CRCGN013_HEPG2_24H:A06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

88 genes differentially expressed following the CRCGN013_HEPG2_24H:A06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 5.27465
LCN2 lipocalin 2 4.82825
SSBP2 single-stranded DNA binding protein 2 4.79454
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 4.67935
CIAO3 cytosolic iron-sulfur assembly component 3 4.24697
MAP3K4 mitogen-activated protein kinase kinase kinase 4 4.0191
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.97016
ANO1 anoctamin 1, calcium activated chloride channel 3.63239
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.59896
MINDY1 MINDY lysine 48 deubiquitinase 1 3.33022
GPATCH8 G patch domain containing 8 3.22146
EPHB2 EPH receptor B2 3.17234
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.15733
MYLK myosin light chain kinase 3.15558
ADRB2 adrenoceptor beta 2, surface 3.06912
RRAGA Ras-related GTP binding A 2.94279
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.93041
STIMATE STIM activating enhancer 2.70209
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.66113
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.61409
UBQLN2 ubiquilin 2 2.57979
CHMP6 charged multivesicular body protein 6 2.49557
CEP57 centrosomal protein 57kDa 2.49211
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.4899
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.47713
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.43057
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.39835
NOTCH1 notch 1 2.35758
ZNF750 zinc finger protein 750 2.3408
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 2.33814
ADAT1 adenosine deaminase, tRNA-specific 1 2.33087
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.3008
USP18 ubiquitin specific peptidase 18 2.29624
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.28983
MAGEA4 melanoma antigen family A4 2.24648
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13 2.24567
GATA2 GATA binding protein 2 2.23178
NT5DC2 5'-nucleotidase domain containing 2 2.16433
AARS1 alanyl-tRNA synthetase 1 2.16166
BACE2 beta-site APP-cleaving enzyme 2 2.14429
ALDOC aldolase C, fructose-bisphosphate 2.14079
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.124
KLHL1 kelch-like family member 1 2.11168
NRTN neurturin 2.11147
PAX9 paired box 9 2.09005
BMAL2 basic helix-loop-helix ARNT like 2 2.08706
PRR15L proline rich 15-like 2.08242
ZSCAN2 zinc finger and SCAN domain containing 2 2.07557
SMR3B submaxillary gland androgen regulated protein 3B 2.07279
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 2.06008
DGCR6L DiGeorge syndrome critical region gene 6-like 2.04547
RPAP3 RNA polymerase II associated protein 3 2.01829
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.0132
KIF25 kinesin family member 25 2.00717
TRAPPC11 trafficking protein particle complex 11 2.00611
ATG4A autophagy related 4A, cysteine peptidase 2.00436

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -8.26547
CCNB2 cyclin B2 -7.17526
PLK1 polo-like kinase 1 -4.9042
TLCD3A TLC domain containing 3A -4.50914
UGDH UDP-glucose 6-dehydrogenase -4.23745
PCNA proliferating cell nuclear antigen -3.93845
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.83706
TXNDC9 thioredoxin domain containing 9 -3.15879
GNAS GNAS complex locus -3.08825
MRPS2 mitochondrial ribosomal protein S2 -3.02252
CDC20 cell division cycle 20 -2.89229
SCAND1 SCAN domain containing 1 -2.87397
NGRN neugrin, neurite outgrowth associated -2.84082
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.71873
TM9SF3 transmembrane 9 superfamily member 3 -2.62918
MAPK13 mitogen-activated protein kinase 13 -2.54085
TOR1A torsin family 1, member A (torsin A) -2.50443
SLC35F2 solute carrier family 35, member F2 -2.42121
CRELD2 cysteine-rich with EGF-like domains 2 -2.41731
NUP93 nucleoporin 93kDa -2.32824
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.22663
EBNA1BP2 EBNA1 binding protein 2 -2.21889
SMNDC1 survival motor neuron domain containing 1 -2.13777
GLOD4 glyoxalase domain containing 4 -2.11996
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.11104
CHIC2 cysteine-rich hydrophobic domain 2 -2.09279
SPAG4 sperm associated antigen 4 -2.08588
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.06919
DSG2 desmoglein 2 -2.06433
THBS2 thrombospondin 2 -2.04475
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.03799
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.01419