CRCGN013_HEPG2_24H:A07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(9-oxo-9h-fluoren-2-yl)acetamide 20.23 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

259 genes differentially expressed following the CRCGN013_HEPG2_24H:A07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 9.74512
CNPY3 canopy FGF signaling regulator 3 9.63547
TXNRD1 thioredoxin reductase 1 9.14777
ABHD4 abhydrolase domain containing 4 9.13135
LRP10 low density lipoprotein receptor-related protein 10 7.76291
CDPF1 cysteine-rich, DPF motif domain containing 1 6.68592
SQOR sulfide quinone oxidoreductase 6.12461
H2BC12 H2B clustered histone 12 6.07459
FOSL1 FOS-like antigen 1 5.87748
SNAP25 synaptosomal-associated protein, 25kDa 5.64868
LCN2 lipocalin 2 5.63562
SQSTM1 sequestosome 1 5.57337
CBR1 carbonyl reductase 1 5.52225
TIMP2 TIMP metallopeptidase inhibitor 2 5.37452
CTSL cathepsin L 4.99127
ALAS1 5'-aminolevulinate synthase 1 4.89033
MVP major vault protein 4.75134
KIFBP kinesin family binding protein 4.45298
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.27001
CHMP6 charged multivesicular body protein 6 4.21423
BZW2 basic leucine zipper and W2 domains 2 4.16232
SRC SRC proto-oncogene, non-receptor tyrosine kinase 4.09379
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.01872
INPP1 inositol polyphosphate-1-phosphatase 3.95807
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.91052
ADRB2 adrenoceptor beta 2, surface 3.76477
RPP38 ribonuclease P/MRP 38kDa subunit 3.7616
STX1A syntaxin 1A (brain) 3.66563
PRKCD protein kinase C, delta 3.60173
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.56464
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.47815
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.36113
PRKCQ protein kinase C, theta 3.3293
UGDH UDP-glucose 6-dehydrogenase 3.26556
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.24755
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.24301
KEAP1 kelch-like ECH-associated protein 1 3.16901
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.03384
EGR1 early growth response 1 2.99129
RPL39L ribosomal protein L39-like 2.9768
BYSL bystin-like 2.96942
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.95145
RRAGA Ras-related GTP binding A 2.94834
ECD ecdysoneless homolog (Drosophila) 2.93369
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.8793
GLRX glutaredoxin (thioltransferase) 2.82976
CD48 CD48 molecule 2.82489
GCLM glutamate-cysteine ligase, modifier subunit 2.82114
H2AC6 H2A clustered histone 6 2.81384
CCDC87 coiled-coil domain containing 87 2.80005
ADAM10 ADAM metallopeptidase domain 10 2.76867
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.76654
FASTKD5 FAST kinase domains 5 2.76448
TICAM1 toll-like receptor adaptor molecule 1 2.7297
GPC1 glypican 1 2.7038
SMAD3 SMAD family member 3 2.69995
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.69739
GLI2 GLI family zinc finger 2 2.69519
H2BC9 H2B clustered histone 9 2.69181
KLHL21 kelch-like family member 21 2.69162
ABHD6 abhydrolase domain containing 6 2.68502
BLCAP bladder cancer associated protein 2.68328
ZFP36 ZFP36 ring finger protein 2.67984
MINDY1 MINDY lysine 48 deubiquitinase 1 2.67686
IL4R interleukin 4 receptor 2.66036
SFTPB surfactant protein B 2.64556
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 2.64314
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.64126
YIPF3 Yip1 domain family, member 3 2.62164
BAG2 BCL2-associated athanogene 2 2.6131
FBXO7 F-box protein 7 2.60377
SSBP2 single-stranded DNA binding protein 2 2.57939
CTTN cortactin 2.5443
MRPS2 mitochondrial ribosomal protein S2 2.50632
CDC45 cell division cycle 45 2.47936
CBR3 carbonyl reductase 3 2.47798
TBCC tubulin folding cofactor C 2.46365
DGKG diacylglycerol kinase, gamma 90kDa 2.44444
DOLK dolichol kinase 2.44312
BLVRA biliverdin reductase A 2.43311
FPGS folylpolyglutamate synthase 2.43247
RALB v-ral simian leukemia viral oncogene homolog B 2.38944
GCLC glutamate-cysteine ligase, catalytic subunit 2.37523
ELL2 elongation factor, RNA polymerase II, 2 2.36414
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.34451
GATA3 GATA binding protein 3 2.33163
HABP4 hyaluronan binding protein 4 2.3238
DNM1L dynamin 1-like 2.32188
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.3102
TREM2 triggering receptor expressed on myeloid cells 2 2.30048
CLK3 CDC-like kinase 3 2.29465
TMEM50A transmembrane protein 50A 2.27587
CCDC86 coiled-coil domain containing 86 2.26825
GSTZ1 glutathione S-transferase zeta 1 2.25176
STIMATE STIM activating enhancer 2.25084
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.24728
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.242
C1QL1 complement component 1, q subcomponent-like 1 2.23563
NABP1 nucleic acid binding protein 1 2.2239
TUBB6 tubulin, beta 6 class V 2.21953
GMPR guanosine monophosphate reductase 2.21134
MCOLN1 mucolipin 1 2.20541
MC3R melanocortin 3 receptor 2.20474
CDK6 cyclin-dependent kinase 6 2.19517
YAP1 Yes-associated protein 1 2.19453
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.19048
CHERP calcium homeostasis endoplasmic reticulum protein 2.17379
RCVRN recoverin 2.1728
H1-2 H1.2 linker histone, cluster member 2.16933
CUL1 cullin 1 2.15522
SDF2 stromal cell-derived factor 2 2.15034
CASS4 Cas scaffolding protein family member 4 2.14451
OVOL3 ovo-like zinc finger 3 2.14196
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.14106
TEC tec protein tyrosine kinase 2.13958
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.13035
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.11737
SEZ6L seizure related 6 homolog (mouse)-like 2.10481
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.0961
TRIB1 tribbles pseudokinase 1 2.09591
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.09067
CLDN11 claudin 11 2.09063
TALDO1 transaldolase 1 2.08561
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.08129
GARRE1 granule associated Rac and RHOG effector 1 2.07593
CD151 CD151 molecule (Raph blood group) 2.05159
FAAP20 FA core complex associated protein 20 2.04956
TXK TXK tyrosine kinase 2.04314
ADGRE5 adhesion G protein-coupled receptor E5 2.04143
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 2.04089
KDM3A lysine (K)-specific demethylase 3A 2.03848
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 2.03688
RAB27B RAB27B, member RAS oncogene family 2.03658
MMP1 matrix metallopeptidase 1 2.0286
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.02826
IFNB1 interferon, beta 1, fibroblast 2.02787
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.02297
GPATCH3 G patch domain containing 3 2.02101
OR1D4 olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene) 2.01403
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.012
CTSF cathepsin F 2.01127
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 2.01025
PACC1 proton activated chloride channel 1 2.00412
COL4A1 collagen, type IV, alpha 1 2.00158

decreased expression

Symbol Name Standardized Value
UBE2C ubiquitin-conjugating enzyme E2C -6.86584
PECR peroxisomal trans-2-enoyl-CoA reductase -6.69912
LDHD lactate dehydrogenase D -6.51187
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -6.27648
PLK1 polo-like kinase 1 -6.16709
C5 complement component 5 -5.73986
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -5.44545
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.24219
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -5.23442
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -5.01303
ISOC1 isochorismatase domain containing 1 -4.57811
AURKB aurora kinase B -4.52325
NUP93 nucleoporin 93kDa -4.47233
TOP2A topoisomerase (DNA) II alpha 170kDa -4.37246
FGFR4 fibroblast growth factor receptor 4 -4.18616
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.18483
HAT1 histone acetyltransferase 1 -4.09139
HMGA2 high mobility group AT-hook 2 -4.07062
CDK1 cyclin-dependent kinase 1 -3.97014
DDB2 damage-specific DNA binding protein 2, 48kDa -3.91576
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.82134
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.71836
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -3.67061
MELK maternal embryonic leucine zipper kinase -3.65052
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.64818
PSRC1 proline/serine-rich coiled-coil 1 -3.49286
TCTN1 tectonic family member 1 -3.43704
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.40664
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -3.37575
SOAT2 sterol O-acyltransferase 2 -3.34535
IMPACT impact RWD domain protein -3.29982
OXA1L oxidase (cytochrome c) assembly 1-like -3.29659
ZW10 zw10 kinetochore protein -3.27331
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.26555
CCNA2 cyclin A2 -3.23938
PYCR1 pyrroline-5-carboxylate reductase 1 -3.22561
CDC20 cell division cycle 20 -3.15054
ZMIZ1 zinc finger, MIZ-type containing 1 -3.1234
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.11397
CCP110 centriolar coiled coil protein 110kDa -3.09955
PROS1 protein S (alpha) -3.07764
NUP85 nucleoporin 85kDa -3.00319
HADH hydroxyacyl-CoA dehydrogenase -2.97093
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.9451
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.9339
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.92692
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.87069
RPS5 ribosomal protein S5 -2.86334
RFC2 replication factor C (activator 1) 2, 40kDa -2.81666
TMEM97 transmembrane protein 97 -2.81139
C2CD5 C2 calcium-dependent domain containing 5 -2.79268
GAA glucosidase, alpha; acid -2.77294
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.75171
GNAS GNAS complex locus -2.69147
GID8 GID complex subunit 8 -2.64158
USP22 ubiquitin specific peptidase 22 -2.59939
ASF1B anti-silencing function 1B histone chaperone -2.56794
ANKRD46 ankyrin repeat domain 46 -2.56092
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.55017
PCCB propionyl CoA carboxylase, beta polypeptide -2.53025
CHEK2 checkpoint kinase 2 -2.47969
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.4716
NT5DC2 5'-nucleotidase domain containing 2 -2.44826
HTRA1 HtrA serine peptidase 1 -2.43656
ENOPH1 enolase-phosphatase 1 -2.4199
CETN3 centrin, EF-hand protein, 3 -2.40399
VAT1 vesicle amine transport 1 -2.38903
S100A4 S100 calcium binding protein A4 -2.37217
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.3673
CRIPTO3 cripto, EGF-CFC family member 3 -2.36609
KIF14 kinesin family member 14 -2.35709
CDCA8 cell division cycle associated 8 -2.34368
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.33217
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.32743
ERI2 ERI1 exoribonuclease family member 2 -2.31883
DSCC1 DNA replication and sister chromatid cohesion 1 -2.30842
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.30479
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.29448
NEK4 NIMA-related kinase 4 -2.29016
PRCP prolylcarboxypeptidase (angiotensinase C) -2.28768
CAB39 calcium binding protein 39 -2.26767
EIF5 eukaryotic translation initiation factor 5 -2.26359
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.23908
KIF15 kinesin family member 15 -2.23901
BIRC5 baculoviral IAP repeat containing 5 -2.2233
NGRN neugrin, neurite outgrowth associated -2.21557
FABP1 fatty acid binding protein 1, liver -2.21015
CETN2 centrin, EF-hand protein, 2 -2.20675
PGM1 phosphoglucomutase 1 -2.20518
FANCG Fanconi anemia, complementation group G -2.19169
LOC124907782 dual specificity protein phosphatase 22 -2.19125
FBXL12 F-box and leucine-rich repeat protein 12 -2.18466
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.17149
AZIN1 antizyme inhibitor 1 -2.16943
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.13163
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.12281
COG7 component of oligomeric golgi complex 7 -2.11509
ARID3A AT rich interactive domain 3A (BRIGHT-like) -2.10958
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.1093
DOCK4 dedicator of cytokinesis 4 -2.10742
NUDCD3 NudC domain containing 3 -2.10226
TFDP1 transcription factor Dp-1 -2.09329
DNAAF5 dynein, axonemal, assembly factor 5 -2.08199
DPYSL2 dihydropyrimidinase-like 2 -2.07989
CCNF cyclin F -2.07761
SESN1 sestrin 1 -2.07436
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.07362
USP1 ubiquitin specific peptidase 1 -2.05508
NCAPG2 non-SMC condensin II complex, subunit G2 -2.04203
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.02886
TDP1 tyrosyl-DNA phosphodiesterase 1 -2.02297
FOXM1 forkhead box M1 -2.01267
GLOD4 glyoxalase domain containing 4 -2.0125
TSPAN4 tetraspanin 4 -2.00352
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.00118