CRCGN013_HEPG2_24H:B04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

72 genes differentially expressed following the CRCGN013_HEPG2_24H:B04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.63801
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.59185
GPER1 G protein-coupled estrogen receptor 1 5.08151
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.88364
CCNF cyclin F 4.35186
LOC122526780 uncharacterized LOC122526780 4.1233
TIAM1 T-cell lymphoma invasion and metastasis 1 3.96756
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.45875
GPATCH8 G patch domain containing 8 3.39487
SSBP2 single-stranded DNA binding protein 2 3.33092
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3.17877
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.1672
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.11949
CIAO3 cytosolic iron-sulfur assembly component 3 3.0172
COL4A1 collagen, type IV, alpha 1 3.00603
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.98587
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 2.94682
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.92307
SIRT3 sirtuin 3 2.88612
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.86453
PEX11A peroxisomal biogenesis factor 11 alpha 2.86251
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.70021
GRWD1 glutamate-rich WD repeat containing 1 2.65375
NOSIP nitric oxide synthase interacting protein 2.61486
ADAT1 adenosine deaminase, tRNA-specific 1 2.61188
PLS1 plastin 1 2.50187
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.48397
MINDY1 MINDY lysine 48 deubiquitinase 1 2.44697
DIPK1A divergent protein kinase domain 1A 2.44459
PADI3 peptidyl arginine deiminase, type III 2.32398
GARRE1 granule associated Rac and RHOG effector 1 2.32081
TPO thyroid peroxidase 2.20551
RRAGA Ras-related GTP binding A 2.19611
PLEK2 pleckstrin 2 2.19537
CNMD chondromodulin 2.17572
MARF1 meiosis regulator and mRNA stability factor 1 2.16453
SH3D19 SH3 domain containing 19 2.14076
SFTPB surfactant protein B 2.11825
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.10502
PON3 paraoxonase 3 2.10251
PLSCR3 phospholipid scramblase 3 2.09011
PRMT3 protein arginine methyltransferase 3 2.08967
TPD52L2 tumor protein D52-like 2 2.08451

decreased expression

Symbol Name Standardized Value
SCAND1 SCAN domain containing 1 -6.58613
PCNA proliferating cell nuclear antigen -6.17956
LDHD lactate dehydrogenase D -4.73895
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.62142
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -4.42585
ARID5B AT rich interactive domain 5B (MRF1-like) -4.08758
SMNDC1 survival motor neuron domain containing 1 -4.08704
CTSD cathepsin D -3.75636
TCTN1 tectonic family member 1 -3.64619
FGFR4 fibroblast growth factor receptor 4 -3.50077
EGF epidermal growth factor -3.48073
DERA deoxyribose-phosphate aldolase (putative) -3.44596
DUSP6 dual specificity phosphatase 6 -3.33645
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.11627
MRPS2 mitochondrial ribosomal protein S2 -2.98383
VDAC1 voltage-dependent anion channel 1 -2.87577
ITGB1BP1 integrin beta 1 binding protein 1 -2.83773
NRIP1 nuclear receptor interacting protein 1 -2.78523
YME1L1 YME1-like 1 ATPase -2.78415
RPS5 ribosomal protein S5 -2.6843
TM9SF3 transmembrane 9 superfamily member 3 -2.6673
CAB39 calcium binding protein 39 -2.28031
ZNF217 zinc finger protein 217 -2.20471
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.18673
L2HGDH L-2-hydroxyglutarate dehydrogenase -2.149
DYNLRB1 dynein, light chain, roadblock-type 1 -2.05841
SESN1 sestrin 1 -2.05455
CLDN10 claudin 10 -2.03396
NUP93 nucleoporin 93kDa -2.00922