CRCGN013_HEPG2_24H:A15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyleugenol 10.1 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

52 genes differentially expressed following the CRCGN013_HEPG2_24H:A15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 6.45777
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.23121
AMDHD2 amidohydrolase domain containing 2 4.7557
CBR3 carbonyl reductase 3 4.34903
SSBP2 single-stranded DNA binding protein 2 4.15543
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 4.0626
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.58188
PLSCR1 phospholipid scramblase 1 3.53949
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 3.2121
LYN LYN proto-oncogene, Src family tyrosine kinase 3.20758
NOTCH1 notch 1 3.12356
EPN2 epsin 2 3.0532
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.88425
HLA-DRA major histocompatibility complex, class II, DR alpha 2.83049
RPP38 ribonuclease P/MRP 38kDa subunit 2.72576
MTERF3 mitochondrial transcription termination factor 3 2.65806
ISG15 ISG15 ubiquitin-like modifier 2.63063
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.62276
FPGS folylpolyglutamate synthase 2.58741
TIAM1 T-cell lymphoma invasion and metastasis 1 2.50427
ADAT1 adenosine deaminase, tRNA-specific 1 2.49809
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.46998
MX1 MX dynamin-like GTPase 1 2.42347
ATP11B ATPase, class VI, type 11B 2.28994
ABHD6 abhydrolase domain containing 6 2.22371
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.21501
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.18074
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.17455
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.17004
RSAD2 radical S-adenosyl methionine domain containing 2 2.13964
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.12916
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.11193
UBQLN2 ubiquilin 2 2.06814
RIGI RNA sensor RIG-I 2.06612
MX2 MX dynamin-like GTPase 2 2.01208

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -6.39673
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.2454
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.37892
RAI14 retinoic acid induced 14 -4.36488
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -3.62219
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.49364
CCNB2 cyclin B2 -3.47695
SLC35F2 solute carrier family 35, member F2 -3.35229
RGS2 regulator of G-protein signaling 2 -3.23169
LDHD lactate dehydrogenase D -3.21672
GDF15 growth differentiation factor 15 -3.03389
NVL nuclear VCP-like -2.85989
CD320 CD320 molecule -2.80182
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.44487
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.32971
RNF167 ring finger protein 167 -2.2118
GNAS GNAS complex locus -2.17082