CRCGN013_HEPG2_24H:A08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-(9-oxo-9h-fluoren-2-yl)acetamide 10.12 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

122 genes differentially expressed following the CRCGN013_HEPG2_24H:A08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNPY3 canopy FGF signaling regulator 3 7.93822
HMOX1 heme oxygenase 1 7.88515
LCN2 lipocalin 2 6.83808
CHMP6 charged multivesicular body protein 6 6.29244
LRP10 low density lipoprotein receptor-related protein 10 5.7133
TXNRD1 thioredoxin reductase 1 5.40937
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.7959
GPER1 G protein-coupled estrogen receptor 1 4.67289
HLA-DRA major histocompatibility complex, class II, DR alpha 4.23898
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.17402
TIMP2 TIMP metallopeptidase inhibitor 2 4.13872
PNKP polynucleotide kinase 3'-phosphatase 4.02177
ALAS1 5'-aminolevulinate synthase 1 4.01261
RPP38 ribonuclease P/MRP 38kDa subunit 3.88712
H2BC12 H2B clustered histone 12 3.87664
CTSL cathepsin L 3.85813
MAP7 microtubule-associated protein 7 3.7868
MVP major vault protein 3.71703
ABHD4 abhydrolase domain containing 4 3.71529
INPP1 inositol polyphosphate-1-phosphatase 3.57338
SQSTM1 sequestosome 1 3.51513
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.32637
CBR1 carbonyl reductase 1 3.29877
FOSL1 FOS-like antigen 1 3.21827
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.16028
MAMLD1 mastermind-like domain containing 1 3.15921
C2CD2 C2 calcium-dependent domain containing 2 3.00634
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.9213
BZW2 basic leucine zipper and W2 domains 2 2.73822
E2F2 E2F transcription factor 2 2.70938
CYCS cytochrome c, somatic 2.67008
CHN1 chimerin 1 2.64861
CDPF1 cysteine-rich, DPF motif domain containing 1 2.64082
DIPK1A divergent protein kinase domain 1A 2.60583
CDC45 cell division cycle 45 2.57702
SSBP2 single-stranded DNA binding protein 2 2.55388
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.5355
GLRX glutaredoxin (thioltransferase) 2.47595
SNAP25 synaptosomal-associated protein, 25kDa 2.46871
RALB v-ral simian leukemia viral oncogene homolog B 2.46811
TBP TATA box binding protein 2.43323
ADAT1 adenosine deaminase, tRNA-specific 1 2.42307
BLVRA biliverdin reductase A 2.41966
SKIC2 SKI2 subunit of superkiller complex 2.37466
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 2.37117
ECD ecdysoneless homolog (Drosophila) 2.35313
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.35258
STK10 serine/threonine kinase 10 2.31419
SLC35F2 solute carrier family 35, member F2 2.25166
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 2.19329
DUSP3 dual specificity phosphatase 3 2.18963
ELL2 elongation factor, RNA polymerase II, 2 2.18742
UGDH UDP-glucose 6-dehydrogenase 2.18581
PRKCD protein kinase C, delta 2.18262
SMCP sperm mitochondria-associated cysteine-rich protein 2.17664
KEAP1 kelch-like ECH-associated protein 1 2.17307
RBKS ribokinase 2.16225
CDKN2A cyclin-dependent kinase inhibitor 2A 2.10274
SQOR sulfide quinone oxidoreductase 2.08141
BLCAP bladder cancer associated protein 2.07772
IGF2R insulin-like growth factor 2 receptor 2.0769
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.07083
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.06159
EGR1 early growth response 1 2.02468
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.02305
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 2.02085
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.01379
SLC44A4 solute carrier family 44, member 4 2.00757

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.72568
LDHD lactate dehydrogenase D -6.37091
UBE2C ubiquitin-conjugating enzyme E2C -5.35071
C5 complement component 5 -4.94137
PECR peroxisomal trans-2-enoyl-CoA reductase -4.55605
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -4.37649
AURKB aurora kinase B -4.29727
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.27625
NT5DC2 5'-nucleotidase domain containing 2 -4.23762
HSPB1 heat shock 27kDa protein 1 -4.05764
ISOC1 isochorismatase domain containing 1 -3.85476
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.81534
TRIB3 tribbles pseudokinase 3 -3.67768
CCNB2 cyclin B2 -3.63837
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.47318
TOPBP1 topoisomerase (DNA) II binding protein 1 -3.35281
CRELD2 cysteine-rich with EGF-like domains 2 -3.30594
CCNB1 cyclin B1 -3.27034
EDN1 endothelin 1 -3.18404
KDM3A lysine (K)-specific demethylase 3A -3.15094
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.97526
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.96007
CDK1 cyclin-dependent kinase 1 -2.92668
TMEM97 transmembrane protein 97 -2.87625
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.84589
TOP2A topoisomerase (DNA) II alpha 170kDa -2.84055
CCP110 centriolar coiled coil protein 110kDa -2.79927
PSRC1 proline/serine-rich coiled-coil 1 -2.75079
PLK1 polo-like kinase 1 -2.60434
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.57329
NRIP1 nuclear receptor interacting protein 1 -2.57076
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.52242
FHL2 four and a half LIM domains 2 -2.49128
PYCR1 pyrroline-5-carboxylate reductase 1 -2.47448
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.45489
DDIT4 DNA-damage-inducible transcript 4 -2.39548
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.25583
SOAT2 sterol O-acyltransferase 2 -2.25502
ADI1 acireductone dioxygenase 1 -2.23503
NGRN neugrin, neurite outgrowth associated -2.2166
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.20423
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -2.20313
STMN1 stathmin 1 -2.20152
KIF14 kinesin family member 14 -2.19023
LBR lamin B receptor -2.18962
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.18003
KIF11 kinesin family member 11 -2.13621
USP6NL USP6 N-terminal like -2.1305
HSPA1A heat shock 70kDa protein 1A -2.1081
YEATS4 YEATS domain containing 4 -2.10081
ANKRD46 ankyrin repeat domain 46 -2.09775
DSCC1 DNA replication and sister chromatid cohesion 1 -2.07007
HMGA2 high mobility group AT-hook 2 -2.04911
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.0254