CRCGN012_HEPG2_24H:P20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diallyl phthalate 19.7 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN012_HEPG2_24H:P20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 6.34849
DYNLT3 dynein, light chain, Tctex-type 3 6.05731
CCNF cyclin F 4.6708
AMDHD2 amidohydrolase domain containing 2 4.54976
HEBP1 heme binding protein 1 4.32877
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.06479
E2F2 E2F transcription factor 2 3.79076
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.56275
PPARG peroxisome proliferator-activated receptor gamma 3.44057
CARMIL1 capping protein regulator and myosin 1 linker 1 3.30449
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.16873
LYN LYN proto-oncogene, Src family tyrosine kinase 3.10193
CGRRF1 cell growth regulator with ring finger domain 1 3.01587
CSK c-src tyrosine kinase 2.99316
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.84169
PPIE peptidylprolyl isomerase E (cyclophilin E) 2.78583
CCL2 chemokine (C-C motif) ligand 2 2.73598
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.54006
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.50183
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.48433
GATA3 GATA binding protein 3 2.41256
PEX11A peroxisomal biogenesis factor 11 alpha 2.38559
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.38129
FZD7 frizzled class receptor 7 2.25805
CERS4 ceramide synthase 4 2.24122
TWNK twinkle mtDNA helicase 2.2019
MAP7 microtubule-associated protein 7 2.18157
ABHD6 abhydrolase domain containing 6 2.12398
UBA1 ubiquitin-like modifier activating enzyme 1 2.12385
NOSIP nitric oxide synthase interacting protein 2.10694
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.10002

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -7.26162
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.94677
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -4.85693
NUP93 nucleoporin 93kDa -4.47955
PECR peroxisomal trans-2-enoyl-CoA reductase -4.03854
DERA deoxyribose-phosphate aldolase (putative) -3.82597
CCNB2 cyclin B2 -3.7688
EGF epidermal growth factor -3.73997
CDC20 cell division cycle 20 -3.66573
TSPAN4 tetraspanin 4 -3.63364
COG4 component of oligomeric golgi complex 4 -3.54863
YME1L1 YME1-like 1 ATPase -3.48939
TCERG1 transcription elongation regulator 1 -3.47057
VAT1 vesicle amine transport 1 -3.29587
MAPK13 mitogen-activated protein kinase 13 -3.29028
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -3.28
TRAP1 TNF receptor-associated protein 1 -3.2622
FBXL12 F-box and leucine-rich repeat protein 12 -3.21071
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.19396
BLCAP bladder cancer associated protein -2.95608
FGFR4 fibroblast growth factor receptor 4 -2.93399
EIF5 eukaryotic translation initiation factor 5 -2.92445
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.85372
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.65428
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -2.64151
GDF15 growth differentiation factor 15 -2.61485
PSRC1 proline/serine-rich coiled-coil 1 -2.49573
UBE3C ubiquitin protein ligase E3C -2.46266
ZMIZ1 zinc finger, MIZ-type containing 1 -2.31132
APIP APAF1 interacting protein -2.27691
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.23194
CCNB1 cyclin B1 -2.22868
RPS5 ribosomal protein S5 -2.14654
FAIM Fas apoptotic inhibitory molecule -2.13687
TXNRD1 thioredoxin reductase 1 -2.13535
PCNA proliferating cell nuclear antigen -2.12951