CRCGN012_HEPG2_24H:P08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(1-naphthyl)ethylenediamine.2hcl 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN012_HEPG2_24H:P08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 6.45063
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 6.34487
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.32522
MYLK myosin light chain kinase 3.98372
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.89998
ANO1 anoctamin 1, calcium activated chloride channel 3.62852
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.49413
ALDOC aldolase C, fructose-bisphosphate 3.41829
PRR15L proline rich 15-like 3.36173
EPHB2 EPH receptor B2 3.23381
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.0987
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.06607
MOK MOK protein kinase 3.05132
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.98293
CSK c-src tyrosine kinase 2.88613
CYCS cytochrome c, somatic 2.77947
MICALL1 MICAL-like 1 2.77497
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.7322
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.72433
BZW2 basic leucine zipper and W2 domains 2 2.57224
GATA3 GATA binding protein 3 2.42791
ELOVL6 ELOVL fatty acid elongase 6 2.38684
TCTN1 tectonic family member 1 2.38537
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 2.35504
MTERF3 mitochondrial transcription termination factor 3 2.34976
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.32286
ATP11B ATPase, class VI, type 11B 2.3125
SOAT2 sterol O-acyltransferase 2 2.28622
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.19569
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.16689
BAX BCL2-associated X protein 2.08079
SLC25A46 solute carrier family 25, member 46 2.07179
SQOR sulfide quinone oxidoreductase 2.06032
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.05736
OSBPL9 oxysterol binding protein-like 9 2.03155
NOSIP nitric oxide synthase interacting protein 2.02895

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -8.09535
VAT1 vesicle amine transport 1 -5.98483
PGAM4 phosphoglycerate mutase family member 4 -4.43537
KDM3A lysine (K)-specific demethylase 3A -4.21088
SLC35F2 solute carrier family 35, member F2 -4.15542
TUBB6 tubulin, beta 6 class V -4.04128
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.70389
HMG20B high mobility group 20B -3.52488
DNM1L dynamin 1-like -3.43501
IER3 immediate early response 3 -3.38568
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.38143
ADI1 acireductone dioxygenase 1 -3.032
PECR peroxisomal trans-2-enoyl-CoA reductase -2.92394
MAPK13 mitogen-activated protein kinase 13 -2.85262
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.82915
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.80572
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.6141
ZW10 zw10 kinetochore protein -2.46471
GNAS GNAS complex locus -2.36048
PRPF4 pre-mRNA processing factor 4 -2.34232
OXA1L oxidase (cytochrome c) assembly 1-like -2.32916
CLTA clathrin, light chain A -2.24838
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.18573
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.10769
RPP30 ribonuclease P/MRP 30kDa subunit -2.03354