CRCGN012_HEPG2_24H:P16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description erythrosine 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN012_HEPG2_24H:P16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRR15L proline rich 15-like 4.1584
TIMP2 TIMP metallopeptidase inhibitor 2 4.03432
RPP38 ribonuclease P/MRP 38kDa subunit 3.98089
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 3.87176
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.85938
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.63396
CCL2 chemokine (C-C motif) ligand 2 3.39546
CHMP6 charged multivesicular body protein 6 3.08203
NPDC1 neural proliferation, differentiation and control, 1 3.00874
LPAR2 lysophosphatidic acid receptor 2 2.53859
KDM5A lysine (K)-specific demethylase 5A 2.53676
HSPA1A heat shock 70kDa protein 1A 2.31328
TIAM1 T-cell lymphoma invasion and metastasis 1 2.25048
GTPBP6 GTP binding protein 6 (putative) 2.1874
CHN1 chimerin 1 2.119
LOC122526780 uncharacterized LOC122526780 2.11534

decreased expression

Symbol Name Standardized Value
NGRN neugrin, neurite outgrowth associated -5.97357
CD320 CD320 molecule -4.50076
DNM1L dynamin 1-like -4.34948
ISOC1 isochorismatase domain containing 1 -4.23993
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.1031
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.06498
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.03898
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.93015
ADI1 acireductone dioxygenase 1 -3.69088
LDHD lactate dehydrogenase D -3.60763
OXA1L oxidase (cytochrome c) assembly 1-like -3.60211
CHMP4B charged multivesicular body protein 4B -3.46957
CAB39 calcium binding protein 39 -3.41888
CCNB2 cyclin B2 -3.4049
ICAM3 intercellular adhesion molecule 3 -3.13287
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.79638
EIF5 eukaryotic translation initiation factor 5 -2.73423
FASTKD5 FAST kinase domains 5 -2.65637
GNAS GNAS complex locus -2.43722
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.30806
CRELD2 cysteine-rich with EGF-like domains 2 -2.25868
MAP7 microtubule-associated protein 7 -2.17135
CXCL2 chemokine (C-X-C motif) ligand 2 -2.11997
PDLIM1 PDZ and LIM domain 1 -2.05174