CRCGN013_HEPG2_24H:A19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenformin 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

241 genes differentially expressed following the CRCGN013_HEPG2_24H:A19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GSTZ1 glutathione S-transferase zeta 1 8.3049
TIMP2 TIMP metallopeptidase inhibitor 2 7.58592
CNPY3 canopy FGF signaling regulator 3 7.15535
INPP1 inositol polyphosphate-1-phosphatase 6.45441
LRP10 low density lipoprotein receptor-related protein 10 6.39996
KIFBP kinesin family binding protein 6.07335
SSBP2 single-stranded DNA binding protein 2 5.58493
TRIB3 tribbles pseudokinase 3 5.3677
NR1H2 nuclear receptor subfamily 1, group H, member 2 5.13028
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.74807
MVP major vault protein 4.48378
CDPF1 cysteine-rich, DPF motif domain containing 1 4.4403
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 4.16715
STK10 serine/threonine kinase 10 3.76762
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.76193
UBQLN2 ubiquilin 2 3.64671
NOTCH1 notch 1 3.61427
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.4811
TXNRD1 thioredoxin reductase 1 3.4801
NPC1 Niemann-Pick disease, type C1 3.14234
EGR1 early growth response 1 3.13792
CHN1 chimerin 1 3.09358
BLVRA biliverdin reductase A 3.06619
SQSTM1 sequestosome 1 3.04155
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.0256
E2F2 E2F transcription factor 2 3.00881
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.98891
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.98701
GLRX glutaredoxin (thioltransferase) 2.98196
BACE2 beta-site APP-cleaving enzyme 2 2.95136
AARS1 alanyl-tRNA synthetase 1 2.93254
PPARG peroxisome proliferator-activated receptor gamma 2.87879
LOC102724560 cystathionine beta-synthase 2.87739
GRB10 growth factor receptor-bound protein 10 2.8547
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.85106
IER3 immediate early response 3 2.81177
CTSL cathepsin L 2.81073
YIPF3 Yip1 domain family, member 3 2.80382
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.77882
MTERF3 mitochondrial transcription termination factor 3 2.73548
RAP1GAP RAP1 GTPase activating protein 2.73264
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.71909
ZFP36 ZFP36 ring finger protein 2.64731
SUN2 Sad1 and UNC84 domain containing 2 2.64007
NANOS3 nanos homolog 3 (Drosophila) 2.63081
TRIB1 tribbles pseudokinase 1 2.6249
IL4R interleukin 4 receptor 2.59868
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.57812
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.57351
DSG2 desmoglein 2 2.57025
ATF4 activating transcription factor 4 2.5681
PDGFA platelet-derived growth factor alpha polypeptide 2.54775
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.51798
FEZF2 FEZ family zinc finger 2 2.51466
YARS1 tyrosyl-tRNA synthetase 1 2.49974
GTPBP2 GTP binding protein 2 2.49199
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.47834
CSNK1E casein kinase 1, epsilon 2.45665
ACOT9 acyl-CoA thioesterase 9 2.44145
HAPLN1 hyaluronan and proteoglycan link protein 1 2.43308
RALB v-ral simian leukemia viral oncogene homolog B 2.39859
SQOR sulfide quinone oxidoreductase 2.39816
SARS1 seryl-tRNA synthetase 1 2.37968
DPP4 dipeptidyl-peptidase 4 2.37929
STAP2 signal transducing adaptor family member 2 2.37366
FOSL1 FOS-like antigen 1 2.33603
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.33152
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.31879
MAPK12 mitogen-activated protein kinase 12 2.3005
MAPK13 mitogen-activated protein kinase 13 2.29797
ADAT1 adenosine deaminase, tRNA-specific 1 2.28795
SORBS3 sorbin and SH3 domain containing 3 2.27941
CNTNAP3B contactin associated protein-like 3B 2.27722
ZNF589 zinc finger protein 589 2.27033
MAST2 microtubule associated serine/threonine kinase 2 2.25995
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.25909
TIAM1 T-cell lymphoma invasion and metastasis 1 2.25508
SOX4 SRY (sex determining region Y)-box 4 2.25309
JOSD1 Josephin domain containing 1 2.24599
CERK ceramide kinase 2.24329
ARID4B AT rich interactive domain 4B (RBP1-like) 2.23958
AMPD2 adenosine monophosphate deaminase 2 2.23663
EIF3D eukaryotic translation initiation factor 3, subunit D 2.22334
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.20324
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2.1967
UFM1 ubiquitin-fold modifier 1 2.19492
MACF1 microtubule-actin crosslinking factor 1 2.18585
PLS1 plastin 1 2.16126
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 2.15898
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.14875
ELF4 E74-like factor 4 (ets domain transcription factor) 2.14207
PVR poliovirus receptor 2.12839
RAB9A RAB9A, member RAS oncogene family 2.12811
OPN1MW3 opsin 1, medium wave sensitive 3 2.12156
EIF6 eukaryotic translation initiation factor 6 2.12036
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.10746
SLC35F2 solute carrier family 35, member F2 2.10172
MARS1 methionyl-tRNA synthetase 1 2.09506
H2AC6 H2A clustered histone 6 2.09159
SKIC2 SKI2 subunit of superkiller complex 2.08622
PLXNB2 plexin B2 2.0799
WDR13 WD repeat domain 13 2.07782
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.07504
MAN2A1 mannosidase, alpha, class 2A, member 1 2.06821
CAMTA2 calmodulin binding transcription activator 2 2.06736
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.04697
RBM15B RNA binding motif protein 15B 2.04383
S100A13 S100 calcium binding protein A13 2.03891
TRAF5 TNF receptor-associated factor 5 2.03314
SKIC3 SKI3 subunit of superkiller complex 2.02192
OFD1 oral-facial-digital syndrome 1 2.02022

decreased expression

Symbol Name Standardized Value
TMEM109 transmembrane protein 109 -6.76196
LDHD lactate dehydrogenase D -6.533
CDC20 cell division cycle 20 -6.00583
ISOC1 isochorismatase domain containing 1 -5.71696
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.66628
AURKB aurora kinase B -5.47045
RFC2 replication factor C (activator 1) 2, 40kDa -5.42732
UBE2C ubiquitin-conjugating enzyme E2C -5.33599
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -5.21079
MELK maternal embryonic leucine zipper kinase -5.19134
GNAS GNAS complex locus -4.90134
CDK1 cyclin-dependent kinase 1 -4.69356
CCNB2 cyclin B2 -4.65281
PLK1 polo-like kinase 1 -4.36257
PSRC1 proline/serine-rich coiled-coil 1 -4.12543
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.11277
CCNA2 cyclin A2 -3.97089
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -3.90475
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.88196
TOP2A topoisomerase (DNA) II alpha 170kDa -3.83123
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.83013
TMEM97 transmembrane protein 97 -3.75959
KIF14 kinesin family member 14 -3.72853
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.59845
TCTN1 tectonic family member 1 -3.57447
ZW10 zw10 kinetochore protein -3.56106
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -3.54559
HSPB1 heat shock 27kDa protein 1 -3.53377
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.45603
PGAM4 phosphoglycerate mutase family member 4 -3.42047
BIRC5 baculoviral IAP repeat containing 5 -3.36095
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -3.24353
ALDOC aldolase C, fructose-bisphosphate -3.16718
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) -3.14753
ZNF274 zinc finger protein 274 -3.14656
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.1405
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.13991
PPIC peptidylprolyl isomerase C (cyclophilin C) -3.13597
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.12057
STMN1 stathmin 1 -3.10464
POLR1A polymerase (RNA) I polypeptide A, 194kDa -3.03328
LBR lamin B receptor -3.01277
MLEC malectin -2.98275
C5 complement component 5 -2.96428
ITGB1BP1 integrin beta 1 binding protein 1 -2.85859
RNASE7 ribonuclease, RNase A family, 7 -2.84779
MCM10 minichromosome maintenance complex component 10 -2.81333
ASF1B anti-silencing function 1B histone chaperone -2.79591
FANCI Fanconi anemia, complementation group I -2.79177
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.76
HMOX1 heme oxygenase 1 -2.75808
NUP85 nucleoporin 85kDa -2.73162
SPAG5 sperm associated antigen 5 -2.71405
EGF epidermal growth factor -2.70813
TP53RK TP53 regulating kinase -2.67027
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.61711
TBC1D10C TBC1 domain family, member 10C -2.60476
BLCAP bladder cancer associated protein -2.59237
NT5DC2 5'-nucleotidase domain containing 2 -2.58579
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.58501
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.58039
SOAT2 sterol O-acyltransferase 2 -2.54839
FANCG Fanconi anemia, complementation group G -2.54436
MIS18A MIS18 kinetochore protein A -2.51922
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.5004
CHEK2 checkpoint kinase 2 -2.49833
TM7SF2 transmembrane 7 superfamily member 2 -2.49481
TMCO1 transmembrane and coiled-coil domains 1 -2.47295
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.46074
FEN1 flap structure-specific endonuclease 1 -2.44725
LAGE3 L antigen family, member 3 -2.44693
NCAPH non-SMC condensin I complex, subunit H -2.44106
FBXL12 F-box and leucine-rich repeat protein 12 -2.43446
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.42976
USP1 ubiquitin specific peptidase 1 -2.42895
DBF4 DBF4 zinc finger -2.40821
BLM Bloom syndrome, RecQ helicase-like -2.4058
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.4037
CCP110 centriolar coiled coil protein 110kDa -2.39619
PGRMC1 progesterone receptor membrane component 1 -2.37169
HAT1 histone acetyltransferase 1 -2.36585
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.3635
CDC6 cell division cycle 6 -2.34317
SPDEF SAM pointed domain containing ETS transcription factor -2.32217
INTS3 integrator complex subunit 3 -2.30363
TLR4 toll-like receptor 4 -2.30197
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.30078
LAP3 leucine aminopeptidase 3 -2.28488
KHK ketohexokinase (fructokinase) -2.2699
KIFC1 kinesin family member C1 -2.26067
SLC66A2 solute carrier family 66 member 2 -2.25939
GTF2A2 general transcription factor IIA, 2, 12kDa -2.25896
RECQL4 RecQ protein-like 4 -2.2273
UBE3B ubiquitin protein ligase E3B -2.22504
DDB2 damage-specific DNA binding protein 2, 48kDa -2.22316
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.2115
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.20753
NUP107 nucleoporin 107kDa -2.20294
TTK TTK protein kinase -2.18958
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.17819
TMEM176A transmembrane protein 176A -2.17003
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa -2.16991
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.16632
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.16236
TEX10 testis expressed 10 -2.12499
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.11327
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.11084
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -2.10402
NCAPG2 non-SMC condensin II complex, subunit G2 -2.10261
CENPA centromere protein A -2.0866
TK1 thymidine kinase 1, soluble -2.07889
PLAAT4 phospholipase A and acyltransferase 4 -2.07811
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.07689
CDCA3 cell division cycle associated 3 -2.07611
ASRGL1 asparaginase like 1 -2.07528
VRK1 vaccinia related kinase 1 -2.06545
DHCR7 7-dehydrocholesterol reductase -2.06447
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.06078
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.05971
SPDL1 spindle apparatus coiled-coil protein 1 -2.05511
SNRPF small nuclear ribonucleoprotein polypeptide F -2.05483
ACO1 aconitase 1, soluble -2.0543
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.04284
INTS5 integrator complex subunit 5 -2.04214
TPX2 TPX2, microtubule-associated -2.01848
ATP5MF ATP synthase membrane subunit f -2.01341
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) -2.00761
CHEK1 checkpoint kinase 1 -2.00653
PCNA proliferating cell nuclear antigen -2.00648
CCNF cyclin F -2.00121