CRCGN013_HEPG2_24H:A20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenformin 19.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN013_HEPG2_24H:A20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.44982
CDC45 cell division cycle 45 5.31001
SOCS2 suppressor of cytokine signaling 2 4.62263
MAP7 microtubule-associated protein 7 4.37087
TIAM1 T-cell lymphoma invasion and metastasis 1 4.25529
ADGRE5 adhesion G protein-coupled receptor E5 4.2186
CIAO3 cytosolic iron-sulfur assembly component 3 3.47789
LCN2 lipocalin 2 3.31013
SYNE2 spectrin repeat containing, nuclear envelope 2 3.2714
CBR3 carbonyl reductase 3 3.1787
ADAT1 adenosine deaminase, tRNA-specific 1 3.13775
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.97983
INPP1 inositol polyphosphate-1-phosphatase 2.84058
SSBP2 single-stranded DNA binding protein 2 2.82845
UBQLN2 ubiquilin 2 2.74337
CCNF cyclin F 2.73787
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.72765
SKIC2 SKI2 subunit of superkiller complex 2.6508
MVP major vault protein 2.63281
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.5875
CNPY3 canopy FGF signaling regulator 3 2.54711
GLRX glutaredoxin (thioltransferase) 2.31062
PTK2 protein tyrosine kinase 2 2.26482
CDPF1 cysteine-rich, DPF motif domain containing 1 2.25682
STX1A syntaxin 1A (brain) 2.20189
CHGB chromogranin B 2.10906
TXNL4B thioredoxin-like 4B 2.10347
GAA glucosidase, alpha; acid 2.06516
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.03509
WARS1 tryptophanyl-tRNA synthetase 1 2.03309

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.3522
ADI1 acireductone dioxygenase 1 -6.25228
PCNA proliferating cell nuclear antigen -5.65267
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.02653
KDM3A lysine (K)-specific demethylase 3A -3.8744
GOLT1B golgi transport 1B -3.80108
LDHD lactate dehydrogenase D -3.60516
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.54942
CD320 CD320 molecule -3.32829
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -3.26109
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.04907
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.01612
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.93525
NRIP1 nuclear receptor interacting protein 1 -2.81559
AURKB aurora kinase B -2.54462
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.49242
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.44415
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.41289
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.31508
PEG10 paternally expressed 10 -2.30364
UBE2C ubiquitin-conjugating enzyme E2C -2.30033
MELK maternal embryonic leucine zipper kinase -2.26099
MAPK13 mitogen-activated protein kinase 13 -2.25136
YME1L1 YME1-like 1 ATPase -2.21764
STMN1 stathmin 1 -2.16336
PSRC1 proline/serine-rich coiled-coil 1 -2.10634
CCNA2 cyclin A2 -2.10539
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.07099
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 -2.04759
LBR lamin B receptor -2.04671
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.04468
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.04321
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.04252
RNF167 ring finger protein 167 -2.0361
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.013
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.00938