex subunit 21 -2.84025
MRPS22 mitochondrial ribosomal protein S22 -2.83553
SBNO1 strawberry notch homolog 1 (Drosophila) -2.80352
RNPS1 RNA binding protein S1, serine-rich domain -2.79292
STMN1 stathmin 1 -2.78824
LAGE3 L antigen family, member 3 -2.77194
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.76517
LOC128031832 uncharacterized LOC128031832 -2.72106
NLRP2B NLR family pyrin domain containing 2B -2.72054
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.6992
RPS5 ribosomal protein S5 -2.66061
RPS12 ribosomal protein S12 -2.62083
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.61999
SMC4 structural maintenance of chromosomes 4 -2.61842
AURKA aurora kinase A -2.58837
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.56167
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.54456
PRPF4 pre-mRNA processing factor 4 -2.53812
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.53524
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.52238
MRPL42 mitochondrial ribosomal protein L42 -2.51087
UBE2S ubiquitin-conjugating enzyme E2S -2.46794
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -2.45857
BIRC2 baculoviral IAP repeat containing 2 -2.42732
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.42241
CCNB2 cyclin B2 -2.41254
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.39802
SNIP1 Smad nuclear interacting protein 1 -2.36826
ATP5MF ATP synthase membrane subunit f -2.35927
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -2.34625
CAB39 calcium binding protein 39 -2.34584
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.33958
AURKB aurora kinase B -2.33021
CCT4 chaperonin containing TCP1, subunit 4 (delta) -2.3209
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.31375
FGFR4 fibroblast growth factor receptor 4 -2.31253
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.31141
ANAPC15 anaphase promoting complex subunit 15 -2.30095
RPL39 ribosomal protein L39 -2.29304
ZMIZ1 zinc finger, MIZ-type containing 1 -2.2905
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.27737
RPL21 ribosomal protein L21 -2.27377
IL6 interleukin 6 -2.27103
OXA1L oxidase (cytochrome c) assembly 1-like -2.26838
RPIA ribose 5-phosphate isomerase A -2.26762
LIN7A lin-7 homolog A (C. elegans) -2.25899
SNX11 sorting nexin 11 -2.2569
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.25632
CCNB1 cyclin B1 -2.2497
HLA-DMA major histocompatibility complex, class II, DM alpha -2.23665
CASC3 cancer susceptibility candidate 3 -2.23147
MPHOSPH9 M-phase phosphoprotein 9 -2.22844
RPL23A ribosomal protein L23a -2.22557
GTPBP8 GTP-binding protein 8 (putative) -2.22008
KIF14 kinesin family member 14 -2.21556
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.21536
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -2.21194
LBR lamin B receptor -2.21096
RPS6 ribosomal protein S6 -2.20334
PGK1 phosphoglycerate kinase 1 -2.20265
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -2.19964
SF1 splicing factor 1 -2.19757
RPL41 ribosomal protein L41 -2.19406
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.19378
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.19369
LOC112694756 uncharaterized LOC112694756 -2.19014
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.18795
PFAS phosphoribosylformylglycinamidine synthase -2.17917
EAPP E2F-associated phosphoprotein -2.16611
TUBB6 tubulin, beta 6 class V -2.15883
MKRN2 makorin ring finger protein 2 -2.14983
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -2.1439
PRR7 proline rich 7 (synaptic) -2.13236
RPS23 ribosomal protein S23 -2.12693
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.11811
COMMD1 copper metabolism (Murr1) domain containing 1 -2.11226
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -2.11181
EXOSC9 exosome component 9 -2.10994
GLOD4 glyoxalase domain containing 4 -2.10615
CGGBP1 CGG triplet repeat binding protein 1 -2.10557
TM9SF3 transmembrane 9 superfamily member 3 -2.10211
RPS17 ribosomal protein S17 -2.09908
RPS18 ribosomal protein S18 -2.09713
DCP1A decapping mRNA 1A -2.09649
MCTS1 malignant T cell amplified sequence 1 -2.09272
RPS15 ribosomal protein S15 -2.08151
SELENOT selenoprotein T -2.07742
EGF epidermal growth factor -2.07623
RPS3A ribosomal protein S3A -2.07365
SPDL1 spindle apparatus coiled-coil protein 1 -2.07304
NFIL3 nuclear factor, interleukin 3 regulated -2.07186
RPL32 ribosomal protein L32 -2.06262
CCNF cyclin F -2.06181
PCNA proliferating cell nuclear antigen -2.04322
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.04071
POLR2G polymerase (RNA) II (DNA directed) polypeptide G -2.03725
NTAQ1 N-terminal glutamine amidase 1 -2.02942
EBNA1BP2 EBNA1 binding protein 2 -2.02925
MRPL48 mitochondrial ribosomal protein L48 -2.0279
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -2.02759
PPP4R3B protein phosphatase 4 regulatory subunit 3B -2.02749
ZNF274 zinc finger protein 274 -2.02413
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.02306
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.02217
ACOT9 acyl-CoA thioesterase 9 -2.02125
MRPL12 mitochondrial ribosomal protein L12 -2.01639
SRSF3 serine/arginine-rich splicing factor 3 -2.0159
ALG11 ALG11, alpha-1,2-mannosyltransferase -2.01581
NMD3 NMD3 ribosome export adaptor -2.01197
BUD31 BUD31 homolog (S. cerevisiae) -2.00685
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -2.00562
GMPPA GDP-mannose pyrophosphorylase A -2.00406
CENPA centromere protein A -2.00362