CRCGN013_HEPG2_24H:A21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenformin 9.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN013_HEPG2_24H:A21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 7.41162
CHMP6 charged multivesicular body protein 6 7.21457
PNKP polynucleotide kinase 3'-phosphatase 5.66256
CHN1 chimerin 1 5.3192
AMDHD2 amidohydrolase domain containing 2 5.11767
LCN2 lipocalin 2 4.46231
HSPA1A heat shock 70kDa protein 1A 3.7385
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.65072
CDC45 cell division cycle 45 3.17987
GSTZ1 glutathione S-transferase zeta 1 3.02077
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.96412
RPP38 ribonuclease P/MRP 38kDa subunit 2.89749
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.8744
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.79033
ADRB2 adrenoceptor beta 2, surface 2.74043
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.56488
ZNF589 zinc finger protein 589 2.51017
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.46577
NOTCH1 notch 1 2.35861
CDK19 cyclin-dependent kinase 19 2.23406

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -4.80013
NUP85 nucleoporin 85kDa -4.35391
RAI14 retinoic acid induced 14 -3.76025
GNAS GNAS complex locus -3.51042
OXA1L oxidase (cytochrome c) assembly 1-like -3.32898
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.68594
LDHD lactate dehydrogenase D -2.67426
ARID5B AT rich interactive domain 5B (MRF1-like) -2.48702
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.451
SNX11 sorting nexin 11 -2.41658
EGF epidermal growth factor -2.41293
TRAPPC6A trafficking protein particle complex 6A -2.39427
GDF15 growth differentiation factor 15 -2.33475
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.32798
CCNB2 cyclin B2 -2.29038
CDR2L cerebellar degeneration-related protein 2-like -2.28923
MRPS7 mitochondrial ribosomal protein S7 -2.2338
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.22527
COG2 component of oligomeric golgi complex 2 -2.21243
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.21207
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.04929
WASHC4 WASH complex subunit 4 -2.04858
ELOVL1 ELOVL fatty acid elongase 1 -2.03081