CRCGN012_HEPG2_24H:P21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description diallyl phthalate 9.85 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN012_HEPG2_24H:P21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CSK c-src tyrosine kinase 7.28894
STK10 serine/threonine kinase 10 6.16543
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.5982
STIMATE STIM activating enhancer 4.17581
ZBTB35 zinc finger and BTB domain containing 35 3.92546
BACE2 beta-site APP-cleaving enzyme 2 3.92135
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.84665
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.53798
C2CD2 C2 calcium-dependent domain containing 2 3.49389
BZW2 basic leucine zipper and W2 domains 2 3.3143
CCNH cyclin H 3.04363
CCL2 chemokine (C-C motif) ligand 2 2.73093
KLHL9 kelch-like family member 9 2.44736
MAP7 microtubule-associated protein 7 2.38822
WDTC1 WD and tetratricopeptide repeats 1 2.09329
ABHD4 abhydrolase domain containing 4 2.08029
SPG11 spastic paraplegia 11 (autosomal recessive) 2.04771
PUM3 pumilio RNA binding family member 3 2.04562
GATA3 GATA binding protein 3 2.04492
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.02719
ELAC2 elaC ribonuclease Z 2 2.02082

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -7.79568
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -7.77252
PLK1 polo-like kinase 1 -7.68589
MRPS16 mitochondrial ribosomal protein S16 -4.54686
FAIM Fas apoptotic inhibitory molecule -4.52588
DNM1L dynamin 1-like -4.02357
NT5DC2 5'-nucleotidase domain containing 2 -4.01682
KDM3A lysine (K)-specific demethylase 3A -4.00065
LDHD lactate dehydrogenase D -3.98619
EGF epidermal growth factor -3.9602
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.8698
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.69468
ZNF586 zinc finger protein 586 -3.22339
SNX11 sorting nexin 11 -3.22321
TOMM34 translocase of outer mitochondrial membrane 34 -3.03433
PEG10 paternally expressed 10 -3.0037
MAPK13 mitogen-activated protein kinase 13 -2.8298
RNF167 ring finger protein 167 -2.71876
FBXL12 F-box and leucine-rich repeat protein 12 -2.71631
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.56516
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.5554
S100A3 S100 calcium binding protein A3 -2.4345
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.36871
CCNB2 cyclin B2 -2.35374
EIF5 eukaryotic translation initiation factor 5 -2.32381
HNMT histamine N-methyltransferase -2.27862
PDIA5 protein disulfide isomerase family A, member 5 -2.19004
CDCA3 cell division cycle associated 3 -2.154
ZNF646 zinc finger protein 646 -2.14154
CYREN cell cycle regulator of NHEJ -2.13105
PCDHGA3 protocadherin gamma subfamily A, 3 -2.1087
VAMP8 vesicle-associated membrane protein 8 -2.08588
PCDHGA1 protocadherin gamma subfamily A, 1 -2.06263
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -2.01769
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -2.01458