CRCGN013_HEPG2_24H:A24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenformin 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN013_HEPG2_24H:A24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 6.23067
MYLK myosin light chain kinase 4.4461
CHN1 chimerin 1 3.9633
LCN2 lipocalin 2 3.63603
HLA-DMA major histocompatibility complex, class II, DM alpha 3.29452
NOSIP nitric oxide synthase interacting protein 3.20381
CDPF1 cysteine-rich, DPF motif domain containing 1 3.13445
ADAT1 adenosine deaminase, tRNA-specific 1 3.08238
CIAO3 cytosolic iron-sulfur assembly component 3 2.91042
USP6NL USP6 N-terminal like 2.83242
SSBP2 single-stranded DNA binding protein 2 2.80625
HOXA10 homeobox A10 2.66189
GPER1 G protein-coupled estrogen receptor 1 2.59249
WASF3 WAS protein family, member 3 2.53688
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.43994
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.18649
LRP10 low density lipoprotein receptor-related protein 10 2.1701
ANO1 anoctamin 1, calcium activated chloride channel 2.05708

decreased expression

Symbol Name Standardized Value
SLC35F2 solute carrier family 35, member F2 -4.31692
ACOT9 acyl-CoA thioesterase 9 -4.14882
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.1054
LDHD lactate dehydrogenase D -3.88902
NRIP1 nuclear receptor interacting protein 1 -3.19098
CHMP4B charged multivesicular body protein 4B -3.07003
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.01928
PTPRK protein tyrosine phosphatase, receptor type, K -2.8353
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.72408
RNF167 ring finger protein 167 -2.63021
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.59446
NVL nuclear VCP-like -2.53597
RFC2 replication factor C (activator 1) 2, 40kDa -2.50362
PCNA proliferating cell nuclear antigen -2.42801
CD320 CD320 molecule -2.35412
CRELD2 cysteine-rich with EGF-like domains 2 -2.2577
LOC124907782 dual specificity protein phosphatase 22 -2.25492
TLCD3A TLC domain containing 3A -2.22332
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.1219
TXNDC9 thioredoxin domain containing 9 -2.02635