CRCGN013_HEPG2_24H:B03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

26 genes differentially expressed following the CRCGN013_HEPG2_24H:B03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 5.31672
BZW2 basic leucine zipper and W2 domains 2 4.87571
BACE2 beta-site APP-cleaving enzyme 2 4.6721
HLA-DRA major histocompatibility complex, class II, DR alpha 3.49163
MAP3K4 mitogen-activated protein kinase kinase kinase 4 3.2008
ANO1 anoctamin 1, calcium activated chloride channel 3.0966
ICAM1 intercellular adhesion molecule 1 2.97236
JADE2 jade family PHD finger 2 2.93113
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.78154
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.32307
CCNF cyclin F 2.11649
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.06406

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -6.42839
PCNA proliferating cell nuclear antigen -3.82808
CCNB2 cyclin B2 -3.66218
HMG20B high mobility group 20B -3.6402
EGF epidermal growth factor -3.60987
CDC25B cell division cycle 25B -3.52786
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.15394
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.54965
MRPS2 mitochondrial ribosomal protein S2 -2.45402
HLA-DMA major histocompatibility complex, class II, DM alpha -2.38305
ZNF134 zinc finger protein 134 -2.36612
PRPF4 pre-mRNA processing factor 4 -2.29704
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.21263
FAM13A family with sequence similarity 13, member A -2.093