CRCGN013_HEPG2_24H:A17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methyleugenol 2.52 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

71 genes differentially expressed following the CRCGN013_HEPG2_24H:A17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 4.93175
CCL2 chemokine (C-C motif) ligand 2 4.80993
CHMP6 charged multivesicular body protein 6 4.75893
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.71658
NOTCH1 notch 1 4.40102
CARMIL1 capping protein regulator and myosin 1 linker 1 4.31883
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.06674
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.9295
GRWD1 glutamate-rich WD repeat containing 1 3.69523
CXCR4 chemokine (C-X-C motif) receptor 4 3.52214
CASP10 caspase 10, apoptosis-related cysteine peptidase 3.51344
PEX11A peroxisomal biogenesis factor 11 alpha 3.35414
MMP2 matrix metallopeptidase 2 3.12064
SSBP2 single-stranded DNA binding protein 2 3.11041
SHB Src homology 2 domain containing adaptor protein B 3.01087
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.85496
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.57783
ANKRD36C ankyrin repeat domain 36C 2.47407
ZFP36 ZFP36 ring finger protein 2.43997
TENT4A terminal nucleotidyltransferase 4A 2.37814
TREM1 triggering receptor expressed on myeloid cells 1 2.3719
SH3D19 SH3 domain containing 19 2.37182
HEG1 heart development protein with EGF-like domains 1 2.31523
RGPD2 RANBP2-like and GRIP domain containing 2 2.30862
RNF103-CHMP3 RNF103-CHMP3 readthrough 2.27166
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.24749
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.23711
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.20961
MEST mesoderm specific transcript 2.16966
HEBP2 heme binding protein 2 2.15661
GPA33 glycoprotein A33 (transmembrane) 2.13825
GPATCH8 G patch domain containing 8 2.11611
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.09347
PTK2 protein tyrosine kinase 2 2.09072
MAP7 microtubule-associated protein 7 2.08483
BRD7 bromodomain containing 7 2.07689
CSE1L CSE1 chromosome segregation 1-like (yeast) 2.07417
MMP15 matrix metallopeptidase 15 (membrane-inserted) 2.06418
FAM124B family with sequence similarity 124B 2.04257
NELL2 NEL-like 2 (chicken) 2.01623
VIL1 villin 1 2.01581
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 2.00529
CERK ceramide kinase 2.00256

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -7.01729
CCNB2 cyclin B2 -6.9177
GOLT1B golgi transport 1B -5.48217
VAT1 vesicle amine transport 1 -4.95617
TM9SF3 transmembrane 9 superfamily member 3 -4.81644
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.6862
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.93996
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.9397
HMG20B high mobility group 20B -3.84216
EGF epidermal growth factor -3.65273
SNX11 sorting nexin 11 -3.63827
S100A4 S100 calcium binding protein A4 -3.41577
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.69439
GPR137B G protein-coupled receptor 137B -2.58749
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.48846
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) -2.38396
OXA1L oxidase (cytochrome c) assembly 1-like -2.37648
EED embryonic ectoderm development -2.36292
MALT1 MALT1 paracaspase -2.32733
HLA-DMA major histocompatibility complex, class II, DM alpha -2.28052
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.21887
WDR83OS WD repeat domain 83 opposite strand -2.11678
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.10636
GAK cyclin G associated kinase -2.09046
CCL17 chemokine (C-C motif) ligand 17 -2.07337
MGST3 microsomal glutathione S-transferase 3 -2.07238
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -2.05693
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.00689